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crygm2d6 crystallin, gamma M2d6 [ Danio rerio (zebrafish) ]

Gene ID: 415228, updated on 27-Mar-2024

Summary

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Official Symbol
crygm2d6provided by ZNC
Official Full Name
crystallin, gamma M2d6provided by ZNC
Primary source
ZFIN:ZDB-GENE-040625-145
See related
Ensembl:ENSDARG00000073874 AllianceGenome:ZFIN:ZDB-GENE-040625-145
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:86750
Summary
Predicted to be a structural constituent of eye lens. Predicted to be involved in lens development in camera-type eye and visual perception. Is expressed in lens. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: 9
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (22181416..22182396, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (22370547..22371527, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene crystallin, gamma M2d14 Neighboring gene crystallin, gamma M2d16 Neighboring gene crystallin, gamma M2d19 Neighboring gene crystallin, gamma M2d12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. AlphaA-crystallin expression prevents gamma-crystallin insolubility and cataract formation in the zebrafish cloche mutant lens. Goishi K, et al. Development, 2006 Jul. PMID 16728471
  2. Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages. Arcanjo C, et al. Aquat Toxicol, 2018 Jul. PMID 29751158
  3. Lens defects in Astyanax mexicanus Cavefish: evolution of crystallins and a role for alphaA-crystallin. Hinaux H, et al. Dev Neurobiol, 2015 May. PMID 25348293
  4. The zebrafish lens proteome during development and aging. Greiling TM, et al. Mol Vis, 2009 Nov 13. PMID 19936306, Free PMC Article
  5. Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Farnsworth DR, et al. Exp Eye Res, 2021 May. PMID 33705730, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables structural constituent of eye lens IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lens development in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in visual perception IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
crystallin, gamma M2d6
Names
crystallin gamma EM2-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002138.1 → NP_001002138.1  crystallin, gamma M2d6

    See identical proteins and their annotated locations for NP_001002138.1

    Status: PROVISIONAL

    Source sequence(s)
    BC071422
    UniProtKB/TrEMBL
    Q504G5, Q6IQI4
    Related
    ENSDARP00000092585.4, ENSDART00000101809.5
    Conserved Domains (2) summary
    smart00247
    Location:3 → 82
    XTALbg; Beta/gamma crystallins
    pfam00030
    Location:90 → 169
    Crystall; Beta/Gamma crystallin

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    22181416..22182396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394751.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    18..530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021472162.1 → XP_021327837.1  crystallin, gamma M2d6 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PA26
    Conserved Domains (1) summary
    smart00247
    Location:4 → 83
    XTALbg; Beta/gamma crystallins
Nucleotide Protein
Heading Accession and Version

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