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MBD1 methyl-CpG binding domain protein 1 [ Homo sapiens (human) ]

Gene ID: 4152, updated on 5-Oct-2014
Official Symbol
MBD1provided by HGNC
Official Full Name
methyl-CpG binding domain protein 1provided by HGNC
Primary source
HGNC:HGNC:6916
See related
Ensembl:ENSG00000141644; HPRD:01133; MIM:156535; Vega:OTTHUMG00000132669
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RFT; PCM1; CXXC3
Summary
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]
See MBD1 in Epigenomics, MapViewer
Location:
18q21
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 18 NC_000018.10 (50266882..50281774, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (47793252..47808144, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene myosin VB Neighboring gene microRNA 4320 Neighboring gene cilia and flagella associated protein 53 Neighboring gene CXXC finger protein 1 Neighboring gene spindle and kinetochore associated complex subunit 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
methyl-CpG binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
heterochromatin IEA
Inferred from Electronic Annotation
more info
 
nuclear matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
methyl-CpG-binding domain protein 1
Names
methyl-CpG-binding domain protein 1
CXXC-type zinc finger protein 3
protein containing methyl-CpG-binding domain 1
methyl-CpG binding domain protein 1 isoform PCM1
the regulator of fibroblast growth factor 2 (FGF-2) transcription

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029505.1 

    Range
    5001..19893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204136.1NP_001191065.1  methyl-CpG-binding domain protein 1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks the penultimate exon compared to variant 1. This results in a frame-shift, and a longer isoform (6) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AJ564845, AK225889, AK291519, AK302004, CD723822
    Consensus CDS
    CCDS59320.1
    UniProtKB/TrEMBL
    A8K654
    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000468785, OTTHUMP00000262941, ENST00000590208, OTTHUMT00000448756
    Conserved Domains (3) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam01690
    Location:493653
    PLRV_ORF5; Potato leaf roll virus readthrough protein
    pfam02008
    Location:331377
    zf-CXXC; CXXC zinc finger domain
  2. NM_001204137.1NP_001191066.1  methyl-CpG-binding domain protein 1 isoform 7

    See proteins identical to NP_001191066.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains an additional in-frame coding exon, and has a different 3' UTR compared to variant 1. This results in a longer isoform (7, also known as RFT-A) with an extra protein segment not found in isoform 1. This isoform has been shown to repress FGF-2 expression at the transcriptional level, and may be involved in FGF-2-dependent tumor progression (PMID:10187827).
    Source sequence(s)
    AK291519, AK295401, AK302004, BP384783
    Consensus CDS
    CCDS56073.1
    UniProtKB/TrEMBL
    A8K654
    UniProtKB/TrEMBL
    B4DI41
    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000405268, OTTHUMP00000262869, ENST00000457839, OTTHUMT00000448759
    Conserved Domains (2) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:356402
    zf-CXXC; CXXC zinc finger domain
  3. NM_001204138.1NP_001191067.1  methyl-CpG-binding domain protein 1 isoform 8

    See proteins identical to NP_001191067.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) is the same as variant 7, except uses an alternate acceptor splice site at one of the coding exons, resulting in an isoform (8, also known as RFT-Aprime) that is 1 aa shorter than isoform 7. Unlike isoform 7, this isoform fails to bind FGF-2 promoter and repress FGF-2 gene expression (PMID:10187827).
    Source sequence(s)
    AK291519, AK295401, AK302004, BP384783
    UniProtKB/TrEMBL
    A8K654
    UniProtKB/TrEMBL
    B4DI41
    UniProtKB/Swiss-Prot
    Q9UIS9
    Conserved Domains (2) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:356402
    zf-CXXC; CXXC zinc finger domain
  4. NM_001204139.1NP_001191068.1  methyl-CpG-binding domain protein 1 isoform 1

    See proteins identical to NP_001191068.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) contains an alternate 3' terminal non-coding exon, thus has a different 3' UTR compared to variant 1. Variants 1 and 14 encode the same isoform (1).
    Source sequence(s)
    AK291519, AK302004, BC047353
    Consensus CDS
    CCDS11943.1
    UniProtKB/TrEMBL
    A8K654
    UniProtKB/Swiss-Prot
    Q9UIS9
    Conserved Domains (2) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:331377
    zf-CXXC; CXXC zinc finger domain
  5. NM_001204140.1NP_001191069.1  methyl-CpG-binding domain protein 1 isoform 9

    See proteins identical to NP_001191069.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) is the same as variant 7, except lacks an in-frame coding exon, resulting in an isoform (9, also known as RFT-B) that is missing an internal protein segment compared to isoform 7. Unlike isoform 7, this isoform fails to bind FGF-2 promoter and repress FGF-2 gene expression (PMID:10187827).
    Source sequence(s)
    AK291519, AK295401, AK302004, BP384783
    UniProtKB/TrEMBL
    A8K654
    UniProtKB/TrEMBL
    B4DI41
    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000381508, OTTHUMP00000262943, ENST00000398495, OTTHUMT00000448882
    Conserved Domains (2) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  6. NM_001204141.1NP_001191070.1  methyl-CpG-binding domain protein 1 isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks 2 non-consecutive coding exons, and contains an alternate 3' terminal exon compared to variant 1. This results in a frame-shift in the 3' coding region, and a shorter isoform (10) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK225889, AK291519, AK302004, BC047353
    Consensus CDS
    CCDS59318.1
    UniProtKB/TrEMBL
    A8K654
    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000466092, OTTHUMP00000262939, ENST00000585672, OTTHUMT00000448751
    Conserved Domains (2) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:281327
    zf-CXXC; CXXC zinc finger domain
  7. NM_001204142.1NP_001191071.1  methyl-CpG-binding domain protein 1 isoform 11

    See proteins identical to NP_001191071.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks 3 non-consecutive coding exons, and uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift in the 3' coding region, and a shorter isoform (11) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF078831, AJ564845, AK291519, CD723822
    Consensus CDS
    CCDS56072.1
    UniProtKB/TrEMBL
    A8K654
    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000339546, OTTHUMP00000262865, ENST00000339998, OTTHUMT00000448755
    Conserved Domains (2) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:331377
    zf-CXXC; CXXC zinc finger domain
  8. NM_001204143.1NP_001191072.1  methyl-CpG-binding domain protein 1 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) lacks 3 non-consecutive coding exons, and uses an alternate donor splice site at the 5' non-coding exon and an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift in the 3' coding region, and a shorter isoform (12) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF078831, AJ564845, AK300759, CD723822
    Consensus CDS
    CCDS59319.1
    UniProtKB/TrEMBL
    B4DUR3
    UniProtKB/Swiss-Prot
    Q9UIS9
    Conserved Domains (2) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  9. NM_001204151.1NP_001191080.1  methyl-CpG-binding domain protein 1 isoform 13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) lacks 2 non-consecutive in-frame coding exons compared to variant 1. This results in a shorter isoform (13) missing two internal protein segments compared to isoform 1.
    Source sequence(s)
    AF078831, AK302004
    Consensus CDS
    CCDS56071.1
    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000465923, OTTHUMP00000262870, ENST00000591535, OTTHUMT00000448760
    Conserved Domains (2) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:308354
    zf-CXXC; CXXC zinc finger domain
  10. NM_002384.2NP_002375.1  methyl-CpG-binding domain protein 1 isoform 4

    See proteins identical to NP_002375.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks 2 in-frame non-consecutive coding exons compared to variant 1, resulting in a shorter isoform (4) missing two internal protein segments compared to isoform 1.
    Source sequence(s)
    AJ564845, AK225948, BC033242, DB458244, DC403953
    Consensus CDS
    CCDS11941.1
    UniProtKB/Swiss-Prot
    Q9UIS9
    Conserved Domains (2) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  11. NM_015844.2NP_056669.2  methyl-CpG-binding domain protein 1 isoform 3

    See proteins identical to NP_056669.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1, resulting in a shorter isoform (3) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AJ564845, AK225948, BC033242, DB458244, DC403953
    Consensus CDS
    CCDS11942.1
    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000285102, ENST00000347968
    Conserved Domains (2) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  12. NM_015845.3NP_056670.2  methyl-CpG-binding domain protein 1 isoform 2

    See proteins identical to NP_056670.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing 3 non-consecutive coding exons compared to variant 1, the last of which causes a frame-shift. This results in a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AJ564845, AK225889, AK225948, BC033242, DB458244, DC403953
    Consensus CDS
    CCDS32832.1
    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000269471, ENST00000269471
    Conserved Domains (2) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:308354
    zf-CXXC; CXXC zinc finger domain
  13. NM_015846.3NP_056671.2  methyl-CpG-binding domain protein 1 isoform 1

    See proteins identical to NP_056671.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1. Variants 1 and 14 encode the same isoform.
    Source sequence(s)
    AJ564845, AK225889, AK225948, BC033242, DB458244, DC403953
    Consensus CDS
    CCDS11943.1
    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000269468, ENST00000269468
    Conserved Domains (2) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:331377
    zf-CXXC; CXXC zinc finger domain
  14. NM_015847.3NP_056723.2  methyl-CpG-binding domain protein 1 isoform 5

    See proteins identical to NP_056723.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame coding exon compared to variant 1, resulting in a shorter isoform (5) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AJ564845, AK225889, AK225948, BC033242, DB458244, DC403953
    Consensus CDS
    CCDS11944.1
    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000269469, OTTHUMP00000163505, ENST00000353909, OTTHUMT00000255924
    Conserved Domains (2) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:282328
    zf-CXXC; CXXC zinc finger domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000018.10 

    Range
    50266882..50281774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258264.2XP_005258321.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:382428
    zf-CXXC; CXXC zinc finger domain
  2. XM_006722460.1XP_006722523.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:356402
    zf-CXXC; CXXC zinc finger domain
  3. XM_006722457.1XP_006722520.1  

    See proteins identical to XP_006722520.1

    UniProtKB/TrEMBL
    B4DI41
    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:382428
    zf-CXXC; CXXC zinc finger domain
  4. XM_006722473.1XP_006722536.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:357403
    zf-CXXC; CXXC zinc finger domain
  5. XM_006722468.1XP_006722531.1  

    Conserved Domains (2) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:331377
    zf-CXXC; CXXC zinc finger domain
  6. XM_006722462.1XP_006722525.1  

    Conserved Domains (2) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:331377
    zf-CXXC; CXXC zinc finger domain
  7. XM_006722456.1XP_006722519.1  

    Conserved Domains (2) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:356402
    zf-CXXC; CXXC zinc finger domain
  8. XM_006722470.1XP_006722533.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:194241
    zf-CXXC; CXXC zinc finger domain
  9. XM_006722466.1XP_006722529.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:194241
    zf-CXXC; CXXC zinc finger domain
  10. XM_006722464.1XP_006722527.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:357403
    zf-CXXC; CXXC zinc finger domain
  11. XM_006722474.1XP_006722537.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:357403
    zf-CXXC; CXXC zinc finger domain
  12. XM_006722455.1XP_006722518.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:357403
    zf-CXXC; CXXC zinc finger domain
  13. XM_005258262.1XP_005258319.1  

    Conserved Domains (3) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam01690
    Location:519679
    PLRV_ORF5; Potato leaf roll virus readthrough protein
    pfam02008
    Location:357403
    zf-CXXC; CXXC zinc finger domain
  14. XM_006722463.1XP_006722526.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:194241
    zf-CXXC; CXXC zinc finger domain
  15. XM_006722453.1XP_006722516.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:381427
    zf-CXXC; CXXC zinc finger domain
  16. XM_006722461.1XP_006722524.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:382428
    zf-CXXC; CXXC zinc finger domain
  17. XM_006722454.1XP_006722517.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:382428
    zf-CXXC; CXXC zinc finger domain
  18. XM_006722452.1XP_006722515.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:382428
    zf-CXXC; CXXC zinc finger domain
  19. XM_006722458.1XP_006722521.1  

    See proteins identical to XP_006722521.1

    UniProtKB/TrEMBL
    B4DI41
    Related
    ENSP00000468430, OTTHUMP00000262868, ENST00000585595, OTTHUMT00000448758
    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:382428
    zf-CXXC; CXXC zinc finger domain
  20. XM_006722459.1XP_006722522.1  

    See proteins identical to XP_006722522.1

    UniProtKB/TrEMBL
    B4DI41
    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:382428
    zf-CXXC; CXXC zinc finger domain
  21. XM_006722472.1XP_006722535.1  

    See proteins identical to XP_006722535.1

    UniProtKB/Swiss-Prot
    Q9UIS9
    Conserved Domains (2) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  22. XM_006722471.1XP_006722534.1  

    See proteins identical to XP_006722534.1

    UniProtKB/Swiss-Prot
    Q9UIS9
    Related
    ENSP00000381506, OTTHUMP00000163504, ENST00000398493, OTTHUMT00000255923
    Conserved Domains (2) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:168215
    zf-CXXC; CXXC zinc finger domain
  23. XM_005258271.1XP_005258328.1  

    See proteins identical to XP_005258328.1

    UniProtKB/Swiss-Prot
    Q9UIS9
    Conserved Domains (2) summary
    cd01396
    Location:575
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:331377
    zf-CXXC; CXXC zinc finger domain
  24. XM_005258274.1XP_005258331.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:194241
    zf-CXXC; CXXC zinc finger domain
  25. XM_005258272.1XP_005258329.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:194241
    zf-CXXC; CXXC zinc finger domain
  26. XM_006722475.1XP_006722538.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:357403
    zf-CXXC; CXXC zinc finger domain
  27. XM_005258268.1XP_005258325.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:357403
    zf-CXXC; CXXC zinc finger domain
  28. XM_006722469.1XP_006722532.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:194241
    zf-CXXC; CXXC zinc finger domain
  29. XM_006722467.1XP_006722530.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:194241
    zf-CXXC; CXXC zinc finger domain
  30. XM_006722465.1XP_006722528.1  

    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:382428
    zf-CXXC; CXXC zinc finger domain
  31. XM_005258265.1XP_005258322.1  

    See proteins identical to XP_005258322.1

    UniProtKB/TrEMBL
    B4DI41
    Conserved Domains (2) summary
    cd01396
    Location:31101
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam02008
    Location:382428
    zf-CXXC; CXXC zinc finger domain

Alternate HuRef

Genomic

  1. AC_000150.1 

    Range
    44647697..44662584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018929.2 

    Range
    47788841..47803733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)