PIM3 pim-3 oncogene [Homo sapiens] - Gene

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Summary

Official Symbol: PIM3provided by HGNC
Official Full Name: pim-3 oncogeneprovided by HGNC
Primary source: HGNC:19310
Locus tag: CITF22-49E9.1
See related: Ensembl:ENSG00000198355; HPRD:15137; MIM:610580; Vega:OTTHUMG00000150290
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: pim-3
Summary: PIM3 belongs to a family of protooncogenes that encode serine/threonine protein kinases (Mikkers et al., 2004 [PubMed 15199164]).[supplied by OMIM, Mar 2008]

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Genomic context

Location :: 22q13

Sequence :: Chromosome: 22; NC_000022.10 (50354143..50357720)

See PIM3 in Epigenomics, MapViewer

Chromosome 22 - NC_000022.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pim protein kinase-3 is regulated by TNF-alpha and promotes endothelial cell sprouting.
Title: Pim protein kinase-3 is regulated by TNF-α and promotes endothelial cell sprouting.
Pim3 cooperates with other Pim kinases in supporting viability of Myc-induced B-cell lymphomas.
Title: The direct Myc target Pim3 cooperates with other Pim kinases in supporting viability of Myc-induced B-cell lymphomas.
Ginsenoside Rg3 decreased both Pim-3 and pBad expressions in a dose-dependent manner in PANC-1 cells.
Title: [Effect of ginsenoside Rg3 on Pim-3 and Bad proteins in human pancreatic cancer cell line PANC-1].
A cell-based test system useful for rapid and inexpensive pre-screening of compounds capable of preventing Pim-mediated phosphorylation is discussed.
Title: Fighting tumor cell survival: advances in the design and evaluation of Pim inhibitors.
Pim-3 has an important role in modulating c-Myc and PGC-1alpha protein levels and cell growth
Title: The Pim protein kinases regulate energy metabolism and cell growth.
Pim-3 alone cannot cause, but can accelerate HCC development.
Title: Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver.
expression of Pim-1 & Pim-3 is induced in response reactivation in KSHV-infected cells; they are required for KSHV reactivation under these conditions; data indicate Pim-1 & Pim-3 contribute to viral reactivation by phosphorylating the KSHV LANA
Title: KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA.
Ets-1 can induce aberrant Pim-3 expression and subsequently prevent apoptosis in human pancreatic cancer cells.
Title: Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells.
Pim kinases promote cell cycle progression and tumorigenesis by down-regulating p27(Kip1) expression at both transcriptional and posttranslational levels.
Title: Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels.
Aberrnntly expressed Pim-3 can cause autonomous cell proliferation or prevent apoptosis in hepatoma cell lines.
Title: Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
Q86V86	Q92934	BAD		HPRD	PubMed
BioGRID:136104	BioGRID:113164	UBC		BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
cell cycle	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of insulin secretion involved in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: serine/threonine-protein kinase pim-3

Names: serine/threonine-protein kinase pim-3; serine/threonine kinase Pim-3

NP_001001852.2

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001852.3 → NP_001001852.2 serine/threonine-protein kinase pim-3

Status: VALIDATED

Source sequence(s)

AB114795, CR536608, CT000425, DB482257

Consensus CDS

CCDS33678.1

UniProtKB/Swiss-Prot

Q86V86

Related

ENSP00000353824, OTTHUMP00000196970, ENST00000360612, OTTHUMT00000317406

Conserved Domains (2) summary

cd00180
Location:46 – 291
Blast Score: 403

PKc; Catalytic domain of Protein Kinases

pfam00069
Location:40 – 293
Blast Score: 595

Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000022.10 Reference GRCh37.p5 Primary Assembly

Range

50354143..50357720

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000154.1 Alternate HuRef

Range

33300609..33304139

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	BX539320.10	CAO03581.1
genomic	CH471138.1	EAW73485.1
genomic	CR536608.3	CAO03523.1
mRNA	AB114795.1	BAD42438.1
mRNA	AK292005.1	BAF84694.1
mRNA	BC017083.2	None
mRNA	BC052239.1	None
mRNA	BC064477.1	AAH64477.1
mRNA	BC141855.1	AAI41856.1
mRNA	CT000425.1	None
mRNA	DB482257.1	None
other-genetic	BC140030.1	AAI40031.1