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    MATK megakaryocyte-associated tyrosine kinase [ Homo sapiens ]

    Gene ID: 4145, updated on 11-May-2012
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    Summary

    Official Symbol
    MATKprovided by HGNC
    Official Full Name
    megakaryocyte-associated tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:6906
    See related
    Ensembl:ENSG00000007264; HPRD:02496; MIM:600038
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CHK; CTK; HYL; Lsk; HYLTK; HHYLTK; MGC1708; MGC2101; DKFZp434N1212
    Summary
    The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    19p13.3
    Sequence :
    Chromosome: 19; NC_000019.9 (3777967..3801810, complement)
    See MATK in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene retina and anterior neural fold homeobox 2 Neighboring gene zinc finger RNA binding protein 2 Neighboring gene ferritin, light polypeptide pseudogene 5

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    2. IGF-I stimulates cooperative interaction between the IGF-I receptor and CSK homologous kinase that regulates SHPS-1 phosphorylation in vascular smooth muscle cells. Radhakrishnan Y, et al. Mol Endocrinol, 2011 Sep. PMID 21799000.
    3. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. Oshikawa M, et al. Invest Ophthalmol Vis Sci, 2011 Aug. PMID 21697133.
    4. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. Kahle JJ, et al. Hum Mol Genet, 2011 Feb 1. PMID 21078624.
    5. Csk homologous kinase inhibits CXCL12-CXCR4 signaling in neuroblastoma. Zagozdzon R, et al. Int J Oncol, 2008 Mar. PMID 18292939.

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. After IGF-I stimulation, CTK is recruited to IGF-IR and its recruitment facilitates CTK's subsequent association with phospho-SHPS-1.
      Title: IGF-I stimulates cooperative interaction between the IGF-I receptor and CSK homologous kinase that regulates SHPS-1 phosphorylation in vascular smooth muscle cells.
    2. CHK is capable of inhibiting the CXCL12-CXCR4 pathway in neuroblastoma.
      Title: Csk homologous kinase inhibits CXCL12-CXCR4 signaling in neuroblastoma.
    3. These results reveal a potentially important role for CHK in Src activation and tumorigenicity in colon cancer cells.
      Title: Decreased CHK protein levels are associated with Src activation in colon cancer cells.
    4. Progesterone increases MATK in mast cells and reducs cell proliferation.
      Title: Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation.
    5. Overexpression of the Csk homologous kinase facilitates phosphorylation of akt/protein kinase b in breast neoplasms
      Title: Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells.
    6. CHK Leu223 stabilizes the movement of the alphaC-helix of the protein tyrosine kinase
      Title: Conserved hydrophobicity in the SH2-kinase linker is required for catalytic activity of Csk and CHK.
    7. Findings indicate that the importance of the N-terminal domain to Chk-induced tyrosine phosphorylation in the nucleus, and implicate that nuclear tyrosine-phosphorylated proteins may contribute to inhibition of cell proliferation.
      Title: Involvement of the N-terminal unique domain of Chk tyrosine kinase in Chk-induced tyrosine phosphorylation in the nucleus.
    8. Nuclear multi-lobulation in late S phase, which is dependent on polymerization and depolymerization of microtubules, may be involved in nuclear Chk-induced inhibition of proliferation.
      Title: Multi-lobulation of the nucleus in prolonged S phase by nuclear expression of Chk tyrosine kinase.
    9. ERBB2 binds to the SH2 domain of CHK and inhibits cell growth in human breast tumor cell lines
      Title: Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer.
    10. This study describes for the first time the Src-independent actions of CHK and provides novel insights into CHK function in neural cells.
      Title: Csk homologous kinase (CHK), unlike Csk, enhances MAPK activation via Ras-mediated signaling in a Src-independent manner.
    Submit: New GeneRIF Correction See all (13)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P42679 P16671 CD36    HPRD  PubMed  
    P42679 P04626 ERBB2    HPRD  PubMed  
    P42679 Q01844 EWSR1    HPRD  PubMed  
    P42679 P10721 KIT    HPRD  PubMed  
    P42679 P07948 LYN    HPRD  PubMed  
    P42679 P04629 NTRK1    HPRD  PubMed  
    P42679 Q14289 PTK2B    HPRD  PubMed  
    P42679 P49023 PXN    HPRD  PubMed  
    P42679 P12931 SRC    HPRD  PubMed  
    BioGRID:110315 BioGRID:107227 CACNA1A    BioGRID  PubMed Two-hybrid 
    BioGRID:110315 BioGRID:107386 CD36    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110315 BioGRID:108431 EWSR1    BioGRID  PubMed Two-hybrid 
    BioGRID:110315 BioGRID:110015 KIT    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110315 BioGRID:110969 NTRK1    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:110315 BioGRID:111787 PXN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110315 BioGRID:112592 SRC    BioGRID  PubMed Biochemical Activity 
    BioGRID:110315 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
    • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
      Neurotrophic factor-mediated Trk receptor signaling
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
      Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
    • Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem
      Signaling events mediated by Stem cell factor receptor (c-Kit)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mesoderm development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    megakaryocyte-associated tyrosine-protein kinase
    Names
    megakaryocyte-associated tyrosine-protein kinase
    protein kinase HYL
    HYL tyrosine kinase
    tyrosine kinase MATK
    CSK homologous kinase
    Csk-homologous kinase
    tyrosylprotein kinase
    hydroxyaryl-protein kinase
    tyrosine-protein kinase CTK
    Csk-type protein tyrosine kinase
    leukocyte carboxyl-terminal src kinase related
    hematopoietic consensus tyrosine-lacking kinase
    NP_002369.2
    NP_647611.1
    NP_647612.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002378.3 → NP_002369.2  megakaryocyte-associated tyrosine-protein kinase isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate region at the 5' end of the coding region and lacks two exons in the coding region, as compared to variant 1. The encoded isoform b has a slightly longer and unique N-terminus compared to isoform a.
      Source sequence(s)
      AK055395, BC000114, DA592994, X77278
      Consensus CDS
      CCDS12113.1
      UniProtKB/Swiss-Prot
      P42679
      Related
      ENSP00000378485, ENST00000395045
      Conserved Domains (4) summary
      cd05083
      Location:229 – 482
      Blast Score: 1328
      PTKc_Chk; Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase
      smart00221
      Location:236 – 479
      Blast Score: 926
      STYKc; Protein kinase; unclassified specificity.
      cd09937
      Location:119 – 216
      Blast Score: 499
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cl15350
      Location:50 – 94
      Blast Score: 104
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...

    2. NM_139354.2 → NP_647611.1  megakaryocyte-associated tyrosine-protein kinase isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the coding region, and utilizes a downstream in-frame start codon, compared to variant 1. Isoform c has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AL137754, BG396388, BQ109562, X77278
      Consensus CDS
      CCDS42468.1
      UniProtKB/Swiss-Prot
      P42679
      UniProtKB/TrEMBL
      Q9NST8
      Related
      ENSP00000378481, ENST00000395040
      Conserved Domains (4) summary
      cd05083
      Location:187 – 440
      Blast Score: 1329
      PTKc_Chk; Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase
      smart00221
      Location:194 – 437
      Blast Score: 926
      STYKc; Protein kinase; unclassified specificity.
      cd09937
      Location:77 – 174
      Blast Score: 498
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cl15350
      Location:8 – 52
      Blast Score: 104
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...

    3. NM_139355.2 → NP_647612.1  megakaryocyte-associated tyrosine-protein kinase isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the predominant isoform a.
      Source sequence(s)
      BC000114, BG396388, BM925586, X77278
      Consensus CDS
      CCDS12114.1
      UniProtKB/TrEMBL
      F1T0G6
      UniProtKB/Swiss-Prot
      P42679
      Related
      ENSP00000308734, ENST00000310132
      Conserved Domains (4) summary
      cd05083
      Location:228 – 481
      Blast Score: 1329
      PTKc_Chk; Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase
      smart00221
      Location:235 – 478
      Blast Score: 927
      STYKc; Protein kinase; unclassified specificity.
      cd09937
      Location:118 – 215
      Blast Score: 500
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cl15350
      Location:49 – 93
      Blast Score: 104
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      3777967..3801810, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      3542732..3566615, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC005777.1 AAC62843.1
    genomic CH471139.2 EAW69284.1
      EAW69285.1
      EAW69286.1
      EAW69287.1
    genomic S75164.1 AAC60645.1
    genomic S75168.1 AAC60645.1
    mRNA AB593100.1 BAJ84040.1
    mRNA AK055395.1 BAG51511.1
    mRNA AK225834.1 None
    mRNA AK315646.1 BAG38013.1
    mRNA AL137754.1 CAB70906.2
    mRNA BC000114.1 AAH00114.1
    mRNA BC003109.1 AAH03109.1
    mRNA BG396388.1 None
    mRNA BM925586.1 None
    mRNA BQ109562.1 None
    mRNA DA592994.1 None
    mRNA L18974.1 AAA16703.1
    mRNA S71669.1 AAB30995.1
    mRNA X77278.1 CAA54493.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42679.1 GenPept UniProtKB/Swiss-Prot:P42679
    Q16176 GenPept UniProtKB/TrEMBL:Q16176
    Q9NST8 GenPept UniProtKB/TrEMBL:Q9NST8
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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