MAT2A methionine adenosyltransferase II, alpha [Homo sapiens] - Gene

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Summary

Official Symbol: MAT2Aprovided by HGNC
Official Full Name: methionine adenosyltransferase II, alphaprovided by HGNC
Primary source: HGNC:6904
See related: Ensembl:ENSG00000168906; HPRD:03275; MIM:601468; Vega:OTTHUMG00000130174
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MATA2; MATII; SAMS2
Summary: The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]

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Genomic context

Location :: 2p11.2

Sequence :: Chromosome: 2; NC_000002.11 (85766101..85772403)

See MAT2A in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

hypoxia-induced MAT2A expression is HIF-1alpha dependent
Title: Hypoxia induces genomic DNA demethylation through the activation of HIF-1α and transcriptional upregulation of MAT2A in hepatoma cells.
Insulin-like growth factor 1 (IGF1) activates methionine adenosyltransferase 2A MAT2A) transcription by both known and novel pathways in colon cancer cells.
Title: Insulin-like growth factor 1 activates methionine adenosyltransferase 2A transcription by multiple pathways in human colon cancer cells.
X protein of hepatitis B virus inhibits apoptosis in hepatoma cells through enhancing the methionine adenosyltransferase 2A gene expression and reducing S-adenosylmethionine production
Title: The X protein of hepatitis B virus inhibits apoptosis in hepatoma cells through enhancing the methionine adenosyltransferase 2A gene expression and reducing S-adenosylmethionine production.
Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein
Title: Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
This work was carried out to examine the role of MAT II activity and S-adenosylmethionine biosynthesis in the survival of leukemic T cells.
Title: Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk.
Observational study of gene-disease association. (HuGE Navigator)
Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Lower expression of both MAT2A and MAT2beta and interfere with leptin signaling in liver cancer cells.
Title: Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta.
regulation of expression in hepatocarcinoma cells by L-methionine availability
Title: L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine.

Submit: New GeneRIF Correction See all (13)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P31153	Methionine adenosyletransferase II, beta	MAT2B	HPRD	PubMed
BioGRID:110314	BioGRID:114593	HGS	BioGRID	PubMed	Reconstituted Complex
BioGRID:110314	BioGRID:118166	MAT2B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110314	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
methionine adenosyltransferase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
S-adenosylmethionine biosynthetic process	IEA Inferred from Electronic Annotation more info
cellular nitrogen compound metabolic process	TAS Traceable Author Statement more info
circadian rhythm	IEA Inferred from Electronic Annotation more info
methylation	TAS Traceable Author Statement more info
response to cAMP	IEA Inferred from Electronic Annotation more info
response to drug	IEA Inferred from Electronic Annotation more info
response to hormone stimulus	IEA Inferred from Electronic Annotation more info
response to light stimulus	IEA Inferred from Electronic Annotation more info
small molecule metabolic process	TAS Traceable Author Statement more info
sulfur amino acid metabolic process	TAS Traceable Author Statement more info
xenobiotic metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytosol	TAS Traceable Author Statement more info

General protein information

Preferred Names: S-adenosylmethionine synthase isoform type-2

Names: S-adenosylmethionine synthase isoform type-2; MAT 2; MAT-II; adoMet synthase 2; adoMet synthetase 2; methionine adenosyltransferase 2

NP_005902.1

EC 2.5.1.6

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029183.1 RefSeqGene

Range

5001..11303

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_005911.5 → NP_005902.1 S-adenosylmethionine synthase isoform type-2

Status: REVIEWED

Source sequence(s)

AC016753, BC001686, DC322518

Consensus CDS

CCDS1977.1

UniProtKB/Swiss-Prot

P31153

Related

ENSP00000303147, OTTHUMP00000160677, ENST00000306434, OTTHUMT00000252491

Conserved Domains (4) summary

pfam02773
Location:252 – 388
Blast Score: 654

S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain

PTZ00104
Location:16 – 395
Blast Score: 1773

PTZ00104; S-adenosylmethionine synthase; Provisional

pfam00438
Location:16 – 115
Blast Score: 508

S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain

pfam02772
Location:128 – 250
Blast Score: 580

S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

85766101..85772403

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

85662610..85669745

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC016753.9	AAY24339.1
genomic	CH471053.2	EAW99511.1
		EAW99512.1
		EAW99513.1
		EAW99514.1
mRNA	AK291126.1	BAF83815.1
mRNA	AK293841.1	BAG57239.1
mRNA	AK297758.1	BAG60107.1
mRNA	AK297797.1	BAG60136.1
mRNA	AK303877.1	BAG64814.1
mRNA	AK308591.1	None
mRNA	AK308758.1	None
mRNA	AK309338.1	None
mRNA	AK316411.1	BAH14782.1
mRNA	BC001686.2	AAH01686.1
mRNA	BC001854.2	AAH01854.1
mRNA	BI549760.1	None
mRNA	DC322518.1	None
mRNA	DQ083239.1	AAY85355.1
mRNA	X68836.1	CAA48726.1
other-genetic	JF432119.1	ADZ15336.1