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    ClC-a Chloride channel-a [ Drosophila melanogaster ]

    Gene ID: 41428, updated on 10-May-2012
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    Summary

    Official Symbol
    ClC-aprovided by Flybase
    Official Full Name
    Chloride channel-aprovided by Flybase
    Primary source
    FLYBASE:FBgn0051116
    Locus tag
    Dmel_CG31116
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14726; CG31116; CG6942; DmClC-2; DmClC-a; DmClCa; Dmel\CG31116; FBgn0037951
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    Genomic context

    Location :
    86F8-86F8
    Sequence :
    Chromosome: 3R; NT_033777.2 (7622966..7638929, complement)
    See ClC-a in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene CG17360 gene product from transcript CG17360-RA Neighboring gene Histamine-gated chloride channel subunit 1 Neighboring gene SET domain binding factor Neighboring gene glorund Neighboring gene CG6950 gene product from transcript CG6950-RC Neighboring gene Cytochrome c oxidase subunit Va

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Properties and possible function of a hyperpolarisation-activated chloride current in Drosophila. Rose U, et al. J Exp Biol, 2007 Jul. PMID 17601953.
    2. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.
    3. The Release 5.1 annotation of Drosophila melanogaster heterochromatin. Smith CD, et al. Science, 2007 Jun 15. PMID 17569856.
    4. RNA editing in Drosophila melanogaster: New targets and functional consequences. Stapleton M, et al. RNA, 2006 Nov. PMID 17018572.
    5. Evolution of exon-intron structure and alternative splicing in fruit flies and malarial mosquito genomes. Malko DB, et al. Genome Res, 2006 Apr. PMID 16520458.

    See all (16) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:66550 BioGRID:61365 Cul-2    BioGRID  PubMed Two-hybrid 
    BioGRID:66550 BioGRID:68286 Doa    BioGRID  PubMed Two-hybrid 
    BioGRID:66550 BioGRID:68794 Pak    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the ClC-a gene: The ClC-a gene is conserved in human, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, and C.elegans.

    mobile_element

    • Loc: c7633505-7633305 mobile_element_type = transposon:INE-1{}2915

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    chloride channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    voltage-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    chloride transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    insoluble fraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    CG31116 gene product from transcript CG31116-RG
    Names
    CG31116-PA
    CG31116-PC
    CG31116-PD
    CG31116-PF
    CG31116-PG
    CG31116-PH
    ClC-a-PA
    ClC-a-PC
    ClC-a-PD
    ClC-a-PF
    ClC-a-PG
    ClC-a-PH
    chloride channel-a
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      7622966..7638929, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104281.2 → NP_001097751.2  chloride channel-a, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGH7
      Related
      FBpp0289849, FBtr0300622
      Conserved Domains (3) summary
      cd04591
      Location:844 – 921
      Blast Score: 186
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      cd03683
      Location:123 – 585
      Blast Score: 1404
      ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
      pfam00654
      Location:179 – 567
      Blast Score: 477
      Voltage_CLC; Voltage gated chloride channel

    2. NM_001170121.1 → NP_001163592.1  chloride channel-a, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGH7
      Related
      FBpp0290245, FBtr0301023
      Conserved Domains (3) summary
      cd04591
      Location:952 – 1048
      Blast Score: 189
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      cd03683
      Location:123 – 585
      Blast Score: 1428
      ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
      pfam00654
      Location:179 – 567
      Blast Score: 494
      Voltage_CLC; Voltage gated chloride channel

    3. NM_001104282.2 → NP_001097752.1  chloride channel-a, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1UUP0
      UniProtKB/Swiss-Prot
      Q9VGH7
      Related
      FBpp0112303, FBtr0113391
      Conserved Domains (4) summary
      cd04591
      Location:892 – 969
      Blast Score: 187
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      cd03683
      Location:171 – 633
      Blast Score: 1414
      ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
      pfam00654
      Location:227 – 615
      Blast Score: 487
      Voltage_CLC; Voltage gated chloride channel
      pfam13666
      Location:19 – 90
      Blast Score: 185
      DUF4151; Domain of unknown function (DUF4151)

    4. NM_176462.1 → NP_788639.1  chloride channel-a, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGH7
      Related
      FBpp0082002, FBtr0082528
      Conserved Domains (4) summary
      cd04591
      Location:1000 – 1096
      Blast Score: 190
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      cd03683
      Location:171 – 633
      Blast Score: 1436
      ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
      pfam00654
      Location:227 – 615
      Blast Score: 502
      Voltage_CLC; Voltage gated chloride channel
      pfam13666
      Location:19 – 90
      Blast Score: 181
      DUF4151; Domain of unknown function (DUF4151)

    5. NM_169431.2 → NP_731634.2  chloride channel-a, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGH7
      Related
      FBpp0082001, FBtr0082527
      Conserved Domains (3) summary
      cd04591
      Location:875 – 952
      Blast Score: 188
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      cd03683
      Location:154 – 616
      Blast Score: 1430
      ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
      pfam00654
      Location:210 – 598
      Blast Score: 498
      Voltage_CLC; Voltage gated chloride channel

    6. NM_169432.2 → NP_731635.2  chloride channel-a, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGH7
      Related
      FBpp0082000, FBtr0082526
      Conserved Domains (3) summary
      cd04591
      Location:983 – 1079
      Blast Score: 191
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      cd03683
      Location:154 – 616
      Blast Score: 1451
      ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
      pfam00654
      Location:210 – 598
      Blast Score: 511
      Voltage_CLC; Voltage gated chloride channel
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014297.2 ABW08644.2
    mRNA BT030454.1 ABP87896.1
    genomic AE014297.2 ACZ94889.1
    mRNA BT133125.1 AEY64293.1
    genomic AE014297.2 ABW08645.1
    genomic AE014297.2 AAF54702.3
    genomic AE014297.2 AAN13532.2
    genomic AE014297.2 AAF54701.3
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGH7.3 GenPept
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    Additional Links

    Gene LinkOut

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