MARS methionyl-tRNA synthetase [Homo sapiens] - Gene

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Summary

Official Symbol: MARSprovided by HGNC
Official Full Name: methionyl-tRNA synthetaseprovided by HGNC
Primary source: HGNC:6898
See related: Ensembl:ENSG00000166986; HPRD:08864; MIM:156560; Vega:OTTHUMG00000169996
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MRS; METRS; MTRNS; FLJ35667
Summary: This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011]

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Genomic context

Location :: 12q13

Sequence :: Chromosome: 12; NC_000012.11 (57881736..57910438)

See MARS in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3)/p18 is released from aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3) by UV irradiation-induced stress.
Title: Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of aminoacyl-tRNA synthetase-interacting multifunctional protein-3.
The last 15 residues of the previously defined N-terminal extension of hcMetRS are part of the catalytic domain, whereas the first 252 residues constitute the N-terminal extended domain.
Title: Two non-redundant fragments in the N-terminal peptide of human cytosolic methionyl-tRNA synthetase were indispensable for the multi-synthetase complex incorporation and enzyme activity.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P56192	Q9BUJ2	HNRNPUL1	HPRD	PubMed
P56192	O60675	MAFK	HPRD	PubMed
P56192	Q16539	MAPK14	HPRD	PubMed
P56192	P49593	PPM1F	HPRD	PubMed
BioGRID:110311	BioGRID:120578	BRF2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110311	BioGRID:107459	CDK9	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110311	BioGRID:115978	GIPC1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110311	BioGRID:115331	HDAC5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110311	BioGRID:109824	ILK	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110311	BioGRID:110333	MCC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110311	BioGRID:110694	MYC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110311	BioGRID:111551	PRKAB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110311	BioGRID:112146	RPS27	BioGRID	PubMed	Two-hybrid
BioGRID:110311	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110311	BioGRID:112992	TNNT1	BioGRID	PubMed	Two-hybrid
BioGRID:110311	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
ligase activity	IEA Inferred from Electronic Annotation more info
methionine-tRNA ligase activity	TAS Traceable Author Statement more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
gene expression	TAS Traceable Author Statement more info
methionyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
tRNA aminoacylation for protein translation	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	TAS Traceable Author Statement more info
mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: methionine--tRNA ligase, cytoplasmic

Names: methionine--tRNA ligase, cytoplasmic; cytosolic methionyl-tRNA synthetase; methionine tRNA ligase 1, cytoplasmic

NP_004981.2

EC 6.1.1.10

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004990.3 → NP_004981.2 methionine--tRNA ligase, cytoplasmic

Status: REVIEWED

Source sequence(s)

BC011849, D84224, DA489707

Consensus CDS

CCDS8942.1

UniProtKB/Swiss-Prot

P56192

Related

ENSP00000262027, OTTHUMP00000242693, ENST00000262027, OTTHUMT00000407014

Conserved Domains (5) summary

cd00939
Location:845 – 885
Blast Score: 155

MetRS_RNA; MetRS_RNA binding domain. This short RNA-binding domain is found at the C-terminus of MetRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is repeated in Drosophila MetRS. This domain consists of a helix-turn-helix structure, which is ...

cd07957
Location:653 – 771
Blast Score: 349

Anticodon_Ia_Met; Anticodon-binding domain of methionyl tRNA synthetases

cd00814
Location:265 – 633
Blast Score: 1264

MetRS_core; catalytic core domain of methioninyl-tRNA synthetases

PRK12268
Location:264 – 819
Blast Score: 1742

PRK12268; methionyl-tRNA synthetase; Reviewed

cd10307
Location:77 – 179
Blast Score: 386

GST_C_MetRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Methionyl-tRNA synthetase from higher eukaryotes

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p5 Primary Assembly

Range

57881736..57910438

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

54919857..54948436

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC022506.38 (91436..120018)	None
genomic	CH471054.1	EAW97019.1
		EAW97020.1
genomic	HH961788.1	CBX51367.1
mRNA	AK092986.1	BAC04011.1
mRNA	AK122956.1	BAG53819.1
mRNA	AK222767.1	BAD96487.1
mRNA	AK290857.1	BAF83546.1
mRNA	AK293945.1	BAG57322.1
mRNA	AK303349.1	BAG64411.1
mRNA	BC002384.2	AAH02384.1
mRNA	BC006328.2	AAH06328.1
mRNA	BC011639.2	AAH11639.1
mRNA	BC011849.2	AAH11849.1
mRNA	BC015011.1	AAH15011.1
mRNA	BC065187.1	None
mRNA	BT007338.1	AAP36002.1
mRNA	D84224.1	BAA95668.1
mRNA	DA489707.1	None
mRNA	X94754.1	CAA64381.1
mRNA	Z49216.1	CAA89153.1