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    MARK3 MAP/microtubule affinity-regulating kinase 3 [ Homo sapiens ]

    Gene ID: 4140, updated on 19-May-2012
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    Summary

    Official Symbol
    MARK3provided by HGNC
    Official Full Name
    MAP/microtubule affinity-regulating kinase 3provided by HGNC
    Primary source
    HGNC:6897
    See related
    Ensembl:ENSG00000075413; HPRD:04058; MIM:602678; Vega:OTTHUMG00000171789
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KP78; CTAK1; PAR1A; Par-1a
    Summary
    The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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    Genomic context

    Location :
    14q32.3
    Sequence :
    Chromosome: 14; NC_000014.8 (103851701..103970168)
    See MARK3 in Epigenomics, MapViewer

    Chromosome 14 - NC_000014.8Genomic Context describing neighboring genes Neighboring gene high mobility group box 3 pseudogene 26 Neighboring gene ribosomal protein SA pseudogene 5 Neighboring gene ribosomal protein L10a pseudogene 1 Neighboring gene creatine kinase, brain Neighboring gene tRNA methyltransferase 61 homolog A (S. cerevisiae)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    3. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. Giannone RJ, et al. PLoS One, 2010 Aug 25. PMID 20811636.
    4. Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women. Liu JM, et al. J Clin Endocrinol Metab, 2010 Sep. PMID 20554715.
    5. OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts. Paternoster L, et al. J Clin Endocrinol Metab, 2010 Aug. PMID 20534768.

    See all (42) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women.
    2. Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
      Title: OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts.
    3. interaction between Mitf and C-TAK1 was demonstrated.
      Title: C-TAK1 interacts with microphthalmia-associated transcription factor, Mitf, but not the related family member Tfe3.
    4. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: New sequence variants associated with bone mineral density.
    5. identify a molecular mechanism through which the hMARK3 UBA domain has evolved to bind the kinase domain
      Title: Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain.
    6. occurrence of an unusual TG 3' splice site in intron 3
      Title: Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.
    7. Data show that the protein kinase Cdc25 C-associated kinase 1 (C-TAK1) is a binding partner and a substrate of Pim-1, and suggest a role for Pim-1 as a positive regulator at the G(2)/M transition of the cell cycle.
      Title: The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint.
    8. identify sequence motifs required for stable C-TAK1 association and substrate phosphorylation
      Title: Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate.
    9. 14-3-3 binding to MARK3 is dependent on phosphorylation.
      Title: Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation.
    10. results show that LKB1 can direct the phosphorylation of the serine-threonine kinase PAR1A
      Title: Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1.
    Submit: New GeneRIF Correction See all (12)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P27448 Q92527 ANKRD7    HPRD  PubMed  
    P27448 Q8WXK3 ASB13    HPRD  PubMed  
    P27448 P27449 ATP6V0C    HPRD  PubMed  
    P27448 P30307 CDC25C    HPRD  PubMed  
    P27448 P05060 CHGB    HPRD  PubMed  
    P27448 O95639 CPSF4    HPRD  PubMed  
    P27448 P63167 DYNLL1    HPRD  PubMed  
    P27448 Q9NPI8 FANCF    HPRD  PubMed  
    P27448 Q8IVT5 KSR1    HPRD  PubMed  
    P27448 Q9H8H0 NOL11    HPRD  PubMed  
    P27448 Q99959 PKP2    HPRD  PubMed  
    P27448 O75439 PMPCB    HPRD  PubMed  
    P27448 Patatin like phospholipase domain containing 2 PNPLA2    HPRD  PubMed  
    P27448 Q04759 PRKCQ    HPRD  PubMed  
    P27448 Q96ER3 SAAL1    HPRD  PubMed  
    P27448 P31947 SFN    HPRD  PubMed  
    P27448 Q15560 TCEA2    HPRD  PubMed  
    P27448 P02766 TTR    HPRD  PubMed  
    P27448 Q9H270 VPS11    HPRD  PubMed  
    P27448 P61981 YWHAG    HPRD  PubMed  
    P27448 P63104 YWHAZ    HPRD  PubMed  
    BioGRID:110310 BioGRID:107010 ATP6V0C    BioGRID  PubMed Two-hybrid 
    BioGRID:110310 BioGRID:107539 CHGB    BioGRID  PubMed Two-hybrid 
    BioGRID:110310 BioGRID:115106 HDAC4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110310 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110310 BioGRID:119613 HDAC7    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:110310 BioGRID:108326 MARK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110310 BioGRID:110432 MITF    BioGRID  PubMed Two-hybrid 
    BioGRID:110310 BioGRID:114889 PMPCB    BioGRID  PubMed Two-hybrid 
    BioGRID:110310 BioGRID:121370 PNPLA2    BioGRID  PubMed Two-hybrid 
    BioGRID:110310 BioGRID:111549 PRKAA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110310 BioGRID:111858 RASGRF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110310 BioGRID:125228 SAAL1    BioGRID  PubMed Two-hybrid 
    BioGRID:110310 BioGRID:109072 SFN    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:110310 BioGRID:112734 TADA2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110310 BioGRID:112781 TCEA2    BioGRID  PubMed Two-hybrid 
    BioGRID:110310 BioGRID:112873 TERF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110310 BioGRID:113127 TTR    BioGRID  PubMed Two-hybrid 
    BioGRID:110310 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:110310 BioGRID:117950 USP21    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110310 BioGRID:120930 VPS11    BioGRID  PubMed Two-hybrid 
    BioGRID:110310 BioGRID:113361 YWHAB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110310 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110310 BioGRID:113365 YWHAH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110310 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110310 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
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    General protein information

    Preferred Names
    MAP/microtubule affinity-regulating kinase 3
    Names
    MAP/microtubule affinity-regulating kinase 3
    EMK-2
    C-TAK1
    ELKL motif kinase 2
    protein kinase STK10
    ser/Thr protein kinase PAR-1
    cdc25C-associated protein kinase 1
    serine/threonine-protein kinase p78
    NP_001122390.1
    NP_001122391.1
    NP_001122392.1
    NP_001122393.1
    NP_002367.4
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030339.1 RefSeqGene

      Range
      5001..123468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001128918.1 → NP_001122390.1  MAP/microtubule affinity-regulating kinase 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AF465413, AL133367, BC024773, BX248250, DA707357
      Consensus CDS
      CCDS45165.1
      UniProtKB/Swiss-Prot
      P27448
      UniProtKB/TrEMBL
      Q86U11
      Related
      ENSP00000411397, OTTHUMP00000246865, ENST00000429436, OTTHUMT00000415144
      Conserved Domains (4) summary
      cd00194
      Location:328 – 365
      Blast Score: 103
      UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...
      cd05123
      Location:62 – 306
      Blast Score: 675
      STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
      pfam02149
      Location:708 – 753
      Blast Score: 181
      KA1; Kinase associated domain 1
      smart00220
      Location:56 – 307
      Blast Score: 879
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    2. NM_001128919.1 → NP_001122391.1  MAP/microtubule affinity-regulating kinase 3 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AF387637, AL133367, BC024773, BX248250, DA707357
      Consensus CDS
      CCDS45166.1
      UniProtKB/Swiss-Prot
      P27448
      UniProtKB/TrEMBL
      Q86U11
      Related
      ENSP00000450772, OTTHUMP00000246868, ENST00000553942, OTTHUMT00000415147
      Conserved Domains (4) summary
      cd00194
      Location:328 – 365
      Blast Score: 103
      UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...
      cd05123
      Location:62 – 306
      Blast Score: 675
      STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
      pfam02149
      Location:699 – 744
      Blast Score: 182
      KA1; Kinase associated domain 1
      smart00220
      Location:56 – 307
      Blast Score: 880
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    3. NM_001128920.1 → NP_001122392.1  MAP/microtubule affinity-regulating kinase 3 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AL133367, BC024773, BX248250, DA707357, M80359
      Consensus CDS
      CCDS55947.1
      UniProtKB/Swiss-Prot
      P27448
      UniProtKB/TrEMBL
      Q86U11
      Related
      ENSP00000216288, OTTHUMP00000246867, ENST00000216288, OTTHUMT00000415146
      Conserved Domains (5) summary
      cd00194
      Location:328 – 365
      Blast Score: 103
      UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...
      cd05123
      Location:62 – 306
      Blast Score: 676
      STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
      PHA03307
      Location:358 – 600
      Blast Score: 100
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam02149
      Location:668 – 713
      Blast Score: 182
      KA1; Kinase associated domain 1
      smart00220
      Location:56 – 307
      Blast Score: 880
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    4. NM_001128921.1 → NP_001122393.1  MAP/microtubule affinity-regulating kinase 3 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BC024773, BX161395, BX248250, DA707357
      Consensus CDS
      CCDS45167.1
      UniProtKB/Swiss-Prot
      P27448
      UniProtKB/TrEMBL
      Q86U11
      Related
      ENSP00000402104, OTTHUMP00000246863, ENST00000440884, OTTHUMT00000415142
      Conserved Domains (4) summary
      cd00194
      Location:249 – 286
      Blast Score: 103
      UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...
      cd00180
      Location:62 – 180
      Blast Score: 389
      PKc; Catalytic domain of Protein Kinases
      pfam02149
      Location:614 – 659
      Blast Score: 181
      KA1; Kinase associated domain 1
      cl09925
      Location:176 – 227
      Blast Score: 105
      PKc_like; Protein Kinases, catalytic domain

    5. NM_002376.5 → NP_002367.4  MAP/microtubule affinity-regulating kinase 3 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AL133367, BC024773, BX248250, DA707357
      Consensus CDS
      CCDS41993.1
      UniProtKB/Swiss-Prot
      P27448
      UniProtKB/TrEMBL
      Q86U11
      Related
      ENSP00000303698, OTTHUMP00000246866, ENST00000303622, OTTHUMT00000415145
      Conserved Domains (5) summary
      cd00194
      Location:328 – 365
      Blast Score: 103
      UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...
      cd05123
      Location:62 – 306
      Blast Score: 675
      STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
      PHA03307
      Location:425 – 616
      Blast Score: 93
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam02149
      Location:684 – 729
      Blast Score: 182
      KA1; Kinase associated domain 1
      smart00220
      Location:56 – 307
      Blast Score: 880
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000014.8 Reference GRCh37.p5 Primary Assembly

      Range
      103851701..103970168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000146.1 Alternate HuRef

      Range
      84029889..84148541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL133367.4 (32459..150856) None
    genomic CH471061.1 EAW81812.1
      EAW81813.1
      EAW81814.1
      EAW81815.1
      EAW81816.1
      EAW81817.1
      EAW81818.1
      EAW81819.1
    mRNA AB209542.1 BAD92779.1
    mRNA AF170723.1 AAD51631.1
    mRNA AF387637.1 AAK82367.1
    mRNA AF465413.1 AAL69982.1
    mRNA AK124459.1 None
    mRNA AK296643.1 BAG59243.1
    mRNA AK307448.1 None
    mRNA BC024773.1 AAH24773.1
    mRNA BX161395.1 CAD61882.1
    mRNA BX248250.1 CAD62578.1
    mRNA DA707357.1 None
    mRNA DQ368336.1 ABD15137.1
    mRNA M80359.1 AAA59991.1
    mRNA M83780.1 None
    mRNA U64205.1 AAC15093.1
    other-genetic DQ891715.2 ABM82641.1
    other-genetic DQ894892.2 ABM85818.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27448.4 GenPept UniProtKB/Swiss-Prot:P27448
    Q59FB8 GenPept UniProtKB/TrEMBL:Q59FB8
    Q86U11 GenPept UniProtKB/TrEMBL:Q86U11
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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