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    Csk C-terminal Src kinase [ Drosophila melanogaster ]

    Gene ID: 41398, updated on 10-May-2012
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    Summary

    Official Symbol
    Cskprovided by Flybase
    Official Full Name
    C-terminal Src kinaseprovided by Flybase
    Primary source
    FLYBASE:FBgn0262081
    Locus tag
    Dmel_CG42317
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17309; CG32852; CG42317; csk; CSK; dcsk; dCsk; dCSK; DCsk; Dmel\CG42317; flik; l(3)j1D8; l(3)S017909
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    Genomic context

    Location :
    86E13-86E
    Sequence :
    Chromosome: 3R; NT_033777.2 (7458992..7476418, complement)
    See Csk in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene CG6808 gene product from transcript CG6808-RA Neighboring gene CG6813 gene product from transcript CG6813-RB Neighboring gene CG18764 gene product from transcript CG18764-RA Neighboring gene CG14712 gene product from transcript CG14712-RA Neighboring gene Elongator complex protein 1 Neighboring gene CG42327 gene product from transcript CG42327-RE

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Identifying cellular pathways modulated by Drosophila palmitoyl-protein thioesterase 1 function. Saja S, et al. Neurobiol Dis, 2010 Oct. PMID 20206262.
    2. The dASPP-dRASSF8 complex regulates cell-cell adhesion during Drosophila retinal morphogenesis. Langton PF, et al. Curr Biol, 2009 Dec 15. PMID 19931458.
    3. Silencing by small RNAs is linked to endosomal trafficking. Lee YS, et al. Nat Cell Biol, 2009 Sep. PMID 19684574.
    4. Drosophila as a model for human diseases: IRB and ICREA, Barcelona, Spain, October 5-7, 2006. Tountas NA, et al. Fly (Austin), 2007 Jan-Feb. PMID 18690062.
    5. Genetic and chemical modifiers of a CUG toxicity model in Drosophila. Garcia-Lopez A, et al. PLoS One, 2008 Feb 13. PMID 18270582.

    See all (31) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis.
      Title: Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis.
    2. Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways
      Title: Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways.
    3. Results demonstrate that regulation of Src64 by Drosophila C-terminal-Src Kinase (Csk) contributes to the packaging of germline cysts by overlying somatic follicle cells during egg chamber formation.
      Title: Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells.
    4. C-terminal Src kinase (CSK) in Drosophila was identified in a genetic modifier screen for genes that interact with the lats tumor suppressor gene. CSK regulates cell proliferation and organ size.
      Title: A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:66526 BioGRID:67008 Akt1    BioGRID  PubMed Two-hybrid 
    BioGRID:66526 BioGRID:57560 CG13373    BioGRID  PubMed Two-hybrid 
    BioGRID:66526 BioGRID:61707 CG14744    BioGRID  PubMed Two-hybrid 
    BioGRID:66526 BioGRID:58015 CG15764    BioGRID  PubMed Two-hybrid 
    BioGRID:66526 BioGRID:63359 CG15800    BioGRID  PubMed Two-hybrid 
    BioGRID:66526 BioGRID:72816 CG18754    BioGRID  PubMed Two-hybrid 
    BioGRID:66526 BioGRID:58854 CG8128    BioGRID  PubMed Two-hybrid 
    BioGRID:66526 BioGRID:62567 Cdk4    BioGRID  PubMed Two-hybrid 
    BioGRID:66526 BioGRID:62461 Cdk5    BioGRID  PubMed Two-hybrid 
    BioGRID:66526 BioGRID:68567 CycG    BioGRID  PubMed Two-hybrid 
    BioGRID:66526 BioGRID:61336 E2f2    BioGRID  PubMed Two-hybrid 
    BioGRID:66526 BioGRID:61733 FANCI    BioGRID  PubMed Two-hybrid 
    BioGRID:66526 BioGRID:61322 RPA2    BioGRID  PubMed Two-hybrid 
    BioGRID:66526 BioGRID:68766 Sucb    BioGRID  PubMed Two-hybrid 
    BioGRID:66526 BioGRID:67231 koko    BioGRID  PubMed Two-hybrid 
    BioGRID:66526 BioGRID:68973 pie    BioGRID  PubMed Two-hybrid 
    BioGRID:66526 BioGRID:61701 ptc    BioGRID  PubMed Two-hybrid 
    BioGRID:66526 BioGRID:65883 rev7    BioGRID  PubMed Two-hybrid 
    BioGRID:66526 BioGRID:58031 rux    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the Csk gene: The Csk gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, and C.elegans.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase activity NAS
    Non-traceable Author Statement
    more info
    		  
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein tyrosine kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    adherens junction maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    epithelial structure maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    establishment or maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    germarium-derived egg chamber formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of cell proliferation NAS
    Non-traceable Author Statement
    more info
    		  
    negative regulation of growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    negative regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    signal transduction NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CG42317 gene product from transcript CG42317-RG
    Names
    C-Src kinase
    C-terminal Src kinase
    C-terminal-Src kinase
    CG42317-PF
    CG42317-PG
    CG42317-PH
    CG42317-PI
    CG42317-PJ
    CG42317-PK
    Csk-PF
    Csk-PG
    Csk-PH
    Csk-PI
    Csk-PJ
    Csk-PK
    flik
    lethal (3) S017909
    lethal (3) j1D8
    NP_650097.2
    NP_731607.1
    NP_731608.1
    NP_731609.1
    NP_731611.2
    NP_788638.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      7458992..7476418, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169418.2 → NP_731611.2  C-terminal Src kinase, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INJ8
      Related
      FBpp0289007, FBtr0299729
      Conserved Domains (3) summary
      cd05039
      Location:793 – 1047
      Blast Score: 1294
      PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases
      smart00221
      Location:800 – 1044
      Blast Score: 928
      STYKc; Protein kinase; unclassified specificity.
      cd09937
      Location:680 – 777
      Blast Score: 527
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

    2. NM_169414.1 → NP_731607.1  C-terminal Src kinase, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSQ2
      Related
      FBpp0289774, FBtr0300547
      Conserved Domains (3) summary
      cd05039
      Location:464 – 718
      Blast Score: 1286
      PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases
      smart00221
      Location:471 – 715
      Blast Score: 918
      STYKc; Protein kinase; unclassified specificity.
      cd09937
      Location:351 – 448
      Blast Score: 525
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

    3. NM_141840.1 → NP_650097.2  C-terminal Src kinase, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGK8
      Related
      FBpp0289773, FBtr0300546
      Conserved Domains (3) summary
      cd05039
      Location:546 – 800
      Blast Score: 1291
      PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases
      smart00221
      Location:553 – 797
      Blast Score: 923
      STYKc; Protein kinase; unclassified specificity.
      cd09937
      Location:433 – 530
      Blast Score: 527
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

    4. NM_176461.1 → NP_788638.1  C-terminal Src kinase, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSQ2
      Related
      FBpp0289006, FBtr0299728
      Conserved Domains (3) summary
      cd05039
      Location:464 – 718
      Blast Score: 1286
      PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases
      smart00221
      Location:471 – 715
      Blast Score: 918
      STYKc; Protein kinase; unclassified specificity.
      cd09937
      Location:351 – 448
      Blast Score: 525
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

    5. NM_169415.2 → NP_731608.1  C-terminal Src kinase, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSQ2
      Related
      FBpp0289775, FBtr0300548
      Conserved Domains (3) summary
      cd05039
      Location:464 – 718
      Blast Score: 1286
      PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases
      smart00221
      Location:471 – 715
      Blast Score: 918
      STYKc; Protein kinase; unclassified specificity.
      cd09937
      Location:351 – 448
      Blast Score: 525
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

    6. NM_169416.2 → NP_731609.1  C-terminal Src kinase, isoform K [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSQ2
      Related
      FBpp0289776, FBtr0300549
      Conserved Domains (3) summary
      cd05039
      Location:464 – 718
      Blast Score: 1286
      PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases
      smart00221
      Location:471 – 715
      Blast Score: 918
      STYKc; Protein kinase; unclassified specificity.
      cd09937
      Location:351 – 448
      Blast Score: 525
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014297.2 AAN13523.2
    genomic AE014297.2 AAN13521.1
    genomic AE014297.2 AAO41544.1
    genomic AE014297.2 AAN13519.1
    genomic AE014297.2 AAN13520.1
    genomic AE014297.2 AAF54668.3
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAF54668.2 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content