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    MAP4 microtubule-associated protein 4 [ Homo sapiens ]

    Gene ID: 4134, updated on 19-May-2012

    Summary

    Official Symbol
    MAP4provided by HGNC
    Official Full Name
    microtubule-associated protein 4provided by HGNC
    Primary source
    HGNC:6862
    See related
    Ensembl:ENSG00000047849; HPRD:01141; MIM:157132; Vega:OTTHUMG00000156828
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MGC8617; DKFZp779A1753
    Summary
    The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

    Genomic context

    Location :
    3p21
    Sequence :
    Chromosome: 3; NC_000003.11 (47892180..48130769, complement)
    See MAP4 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 30 Neighboring gene microRNA 1226 Neighboring gene vacuolar protein sorting 26 homolog B (S. pombe) pseudogene Neighboring gene ribosomal protein L17 pseudogene 16 Neighboring gene cell division cycle 25 homolog A (S. pombe) Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1 pseudogene 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002366.1 Cyclin B1 CCNB1    HPRD  PubMed  
    NP_002366.1 NP_113605.2 MARK4    HPRD  PubMed  
    NP_002366.1 Tubulin, beta TUBB    HPRD  PubMed  
    P27816 P14635 CCNB1    HPRD  PubMed  
    P27816 P06493 CDK1    HPRD  PubMed  
    P27816 P09104 ENO2    HPRD  PubMed  
    P27816 Q9P0L2 MARK1    HPRD  PubMed  
    P27816 Q96L34 MARK4    HPRD  PubMed  
    P27816 Q14994 NR1I3    HPRD  PubMed  
    P27816 P28702 RXRB    HPRD  PubMed  
    P27816 P48443 RXRG    HPRD  PubMed  
    P27816 P07437 TUBB    HPRD  PubMed  
    BioGRID:110306 BioGRID:107420 CDK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:110306 BioGRID:108340 ENO2    BioGRID  PubMed Two-hybrid 
    BioGRID:110306 BioGRID:122669 FYCO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110306 BioGRID:109187 GSK3B    BioGRID  PubMed Two-hybrid 
    BioGRID:110306 BioGRID:109318 HDGF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110306 BioGRID:121760 MARK4    BioGRID  PubMed Biochemical Activity 
    BioGRID:110306 BioGRID:115295 NR1I3    BioGRID  PubMed Two-hybrid 
    BioGRID:110306 BioGRID:112169 RXRB    BioGRID  PubMed Two-hybrid 
    BioGRID:110306 BioGRID:112170 RXRG    BioGRID  PubMed Two-hybrid 
    BioGRID:110306 BioGRID:113188 SUMO1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110306 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural molecule activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of microtubule depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule associated complex TAS
    Traceable Author Statement
    more info
    PubMed 
    microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    microtubule-associated protein 4
    Names
    microtubule-associated protein 4
    MAP-4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134364.1NP_001127836.1  microtubule-associated protein 4 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA904866, AB209377, DA114613, DC343259
      Consensus CDS
      CCDS46818.1
      UniProtKB/Swiss-Prot
      P27816
      Related
      ENSP00000379083, OTTHUMP00000210726, ENST00000395734, OTTHUMT00000346090
      Conserved Domains (1) summary
      pfam00418
      Location:9921022
      Blast Score: 150
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    2. NM_002375.4NP_002366.2  microtubule-associated protein 4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. It encodes the longest isoform (1).
      Source sequence(s)
      AA904866, AB209377, DA114613, DC343259, M64571
      Consensus CDS
      CCDS33750.1
      UniProtKB/Swiss-Prot
      P27816
      Related
      ENSP00000353375, OTTHUMP00000210722, ENST00000360240, OTTHUMT00000346085
      Conserved Domains (1) summary
      pfam00418
      Location:9921022
      Blast Score: 149
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    3. NM_030885.3NP_112147.2  microtubule-associated protein 4 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks multiple exons in the 3' region and uses an unique splice site at the 3' end-exon compared to variant 1. The resulting isoform (3) has a distinct and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AA206810, AI078534, BC051843, DA114613, DA150735, DC343259
      Consensus CDS
      CCDS46821.1
      Related
      ENSP00000397414, OTTHUMP00000210723, ENST00000439356, OTTHUMT00000346087

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      47892180..48130769, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      47947535..48185502, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001134365.1: Suppressed sequence

      Description
      NM_001134365.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_030884.3: Suppressed sequence

      Description
      NM_030884.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

      Supplemental Content

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