MAOB monoamine oxidase B [Homo sapiens] - Gene

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Summary

Official Symbol: MAOBprovided by HGNC
Official Full Name: monoamine oxidase Bprovided by HGNC
Primary source: HGNC:6834
Locus tag: RP1-201D17__B.1
See related: Ensembl:ENSG00000069535; HPRD:02401; MIM:309860; Vega:OTTHUMG00000021388
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MGC26382
Summary: The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: Xp11.23

Sequence :: Chromosome: X; NC_000023.10 (43625857..43741721, complement)

See MAOB in Epigenomics, MapViewer

Chromosome X - NC_000023.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results suggest MAOB is a susceptibility gene for schizophrenia in Han Chinese.
Title: Association study of monoamine oxidase A/B genes and schizophrenia in Han Chinese.
results demonstrate that the bipartite cavity structure in MAO B plays an important role in substrate and inhibitor recognition to distinguish its specificities from those of MAO A
Title: The 'gating' residues Ile199 and Tyr326 in human monoamine oxidase B function in substrate and inhibitor recognition.
Nitrogen kinetic isotope effects for the oxidation of benzylamine and (1,1-(2)H(2))benzylamine by recombinant human monoamine oxidase B show that cleavage of the CH bond is not concerted with rehybridization of the nitrogen atom.
Title: Nitrogen kinetic isotope effects for the monoamine oxidase B-catalyzed oxidation of benzylamine and (1,1-(2)H2)benzylamine: nitrogen rehybridization and CH bond cleavage are not concerted.
mutation in gene encoding the monoamine degradation enzyme monoamine oxidase B was found in SCZ.
Title: Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia.
COMT rs4680 and MAOB rs1799836 polymorphisms may increase susceptibility to Parkinson's disease risk among Japanese
Title: Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population.
Quantitative enzyme radioautography reveals increased MAO-A and -B in Huntington's disease.
Title: Up-regulation of the isoenzymes MAO-A and MAO-B in the human basal ganglia and pons in Huntington's disease revealed by quantitative enzyme radioautography.
Parkin degrades ESRRA, ESRRB and ESRRG to limit the expression of MAOA and MAOB.
Title: Parkin degrades estrogen-related receptors to limit the expression of monoamine oxidases.
In early stage Alzheimer disease, discrete MAO-B reduction reflects the capacity of the population of MAO-B-positive progenitor cells to adapt to the neurodegenerative process.
Title: Alzheimer's disease modifies progenitor cell expression of monoamine oxidase B in the subventricular zone.
identified a 240 kb deletion on Xp11.3-p11.4, encompassing MAOA and MAOB but does not affect the adjacent Norrie disease gene;the brothers with the deletion presented with developmental delay, intermittent hypotonia and stereotypical hand movements
Title: Deletion of MAOA and MAOB in a male patient causes severe developmental delay, intermittent hypotonia and stereotypical hand movements.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Submit: New GeneRIF Correction See all (69)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
P27338	P27338	MAOB		HPRD	PubMed
BioGRID:110302	BioGRID:113164	UBC		BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western

Function	Evidence Code	Pubs
electron carrier activity	TAS Traceable Author Statement more info	PubMed
flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
oxidoreductase activity	IEA Inferred from Electronic Annotation more info
primary amine oxidase activity	TAS Traceable Author Statement more info
protein homodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
negative regulation of serotonin secretion	IEA Inferred from Electronic Annotation more info
positive regulation of dopamine metabolic process	IEA Inferred from Electronic Annotation more info
response to aluminum ion	IEA Inferred from Electronic Annotation more info
response to corticosterone stimulus	IEA Inferred from Electronic Annotation more info
response to drug	IEA Inferred from Electronic Annotation more info
response to ethanol	IEA Inferred from Electronic Annotation more info
response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
response to selenium ion	IEA Inferred from Electronic Annotation more info
response to steroid hormone stimulus	IEA Inferred from Electronic Annotation more info
response to toxin	IEA Inferred from Electronic Annotation more info
small molecule metabolic process	TAS Traceable Author Statement more info
xenobiotic metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
mitochondrial envelope	TAS Traceable Author Statement more info	PubMed
mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
mitochondrial outer membrane	TAS Traceable Author Statement more info
mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: amine oxidase [flavin-containing] B

Names: amine oxidase [flavin-containing] B; MAO-B; MAO, brain; MAO, platelet; tyramine oxidase; adrenalin oxidase; monoamine oxidase type B

NP_000889.3

EC 1.4.3.4

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008723.1 RefSeqGene

Range

5001..120865

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000898.4 → NP_000889.3 amine oxidase [flavin-containing] B

Status: REVIEWED

Source sequence(s)

AL133791, BM726427, DC326844, M69177

Consensus CDS

CCDS14261.1

UniProtKB/Swiss-Prot

P27338

Related

ENSP00000367309, OTTHUMP00000023166, ENST00000378069, OTTHUMT00000056303

Conserved Domains (2) summary

COG1231
Location:5 – 436
Blast Score: 607

COG1231; Monoamine oxidase [Amino acid transport and metabolism]

cl09931
Location:9 – 75
Blast Score: 174

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000023.10 Reference GRCh37.p5 Primary Assembly

Range

43625857..43741721, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000155.1 Alternate HuRef

Range

41355388..41470732, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL008709.1	CAD92552.2
genomic	BX537148.1	CAI42422.1
genomic	CH471141.2	EAW59378.1
		EAW59379.1
		EAW59380.1
genomic	M69135.1	AAA59551.1
genomic	M89637.1	AAB46386.1
genomic	Z95125.1	CAI42522.1
mRNA	AK294306.1	BAH11728.1
mRNA	AK298942.1	BAH12909.1
mRNA	AK310458.1	None
mRNA	AK312679.1	BAG35560.1
mRNA	AL133791.1	None
mRNA	AU127841.1	None
mRNA	BC022494.1	AAH22494.1
mRNA	BM726427.1	None
mRNA	CA975968.1	None
mRNA	DC326844.1	None
mRNA	M69177.1	AAA59550.1
mRNA	S62734.1	AAB27229.1
other-genetic	GQ129432.1	ACT64566.1
other-genetic	GQ129433.1	ACT64567.1