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    MAOB monoamine oxidase B [ Homo sapiens (human) ]

    Gene ID: 4129, updated on 15-Jun-2013
    Official Symbol
    MAOBprovided by HGNC
    Official Full Name
    monoamine oxidase Bprovided by HGNC
    Primary source
    HGNC:6834
    Locus tag
    RP1-201D17__B.1
    See related
    Ensembl:ENSG00000069535; HPRD:02401; MIM:309860; Vega:OTTHUMG00000021388
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]
    Location :
    Xp11.23
    Sequence :
    Chromosome: X; NC_000023.10 (43625857..43741721, complement)
    See MAOB in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene Nanog homeobox pseudogene 10 Neighboring gene monoamine oxidase A Neighboring gene Norrie disease (pseudoglioma) Neighboring gene RNA binding motif protein 39 pseudogene

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. G/A polymorphism in intronic sequence affects the processing of MAO-B gene in patients with Parkinson disease. Jakubauskiene E, et al. FEBS Lett, 2012 Oct 19. PMID 22974659.
    2. Investigating association of four gene regions (GABRB3, MAOB, PAH, and SLC6A4) with five symptoms in schizophrenia. Sun J, et al. Psychiatry Res, 2012 Jul 30. PMID 22414661.
    3. Comparative platelet proteome analysis reveals an increase of monoamine oxidase-B protein expression in Alzheimer's disease but not in non-demented Parkinson's disease patients. Zellner M, et al. J Proteomics, 2012 Apr 3. PMID 22270014.
    4. Toward an understanding of the protein interaction network of the human liver. Wang J, et al. Mol Syst Biol, 2011 Oct 11. PMID 21988832.
    5. Association study of monoamine oxidase A/B genes and schizophrenia in Han Chinese. Wei YL, et al. Behav Brain Funct, 2011 Oct 6. PMID 21978760.

    See all (135) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. results provide additional evidence that GABRB3 and MAOB/NDP gene regions might constitute risk factors for hallucinations and delusions in schizophrenia.
      Title: Investigating association of four gene regions (GABRB3, MAOB, PAH, and SLC6A4) with five symptoms in schizophrenia.
    2. G/A dimorphism in intron 13 sequence creates splicing enhancer thus stimulating intron 13 removal efficiency
      Title: G/A polymorphism in intronic sequence affects the processing of MAO-B gene in patients with Parkinson disease.
    3. The presence of a short 5HTT-LPR or short MAOA-variable number of tandem repeats allele, in combination with high levels of platelet MAOB enzyme activity was associated with higher scores of attention-deficit hyperactivity disorder-like problems.
      Title: Associations of MAOA-VNTR or 5HTT-LPR alleles with attention-deficit hyperactivity disorder symptoms are moderated by platelet monoamine oxidase B activity.
    4. [review] While MAO-B primarily serves in the catabolism of 2-phenylethylamine and contributes to the degradation of other trace amines and dopamine, MAO-A has high affinity for serotonin and norepinephrine.
      Title: Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence.
    5. [review] Although the crystal structure of human MAO-A is monomeric while MAO-B is dimeric, both enzymes are dimeric in their membrane-bound forms.
      Title: Structural properties of human monoamine oxidases A and B.
    6. Mao-B platelet protein level may serve as a biomarker for age-related dementia, especially AD.
      Title: Comparative platelet proteome analysis reveals an increase of monoamine oxidase-B protein expression in Alzheimer's disease but not in non-demented Parkinson's disease patients.
    7. [review] A better understanding of the transcriptional regulation of MAO B may help explain the differential tissue-specific expression of the two isoenzymes and provide insights into the molecular basis of the disorders associated with MAO dysfunction.
      Title: Transcriptional regulation and multiple functions of MAO genes.
    8. Results suggest MAOB is a susceptibility gene for schizophrenia in Han Chinese.
      Title: Association study of monoamine oxidase A/B genes and schizophrenia in Han Chinese.
    9. results demonstrate that the bipartite cavity structure in MAO B plays an important role in substrate and inhibitor recognition to distinguish its specificities from those of MAO A
      Title: The 'gating' residues Ile199 and Tyr326 in human monoamine oxidase B function in substrate and inhibitor recognition.
    10. Nitrogen kinetic isotope effects for the oxidation of benzylamine and (1,1-(2)H(2))benzylamine by recombinant human monoamine oxidase B show that cleavage of the CH bond is not concerted with rehybridization of the nitrogen atom.
      Title: Nitrogen kinetic isotope effects for the monoamine oxidase B-catalyzed oxidation of benzylamine and (1,1-(2)H2)benzylamine: nitrogen rehybridization and CH bond cleavage are not concerted.
    Submit: New GeneRIF Correction See all (76)

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    P27338 P27338 MAOB    HPRD  PubMed  
    BioGRID:110302 BioGRID:199230 Dlg4    BioGRID  PubMed Protein-peptide 
    BioGRID:110302 BioGRID:110867 NFYB    BioGRID  PubMed Two-hybrid 
    BioGRID:110302 BioGRID:112610 SRPK1    BioGRID  PubMed Two-hybrid 
    BioGRID:110302 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC26382

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    electron carrier activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    primary amine oxidase activity TAS
    Traceable Author Statement
    more info
    		  
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    negative regulation of serotonin secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of dopamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to aluminum ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to corticosterone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to drug IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to selenium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
    		  
    xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial envelope TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    		  
    Preferred Names
    amine oxidase [flavin-containing] B
    Names
    amine oxidase [flavin-containing] B
    MAO-B
    MAO, brain
    MAO, platelet
    tyramine oxidase
    adrenalin oxidase
    monoamine oxidase type B
    NP_000889.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008723.1 RefSeqGene

      Range
      5001..120865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000898.4 → NP_000889.3  amine oxidase [flavin-containing] B

      Status: REVIEWED

      Source sequence(s)
      AL133791, BM726427, DC326844, M69177
      Consensus CDS
      CCDS14261.1
      UniProtKB/Swiss-Prot
      P27338
      Related
      ENSP00000367309, OTTHUMP00000023166, ENST00000378069, OTTHUMT00000056303
      Conserved Domains (2) summary
      COG1231
      Location:5 – 436
      Blast Score: 607
      COG1231; Monoamine oxidase [Amino acid transport and metabolism]
      pfam13450
      Location:9 – 75
      Blast Score: 174
      NAD_binding_8; NAD(P)-binding Rossmann-like domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p10 Primary Assembly

      Range
      43625857..43741721, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000155.1 Alternate HuRef

      Range
      41355388..41470732, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018934.1 Alternate CHM1_1.0

      Range
      43544393..43660254, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01046436.1 (3087..31747) None
    genomic ABBA01046437.1 None
    genomic ABBA01046438.1 None
    genomic ABBA01046439.1 None
    genomic ABBA01046440.1 None
    genomic ABBA01046441.1 None
    genomic ABBA01046442.1 None
    genomic ABBA01046443.1 None
    genomic ABBA01046444.1 None
    genomic ABBA01046445.1 None
    genomic ABBA01046446.1 None
    genomic AL008709.1 (2000..66735) None
    genomic AMYH01022239.1 (457748..573609) None
    genomic BX537148.1 (35247..43385) None
    genomic CH471141.2 EAW59378.1
      EAW59379.1
      EAW59380.1
    genomic M69135.1 AAA59551.1
    genomic M89637.1 AAB46386.1
    genomic Z95125.1 (37404..80393) None
    mRNA AK294306.1 BAH11728.1
    mRNA AK298942.1 BAH12909.1
    mRNA AK310458.1 None
    mRNA AK312679.1 BAG35560.1
    mRNA AL133791.1 None
    mRNA AU127841.1 None
    mRNA BC022494.1 AAH22494.1
    mRNA BM726427.1 None
    mRNA CA975968.1 None
    mRNA DC326844.1 None
    mRNA M69177.1 AAA59550.1
    mRNA S62734.1 AAB27229.1
    other-genetic GQ129432.1 ACT64566.1
    other-genetic GQ129433.1 ACT64567.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27338.3 GenPept UniProtKB/Swiss-Prot:P27338

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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      Supplemental Content

      Table of contents

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        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
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        Link to Protein RefSeqs
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        Link to related taxonomy entry
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      • UniSTS
        Related UniSTS records

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