MAOA monoamine oxidase A [Homo sapiens] - Gene

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Summary

Official Symbol: MAOAprovided by HGNC
Official Full Name: monoamine oxidase Aprovided by HGNC
Primary source: HGNC:6833
Locus tag: RP1-201D17__B.2
See related: Ensembl:ENSG00000189221; HPRD:02400; MIM:309850; Vega:OTTHUMG00000021387
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes monoamine oxidase A, an enzyme that degrades amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. The protein localizes to the mitochondrial outer membrane. The gene is adjacent to a related gene on the opposite strand of chromosome X. Mutation in this gene results in monoamine oxidase deficiency, or Brunner syndrome. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: Xp11.3

Sequence :: Chromosome: X; NC_000023.10 (43515409..43606068)

See MAOA in Epigenomics, MapViewer

Chromosome X - NC_000023.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The monomanine oxidase A promoter length polymorphism is an important risk factor in the development of sudden infant death syndrome.
Title: Association between a functional polymorphism in the MAOA gene and sudden infant death syndrome.
The interaction between genetic variants within the MAOA gene may contribute to an increased risk of paranoid schizophrenia.
Title: Study of a possible role of the monoamine oxidase A (MAOA) gene in paranoid schizophrenia among a Chinese population.
The vntr region of MAOA is genetic linking to working memory performance.
Title: Serotonergic modulation in executive functioning: linking genetic variations to working memory performance.
results indicated that regulatory behavior was associated with the functional MAOA gene polymorphism in girls, but not boys
Title: The association between infants' self-regulatory behavior and MAOA gene polymorphism.
No significant associations were observed for the MAOA functional polymorphism with schizophrenia in Han Chinese.
Title: Association study of monoamine oxidase A/B genes and schizophrenia in Han Chinese.
our results provide some evidence that MAOA may be associated with the ADHD-HI subtype and support the association between MAOA and impulsivity, which may be a potential endophenotype of ADHD.
Title: Association analyses of MAOA in Chinese Han subjects with attention-deficit/hyperactivity disorder: family-based association test, case-control study, and quantitative traits of impulsivity.
significant effects of the 5-HTTLPR and MAOA-EcoRV polymorphisms on the attentional dimension of trait EI were observed in males.
Title: The effects of serotonin transporter promoter and monoamine oxidase A gene polymorphisms on trait emotional intelligence.
The MAOA gene is located on chromosome X and due to its role in metabolism of both catecholamine and serotonin, a connection to autism is plausible.
Title: MAOA, DBH, and SLC6A4 variants in CHARGE: a case-control study of autism spectrum disorders.
Sequence analysis, electrophoretic mobility shift and chromatin immunoprecipitation assays showed the presence of a functional FoxO1-binding site in monoamine oxidase A core promoter.
Title: Valproic acid induces monoamine oxidase A via Akt/forkhead box O1 activation.
Quantitative enzyme radioautography reveals increased MAO-A and -B in Huntington's disease.
Title: Up-regulation of the isoenzymes MAO-A and MAO-B in the human basal ganglia and pons in Huntington's disease revealed by quantitative enzyme radioautography.

Submit: New GeneRIF Correction See all (215)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide and candidate gene association study of cigarette smoking behaviors.

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Products	Interactant	Other Gene	Source	Pubs	Description
P21397	P21397	MAOA	HPRD	PubMed
P21397	Q92597	NDRG1	HPRD	PubMed
BioGRID:110301	BioGRID:115669	NDRG1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110301	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western

Function	Evidence Code	Pubs
flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
oxidoreductase activity	IEA Inferred from Electronic Annotation more info
primary amine oxidase activity	TAS Traceable Author Statement more info
serotonin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
behavior	TAS Traceable Author Statement more info	PubMed
catecholamine metabolic process	IEA Inferred from Electronic Annotation more info
cellular biogenic amine metabolic process	TAS Traceable Author Statement more info	PubMed
dopamine catabolic process	IEA Inferred from Electronic Annotation more info
neurotransmitter biosynthetic process	TAS Traceable Author Statement more info
neurotransmitter catabolic process	IEA Inferred from Electronic Annotation more info
neurotransmitter secretion	TAS Traceable Author Statement more info
phenylethylamine metabolic process	IEA Inferred from Electronic Annotation more info
serotonin metabolic process	IEA Inferred from Electronic Annotation more info
small molecule metabolic process	TAS Traceable Author Statement more info
synaptic transmission	TAS Traceable Author Statement more info
xenobiotic metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
mitochondrial outer membrane	TAS Traceable Author Statement more info
mitochondrion	IEA Inferred from Electronic Annotation more info
soluble fraction	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: amine oxidase [flavin-containing] A

Names: amine oxidase [flavin-containing] A; MAO-A; monoamine oxidase type A

NP_000231.1

EC 1.4.3.4

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008957.1 RefSeqGene

Range

5001..95660

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000240.2 → NP_000231.1 amine oxidase [flavin-containing] A

Status: REVIEWED

Source sequence(s)

BC008064, BG534382, BU684121, BX501303, X60819

Consensus CDS

CCDS14260.1

UniProtKB/Swiss-Prot

P21397

UniProtKB/TrEMBL

Q53YE7

Related

ENSP00000340684, OTTHUMP00000023165, ENST00000338702, OTTHUMT00000056300

Conserved Domains (2) summary

pfam01593
Location:24 – 445
Blast Score: 582

Amino_oxidase; Flavin containing amine oxidoreductase

cl09931
Location:24 – 58
Blast Score: 126

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000023.10 Reference GRCh37.p5 Primary Assembly

Range

43515409..43606068

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000155.1 Alternate HuRef

Range

41246066..41335633

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL109855.17 (47718..80291)	None
genomic	AY684850.1	AAV34705.1
genomic	AY684858.1	AAV34711.1
genomic	AY685682.1	AAV34717.1
genomic	AY685685.1	AAV34720.1
genomic	BX530072.8	CAI43216.1
genomic	BX537147.1	CAI42421.1
genomic	BX537148.1	CAI42424.1
genomic	CH471141.2	EAW59381.1
		EAW59382.1
		EAW59383.1
genomic	M68845.1	AAA59547.1
genomic	M68857.1	AAA59547.1
genomic	M89636.1	AAB46385.1
genomic	S72704.1	AAD14113.1
genomic	S81371.1	AAD14361.1
genomic	X60811.1	None
genomic	X60813.1	None
genomic	X60819.1	None
mRNA	AK223499.1	BAD97219.1
mRNA	AK291769.1	BAF84458.1
mRNA	AK293926.1	BAG57307.1
mRNA	BC008064.2	AAH08064.1
mRNA	BC044787.1	AAH44787.1
mRNA	BG534382.1	None
mRNA	BT006651.1	AAP35297.1
mRNA	BU684121.1	None
mRNA	BX501303.1	None
mRNA	M68840.1	AAA59548.1
mRNA	M69226.1	AAA59549.1
mRNA	X17192.1	None
other-genetic	DQ890676.2	ABM81602.1
other-genetic	DQ893857.2	ABM84783.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P21397.1	GenPept	UniProtKB/Swiss-Prot:P21397
Q49A63	GenPept	UniProtKB/TrEMBL:Q49A63
Q53EZ0	GenPept	UniProtKB/TrEMBL:Q53EZ0
Q5UL91	GenPept	UniProtKB/TrEMBL:Q5UL91
Q5UL94	GenPept	UniProtKB/TrEMBL:Q5UL94
Q5ULA3	GenPept	UniProtKB/TrEMBL:Q5ULA3
Q5ULA9	GenPept	UniProtKB/TrEMBL:Q5ULA9