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    MAN2A2 mannosidase, alpha, class 2A, member 2 [ Homo sapiens ]

    Gene ID: 4122, updated on 11-May-2012
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    Summary

    Official Symbol
    MAN2A2provided by HGNC
    Official Full Name
    mannosidase, alpha, class 2A, member 2provided by HGNC
    Primary source
    HGNC:6825
    See related
    Ensembl:ENSG00000196547; HPRD:02994; MIM:600988; Vega:OTTHUMG00000172385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MANA2X
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    Genomic context

    Location :
    15q26.1
    Sequence :
    Chromosome: 15; NC_000015.9 (91447420..91465815)
    See MAN2A2 in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene furin (paired basic amino acid cleaving enzyme) Neighboring gene feline sarcoma oncogene Neighboring gene unc-45 homolog A (C. elegans) Neighboring gene HD domain containing 3 Neighboring gene uncharacterized LOC100288997 Neighboring gene RCC1 domain containing 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. Lesch KP, et al. J Neural Transm, 2008 Nov. PMID 18839057.
    2. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.
    3. An unappreciated role for RNA surveillance. Hillman RT, et al. Genome Biol, 2004. PMID 14759258.
    4. Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin. Hart ML, et al. J Gen Virol, 2003 Feb. PMID 12560567.
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.

    See all (22) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Specific alterations of the N-linked carbohydrates on HIV-1 gp120 and gp41 by glucosidases and mannosidase inhibitors can enhance mannose-binding lectin (MBL)-mediated neutralization of virus by strengthening the interaction of HIV-1 with MBL PubMed
    env HIV-1 gp120 N-linked oligosaccharides are processed by manosidase I and II in the Golgi complex PubMed
    Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed
    Envelope transmembrane glycoprotein gp41 env Mannose-containing, N-linked oligosaccharide side-chains of HIV-1 gp41 are involved in the initial stage of infection by HIV-1; glycosylation inhibitors block virus-cell and cell-cell fusion and release of the virions PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P49641 Q12873 CHD3    HPRD  PubMed  
    P49641 Q9Y2X7 GIT1    HPRD  PubMed  
    P49641 O95163 IKBKAP    HPRD  PubMed  
    P49641 Q9Y383 LUC7L2    HPRD  PubMed  
    P49641 P08670 VIM    HPRD  PubMed  
    BioGRID:110295 BioGRID:107532 CHD3    BioGRID  PubMed Two-hybrid 
    BioGRID:110295 BioGRID:118789 GIT1    BioGRID  PubMed Two-hybrid 
    BioGRID:110295 BioGRID:114090 IKBKAP    BioGRID  PubMed Two-hybrid 
    BioGRID:110295 BioGRID:119646 LUC7L2    BioGRID  PubMed Two-hybrid 
    BioGRID:110295 BioGRID:113272 VIM    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity NAS
    Non-traceable Author Statement
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    carbohydrate metabolic process NAS
    Non-traceable Author Statement
    more info
    		  
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
    		  
    mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    post-translational protein modification TAS
    Traceable Author Statement
    more info
    		  
    protein N-linked glycosylation via asparagine TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Golgi membrane NAS
    Non-traceable Author Statement
    more info
    		  
    Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    alpha-mannosidase 2x
    Names
    alpha-mannosidase 2x
    MAN IIx
    alpha-mannosidase IIx
    mannosidase, alpha type II-X
    manosidase, alpha-, type II, isozyme X
    mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
    NP_006113.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006122.2 → NP_006113.2  alpha-mannosidase 2x

      Status: VALIDATED

      Source sequence(s)
      AC068831, AF116691, AI361497, AI697595, AL832306, CA442098, L28821
      Consensus CDS
      CCDS32332.1
      UniProtKB/Swiss-Prot
      P49641
      UniProtKB/TrEMBL
      Q9P1E4
      Related
      ENSP00000353655, ENST00000360468
      Conserved Domains (3) summary
      PLN02701
      Location:136 – 1149
      Blast Score: 2569
      PLN02701; alpha-mannosidase
      cl08536
      Location:503 – 588
      Blast Score: 273
      Alpha-mann_mid; Alpha mannosidase, middle domain
      cd11667
      Location:165 – 508
      Blast Score: 1940
      GH38N_Man2A2; N-terminal catalytic domain of Golgi alpha-mannosidase IIx, and similar proteins; glycoside hydrolase family 38 (GH38)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p5 Primary Assembly

      Range
      91447420..91465815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      67558929..67577322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC067986.24 (6469..18255) None
    genomic AC068831.17 (10583..10608) None
    genomic CH471101.1 EAX02118.1
      EAX02119.1
      EAX02120.1
      EAX02121.1
      EAX02122.1
      EAX02123.1
      EAX02124.1
    mRNA AF116691.1 AAF71111.1
    mRNA AI361497.1 None
    mRNA AI697595.1 None
    mRNA AK289863.1 BAF82552.1
    mRNA AK293799.1 BAG57210.1
    mRNA AK295646.1 BAG58516.1
    mRNA AK299213.1 BAG61252.1
    mRNA AK308838.1 None
    mRNA AK316150.1 BAH14521.1
    mRNA AL110288.1 None
    mRNA AL832306.1 None
    mRNA BC136448.1 AAI36449.1
    mRNA BC144111.1 None
    mRNA CA442098.1 None
    mRNA D55649.1 BAA09510.1
    mRNA L28821.1 AAA92022.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49641.3 GenPept UniProtKB/Swiss-Prot:P49641
    Q9P1E4 GenPept UniProtKB/TrEMBL:Q9P1E4
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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