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    Kap-alpha3 karyopherin alpha3 [ Drosophila melanogaster ]

    Gene ID: 41158, updated on 10-May-2012
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    Summary

    Official Symbol
    Kap-alpha3provided by Flybase
    Official Full Name
    karyopherin alpha3provided by Flybase
    Primary source
    FLYBASE:FBgn0027338
    Locus tag
    Dmel_CG9423
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0335/13; CG9423; Dalpha3; dKap-alpha3; Dmel\CG9423; Imp alpha-3; imp alpha3; imp-a3; imp-alpha3; IMPalpha3; Kap alpha3; Kap-?3; KAP-ALPHA3; Kpna3; l(3)S033513
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    Genomic context

    Location :
    85D25-85D25
    Sequence :
    Chromosome: 3R; NT_033777.2 (5400206..5403506, complement)
    See Kap-alpha3 in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene CG9396 gene product from transcript CG9396-RA Neighboring gene CG9399 gene product from transcript CG9399-RC Neighboring gene CG8273 gene product from transcript CG8273-RA Neighboring gene CG8301 gene product from transcript CG8301-RA Neighboring gene CG33654 gene product from transcript CG33654-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1. Chan WM, et al. Hum Mol Genet, 2011 May 1. PMID 21300695.
    3. A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint. Kondo S, et al. Sci Signal, 2011 Jan 4. PMID 21205937.
    4. Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal. Seong KH, et al. PLoS One, 2010 Dec 15. PMID 21179535.
    5. The nuclear import of Frizzled2-C by Importins-beta11 and alpha2 promotes postsynaptic development. Mosca TJ, et al. Nat Neurosci, 2010 Aug. PMID 20601947.

    See all (39) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data show that Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling.
      Title: Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling.
    2. each Imp-alpha protein carries during Drosophila spermatogenesis distinct, albeit overlapping, functions that may involve nuclear import of proteins, microtubule organisation, and other yet unknown processes
      Title: Patterns of importin-alpha expression during Drosophila spermatogenesis.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:66317 BioGRID:67770 Aats-glupro    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:71866 Atpalpha    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:67962 CG10425    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:63998 CG11586    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:64295 CG12262    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:60665 CG12264    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:64044 CG13712    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:61370 CG1416    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:58177 CG1444    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:66525 CG14712    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:58851 CG15646    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:59736 CG17259    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:61582 CG2064    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:66987 CG31291    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:64759 CG32105    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:77765 CG33303    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:65149 CG4169    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:62714 CG6370    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:61052 CG6453    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:58293 CG7033    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:62004 CG7745    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:61722 CG8258    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:59980 CG8965    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:67074 Cctgamma    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:58885 Chc    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:69179 Cnx99A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:73191 Cyp12d1-p    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:72866 Dsp1    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:69061 EfTuM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:58239 Es2    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:68906 Fatp    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:63631 Gale    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:68235 Gp93    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:65800 Karybeta3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:60023 Kr-h2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:60730 MRP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:59210 Mec2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:64920 Mpcp    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:58304 Ost48    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:66662 Past1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:60430 Pen    BioGRID  PubMed Affinity Capture-MS; Phenotypic Suppression 
    BioGRID:66317 BioGRID:77789 Pp2A-29B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:66500 Ranbp9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:67679 Rassf    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:63945 Sc2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:60062 Sec61alpha    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:58500 Sk1    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:68766 Sucb    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:66226 Tcp-1eta    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:58868 Tcp-1zeta    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:57879 Tip60    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:58951 Traf-like    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:59099 Vps4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:63159 ari-2    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:59137 betaCop    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:68605 ci    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:67688 cnc    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:59988 dsf    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:62282 fl(2)d    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:59242 l(1)G0156    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66317 BioGRID:68659 toy    BioGRID  PubMed Two-hybrid 
    BioGRID:66317 BioGRID:62039 wal    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Homology

    • Homologs of the Kap-alpha3 gene: The Kap-alpha3 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, and C.elegans.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein transmembrane transporter activity NAS
    Non-traceable Author Statement
    more info
    		  
    protein transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    mitotic cell cycle G2/M transition DNA damage checkpoint IGI
    Inferred from Genetic Interaction
    more info
    		  
    positive regulation of NFAT protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein import into nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein import into nucleus NAS
    Non-traceable Author Statement
    more info
    		  
    response to UV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear pore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nuclear pore NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CG9423 gene product from transcript CG9423-RC
    Names
    CG9423-PA
    CG9423-PB
    CG9423-PC
    CG9423-PD
    Importin-alpha3
    Kap-alpha3-PA
    Kap-alpha3-PB
    Kap-alpha3-PC
    Kap-alpha3-PD
    importin a3
    importin alpha
    importin alpha-3
    importin alpha3
    karyopherin a3
    karyopherin alpha3
    karyopherin alpha4
    karyopherin-alpha3
    karyopherin-alpha4
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      5400206..5403506, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176437.1 → NP_788614.1  karyopherin alpha3, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V455
      Related
      FBpp0081586, FBtr0082108
      Conserved Domains (3) summary
      cd00020
      Location:236 – 350
      Blast Score: 251
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      COG5064
      Location:8 – 500
      Blast Score: 1197
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      pfam01749
      Location:8 – 64
      Blast Score: 220
      IBB; Importin beta binding domain

    2. NM_169296.2 → NP_731378.1  karyopherin alpha3, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V455
      Related
      FBpp0081585, FBtr0082107
      Conserved Domains (3) summary
      cd00020
      Location:236 – 350
      Blast Score: 251
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      COG5064
      Location:8 – 500
      Blast Score: 1197
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      pfam01749
      Location:8 – 64
      Blast Score: 220
      IBB; Importin beta binding domain

    3. NM_169295.2 → NP_731377.1  karyopherin alpha3, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V455
      Related
      FBpp0081584, FBtr0082106
      Conserved Domains (3) summary
      cd00020
      Location:236 – 350
      Blast Score: 251
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      COG5064
      Location:8 – 500
      Blast Score: 1197
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      pfam01749
      Location:8 – 64
      Blast Score: 220
      IBB; Importin beta binding domain

    4. NM_001170101.1 → NP_001163572.1  karyopherin alpha3, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V455
      Related
      FBpp0290407, FBtr0301189
      Conserved Domains (3) summary
      cd00020
      Location:236 – 350
      Blast Score: 251
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      COG5064
      Location:8 – 500
      Blast Score: 1197
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      pfam01749
      Location:8 – 64
      Blast Score: 220
      IBB; Importin beta binding domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA AF152928.1 AAD37442.1
    genomic AE014297.2 ACZ94869.1
    genomic AE014297.2 AAF54408.1
    genomic AE014297.2 AAO41526.1
    mRNA AY069430.1 AAL39575.1
    genomic AE014297.2 AAN13435.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V455.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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