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    MAGEA11 melanoma antigen family A, 11 [ Homo sapiens (human) ]

    Gene ID: 4110, updated on 5-May-2013
    Official Symbol
    MAGEA11provided by HGNC
    Official Full Name
    melanoma antigen family A, 11provided by HGNC
    Primary source
    HGNC:6798
    See related
    Ensembl:ENSG00000185247; HPRD:02281; MIM:300344; Vega:OTTHUMG00000022633
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT1.11; MAGE11; MAGE-11; MAGEA-11
    Summary
    This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Location :
    Xq28
    Sequence :
    Chromosome: X; NC_000023.10 (148769903..148798928)
    See MAGEA11 in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 185A Neighboring gene melanoma antigen family A, 11 pseudogene Neighboring gene melanoma antigen family A, 10 pseudogene Neighboring gene melanoma antigen family A, 11 pseudogene

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Melanoma antigen-A11 (MAGE-A11) enhances transcriptional activity by linking androgen receptor dimers. Minges JT, et al. J Biol Chem, 2013 Jan 18. PMID 23172223.
    2. Primate-specific melanoma antigen-A11 regulates isoform-specific human progesterone receptor-B transactivation. Su S, et al. J Biol Chem, 2012 Oct 5. PMID 22891251.
    3. Androgen receptor exon 1 mutation causes androgen insensitivity by creating phosphorylation site and inhibiting melanoma antigen-A11 activation of NH2- and carboxyl-terminal interaction-dependent transactivation. Lagarde WH, et al. J Biol Chem, 2012 Mar 30. PMID 22334658.
    4. Gain in transcriptional activity by primate-specific coevolution of melanoma antigen-A11 and its interaction site in androgen receptor. Liu Q, et al. J Biol Chem, 2011 Aug 26. PMID 21730049.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (22) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. MAGE-A11 increases AR transcriptional activity by linking androgen receptor dimers.
      Title: Melanoma antigen-A11 (MAGE-A11) enhances transcriptional activity by linking androgen receptor dimers.
    2. the functional defect associated with an AR exon 1 missense mutation.
      Title: Androgen receptor exon 1 mutation causes androgen insensitivity by creating phosphorylation site and inhibiting melanoma antigen-A11 activation of NH2- and carboxyl-terminal interaction-dependent transactivation.
    3. Gain in transcriptional activity by primate-specific coevolution of melanoma antigen-A11 and its interaction site in androgen receptor.
      Title: Gain in transcriptional activity by primate-specific coevolution of melanoma antigen-A11 and its interaction site in androgen receptor.
    4. MAGE-11 links NH(2)-terminal domains of AR and p300 to promote transcriptional synergy through a cadre of FXXLF-related interacting motifs
      Title: Transcriptional synergy between melanoma antigen gene protein-A11 (MAGE-11) and p300 in androgen receptor signaling.
    5. Results suggest that MAGE-11 functions as a bridging factor to recruit androgen receptor coactivators through a novel FXX(L/I)F motif-F-box interaction paradigm.
      Title: Melanoma antigen gene protein-A11 (MAGE-11) F-box links the androgen receptor NH2-terminal transactivation domain to p160 coactivators.
    6. Increased expression of the AR coregulator MAGE-11 through promoter DNA hypomethylation and cyclic AMP is associated with prostate cancer
      Title: Increased expression of androgen receptor coregulator MAGE-11 in prostate cancer by DNA hypomethylation and cyclic AMP.
    7. Knockdown of MAGE-11 by small interfering RNA results in decreased hypoxic induction of HIF-1alpha and its target genes. Inhibition of PHD by MAGE-11, and following activation of HIFs, is a novel tumor-associated HIF regulatory mechanism.
      Title: Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response.
    8. The results suggest that MAGE-11 functions as a coregulator that increases AR transcriptional activity during the establishment of uterine receptivity in the human female.
      Title: Hormone control and expression of androgen receptor coregulator MAGE-11 in human endometrium during the window of receptivity to embryo implantation.
    9. The time-dependent EGF-induced increase in AR transcriptional activity by MAGE-11 is mediated through AR activation functions 1 and 2 in association with the increased turnover of AR and MAGE-11.
      Title: Epidermal-growth-factor-dependent phosphorylation and ubiquitinylation of MAGE-11 regulates its interaction with the androgen receptor.
    10. MAGE-11 is a unique AR coregulator that increases AR activity by modulating the AR interdomain interaction.
      Title: Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    P43364 Q8TDX5 ACMSD    HPRD  PubMed  
    P43364 P12814 ACTN1    HPRD  PubMed  
    P43364 P42330 AKR1C3    HPRD  PubMed  
    P43364 PARG1 ARHGAP29    HPRD  PubMed  
    P43364 Q9BXY8 BEX2    HPRD  PubMed  
    P43364 Q13489 BIRC3    HPRD  PubMed  
    P43364 Q8IYD9 C18orf54    HPRD  PubMed  
    P43364 Q8N715 C1orf65    HPRD  PubMed  
    P43364 Coiled-coil domain containing 14 CCDC14    HPRD  PubMed  
    P43364 P42772 CDKN2B    HPRD  PubMed  
    P43364 Q8TAP6 CEP76    HPRD  PubMed  
    P43364 Q96AJ1 CLUAP1    HPRD  PubMed  
    P43364 O14548 COX7A2L    HPRD  PubMed  
    P43364 Q68CQ4 DIEXF    HPRD  PubMed  
    P43364 ERDJ5 DNAJC10    HPRD  PubMed  
    P43364 Q16206 ENOX2    HPRD  PubMed  
    P43364 Q01844 EWSR1    HPRD  PubMed  
    P43364 Q8NDB6 FAM156A    HPRD  PubMed  
    P43364 P20809 IL11    HPRD  PubMed  
    P43364 Q12906 ILF3    HPRD  PubMed  
    P43364 Q6ZU52 KIAA0408    HPRD  PubMed  
    P43364 Q8TBB1 LNX1    HPRD  PubMed  
    P43364 Q96EZ8 MCRS1    HPRD  PubMed  
    P43364 Q9H204 MED28    HPRD  PubMed  
    P43364 Q9BQP7 MGME1    HPRD  PubMed  
    P43364 P58340 MLF1    HPRD  PubMed  
    P43364 Q9BW11 MXD3    HPRD  PubMed  
    P43364 Q9NP98 MYOZ1    HPRD  PubMed  
    P43364 Q9GZM8 NDEL1    HPRD  PubMed  
    P43364 Q9Y375 NDUFAF1    HPRD  PubMed  
    P43364 Q9Y6M9 NDUFB9    HPRD  PubMed  
    P43364 Q9GZT8 NIF3L1    HPRD  PubMed  
    P43364 O94818 NOL4    HPRD  PubMed  
    P43364 NSUN4 NSUN4    HPRD  PubMed  
    P43364 Q96DC9 OTUB2    HPRD  PubMed  
    P43364 O14832 PHYH    HPRD  PubMed  
    P43364 Q8N490 PNKD    HPRD  PubMed  
    P43364 Q96T60 PNKP    HPRD  PubMed  
    P43364 Q9Y2S0 POLR1D    HPRD  PubMed  
    P43364 P30048 PRDX3    HPRD  PubMed  
    P43364 PRKR interacting protein 1 PRKRIP1    HPRD  PubMed  
    P43364 Q92530 PSMF1    HPRD  PubMed  
    P43364 Hypothetical protein FLJ10324 RADIL    HPRD  PubMed  
    P43364 Q9H788 SH2D4A    HPRD  PubMed  
    P43364 Selectin ligand interactor cytoplasmic1 SNX20    HPRD  PubMed  
    P43364 Q9UNH6 SNX7    HPRD  PubMed  
    P43364 Q15560 TCEA2    HPRD  PubMed  
    P43364 Q9BQ70 TCF25    HPRD  PubMed  
    P43364 Chromosome 2 open reading frame 51 TEX37    HPRD  PubMed  
    P43364 Pro-oncosis receptor inducing membrane injury gene TMEM123    HPRD  PubMed  
    P43364 P14373 TRIM27    HPRD  PubMed  
    P43364 TRIM51 TRIM51    HPRD  PubMed  
    P43364 Q9NXH9 TRMT1    HPRD  PubMed  
    P43364 Q9Y2X8 UBE2D4    HPRD  PubMed  
    P43364 Q9NP79 VTA1    HPRD  PubMed  
    P43364 Q15007 WTAP    HPRD  PubMed  
    P43364 Q05516 ZBTB16    HPRD  PubMed  
    P43364 Q8N720 ZNF655    HPRD  PubMed  
    P43364 Q8NEG5 ZSWIM2    HPRD  PubMed  
    BioGRID:110284 BioGRID:126217 ACMSD    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:106602 ACTN1    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:114196 AKR1C3    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:110284 BioGRID:114806 ARHGAP29    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:198179 Ar    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110284 BioGRID:124218 BEX2    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:106826 BIRC2    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:127828 C18orf54    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:127889 C1orf65    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:122281 CCDC14    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:107464 CDKN2B    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:123028 CEP76    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:116694 CLUAP1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110284 BioGRID:114608 COX7A2L    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:117972 DIEXF    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:119947 DNAJC10    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:120060 EGLN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110284 BioGRID:125184 EGLN2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110284 BioGRID:125185 EGLN3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110284 BioGRID:115758 ENOX2    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110284 BioGRID:108431 EWSR1    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:118833 FAM156A    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:108579 FKBP5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110284 BioGRID:109803 IL11    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:109822 ILF3    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:115078 KIAA0408    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:124219 LNX1    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:110284 MAGEA11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110284 BioGRID:111581 MAPK3    BioGRID  PubMed Biochemical Activity 
    BioGRID:110284 BioGRID:115710 MCRS1    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:123219 MED28    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:124964 MGME1    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:110437 MLF1    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:123658 MXD3    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:121849 MYOZ1    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:115761 NCOA2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110284 BioGRID:123527 NDEL1    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:119292 NDUFAF1    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:110795 NDUFB9    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:121922 NIF3L1    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:114256 NOL4    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:109165 NR3C1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110284 BioGRID:132288 NSUN4    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:122461 OTUB2    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:111260 PGR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110284 BioGRID:111282 PHYH    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:117446 PNKD    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:116440 PNKP    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:119272 POLR1D    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:116136 PRDX3    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:122824 PRKRIP1    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:114872 PSMF1    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:120823 RADIL    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:121977 SH2D4A    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110284 BioGRID:112391 SKP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110284 BioGRID:125867 SNX20    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:119508 SNX7    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:112781 TCEA2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110284 BioGRID:127996 TCEANC    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:116629 TCF25    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:128332 TEX37    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:125396 TMEM123    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:111919 TRIM27    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:124248 TRIM51    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:120760 TRMT1    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110284 BioGRID:119641 UBE2D4    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:119595 VTA1    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:114957 WTAP    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:113498 ZBTB16    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:122495 ZNF655    BioGRID  PubMed Two-hybrid 
    BioGRID:110284 BioGRID:127342 ZSWIM2    BioGRID  PubMed Two-hybrid 

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC10511

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    Preferred Names
    melanoma-associated antigen 11
    Names
    melanoma-associated antigen 11
    MAGE-11 antigen
    cancer/testis antigen 1.11
    cancer/testis antigen family 1, member 11

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012803.1 RefSeqGene

      Range
      5001..34026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001011544.1 → NP_001011544.1  melanoma-associated antigen 11 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and CDS compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AI691089, BC004479, BX337921
      UniProtKB/TrEMBL
      G5E962
      UniProtKB/Swiss-Prot
      P43364
      Related
      ENSP00000328177, ENST00000333104
      Conserved Domains (2) summary
      pfam12440
      Location:84 – 179
      Blast Score: 158
      MAGE_N; Melanoma associated antigen family N terminal
      pfam01454
      Location:200 – 370
      Blast Score: 737
      MAGE; MAGE family

    2. NM_005366.4 → NP_005357.2  melanoma-associated antigen 11 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AI691089, BC004479, BQ212898
      Consensus CDS
      CCDS48180.1
      UniProtKB/Swiss-Prot
      P43364
      Related
      ENSP00000347358, OTTHUMP00000024217, ENST00000355220, OTTHUMT00000058725
      Conserved Domains (2) summary
      pfam12440
      Location:113 – 208
      Blast Score: 156
      MAGE_N; Melanoma associated antigen family N terminal
      pfam01454
      Location:229 – 399
      Blast Score: 739
      MAGE; MAGE family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 PATCHES

    Genomic

    1. NW_004070890.1 Reference GRCh37.p10 PATCHES

      Range
      5212635..5241666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p10 Primary Assembly

      Range
      148769903..148798928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000155.1 Alternate HuRef

      Range
      137720552..137749560, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018934.1 Alternate CHM1_1.0

      Range
      148723345..148752458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01027296.1 None
    genomic ABBA01027297.1 None
    genomic ABBA01027298.1 None
    genomic ABBA01027299.1 None
    genomic ABBA01027300.1 None
    genomic AC016939.8 (2001..3647) None
    genomic AC139014.14 None
    genomic AC231844.2 (155914..160424) None
    genomic AC232272.2 (36736..61250) None
    genomic AC244098.2 (126278..148967) None
    genomic AC244197.3 (208921..215262) None
    genomic AMYH01023193.1 (350977..374680) None
    genomic AMYH01023194.1 None
    genomic CH471169.1 EAW99364.1
      EAW99365.1
      EAW99366.1
    genomic U10686.1 AAA68870.1
    mRNA AI691089.1 None
    mRNA AK127849.1 BAC87161.1
    mRNA AY747607.1 AAW71787.1
    mRNA BC004479.2 AAH04479.2
    mRNA BQ212898.1 None
    mRNA BX337921.2 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43364.2 GenPept UniProtKB/Swiss-Prot:P43364

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • SNP: VarView
        Related Clinical SNP
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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