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    neur neuralized [ Drosophila melanogaster ]

    Gene ID: 41085, updated on 10-May-2012
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    Summary

    Official Symbol
    neurprovided by Flybase
    Official Full Name
    neuralizedprovided by Flybase
    Primary source
    FLYBASE:FBgn0002932
    Locus tag
    Dmel_CG11988
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0328/12; 0971/15; 1293/09; 1315/05; BEST:LD21494; CG11988; Dmel\CG11988; l(3)j6B12; l(3)j9B8; l(3)j9B9; l(3)j9C8; l(3)neo37; neu; Neur
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    Genomic context

    Location :
    85C2-85C3; 3-48.5 cM
    Sequence :
    Chromosome: 3R; NT_033777.2 (4846068..4865189, complement)
    See neur in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene CG11985 gene product from transcript CG11985-RA Neighboring gene CG11986 gene product from transcript CG11986-RA Neighboring gene tango Neighboring gene ncRNA Neighboring gene hyrax Neighboring gene NAD-dependent methylenetetrahydrofolate dehydrogenase Neighboring gene Relish Neighboring gene CG11993 gene product from transcript CG11993-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Distinct intracellular motifs of Delta mediate its ubiquitylation and activation by Mindbomb1 and Neuralized. Daskalaki A, et al. J Cell Biol, 2011 Dec 12. PMID 22162135.
    2. Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. Weake VM, et al. Genes Dev, 2011 Jul 15. PMID 21764853.
    3. Sexually dimorphic shaping of interneuron dendrites involves the hunchback transcription factor. Goto J, et al. J Neurosci, 2011 Apr 6. PMID 21471381.
    4. Ral GTPase promotes asymmetric Notch activation in the Drosophila eye in response to Frizzled/PCP signaling by repressing ligand-independent receptor activation. Cho B, et al. Development, 2011 Apr. PMID 21350007.
    5. Apoptosis ensures spacing pattern formation of Drosophila sensory organs. Koto A, et al. Curr Biol, 2011 Feb 22. PMID 21276725.

    See all (247) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The ubiquitylation of Delta by both Neuralized and Mindbomb1 was detected, with the two enzymes using distinct docking sites and having different acceptor lysine preferences.
      Title: Distinct intracellular motifs of Delta mediate its ubiquitylation and activation by Mindbomb1 and Neuralized.
    2. results tie Numb and Notch-signaling through a single player, Neur, thus giving us a more complete picture of the events surrounding asymmetric division of precursor cells
      Title: Neuralized mediates asymmetric division of neural precursors by two distinct and sequential events: promoting asymmetric localization of Numb and enhancing activation of Notch-signaling.
    3. inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta
      Title: Both inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta.
    4. the highly conserved ubiquitin ligase Neuralized (Neur) is expressed in the adult Drosophila mushroom body (MB) alpha/beta lobe peripheral neurons and is a limiting factor for the formation of long-term memory
      Title: Neuralized is expressed in the alpha/beta lobes of adult Drosophila mushroom bodies and facilitates olfactory long-term memory formation.
    5. The diverse phenotypic effects arising from nearby P-element insertions in neur provide a new appreciation of the concept of allelic effects on phenotype.
      Title: Pleiotropic effects of Drosophila neuralized on complex behaviors and brain structure.
    6. The neuralized homology repeat 1 domain of Drosophila neuralized mediates nuclear envelope association and delta-dependent inhibition of nuclear import.
      Title: The neuralized homology repeat 1 domain of Drosophila neuralized mediates nuclear envelope association and delta-dependent inhibition of nuclear import.
    7. D-mib and Neur are two structurally distinct proteins that have similar molecular activities but distinct developmental functions in Drosophila.
      Title: Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila.
    8. DSL internalization and signaling are promoted in Drosophila by the ubiquitin ligases Mind bomb (Mib) and Neuralized (Neur)
      Title: Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila.
    9. inhibition of Neur by Brd proteins is important for precise spatial regulation of Dl signaling
      Title: Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila.
    10. E3 ubiquitin ligase neuralized is required for both Delta endocytosis and the internalization of Sanpodo
      Title: Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs.
    Submit: New GeneRIF Correction See all (13)
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:66253 BioGRID:64945 Brd    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:66253 BioGRID:72650 CG34401    BioGRID  PubMed Two-hybrid 
    BioGRID:66253 BioGRID:67310 Dl    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement 
    BioGRID:66253 BioGRID:62075 Drep-3    BioGRID  PubMed Two-hybrid 
    BioGRID:66253 BioGRID:67421 H    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:66253 BioGRID:61271 La    BioGRID  PubMed Two-hybrid 
    BioGRID:66253 BioGRID:57823 N    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:66253 BioGRID:64944 Tom    BioGRID  PubMed Two-hybrid 
    BioGRID:66253 BioGRID:66859 eff    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:66253 BioGRID:61489 koi    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the neur gene: The neur gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, mosquito, and C.elegans.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    asymmetric cell division TAS
    Traceable Author Statement
    more info
    		 PubMed 
    brain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    compound eye development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    ectoderm development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    germ-line stem cell maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    inter-male aggressive behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    lateral inhibition IMP
    Inferred from Mutant Phenotype
    more info
    		  
    locomotion involved in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    nervous system development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    ovarian follicle cell development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    peripheral nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of Notch signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of compound eye photoreceptor development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of photoreceptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    sensory organ precursor cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    startle response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG11988 gene product from transcript CG11988-RD
    Names
    CG11988-PA
    CG11988-PB
    CG11988-PC
    CG11988-PD
    CG11988-PE
    neur-PA
    neur-PB
    neur-PC
    neur-PD
    neur-PE
    neuralised
    neuralized
    NP_001163563.1
    NP_476652.1
    NP_731309.1
    NP_731310.1
    NP_731311.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      4846068..4865189, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169255.1 → NP_731309.1  neuralized, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29503
      Related
      FBpp0081480, FBtr0082002
      Conserved Domains (3) summary
      cd00162
      Location:617 – 662
      Blast Score: 119
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl02685
      Location:24 – 143
      Blast Score: 462
      Neuralized; Neuralized
      pfam13923
      Location:617 – 660
      Blast Score: 120
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    2. NM_169256.1 → NP_731310.1  neuralized, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIG1
      UniProtKB/Swiss-Prot
      P29503
      Related
      FBpp0081479, FBtr0082001
      Conserved Domains (3) summary
      cd00162
      Location:618 – 663
      Blast Score: 119
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl02685
      Location:24 – 143
      Blast Score: 462
      Neuralized; Neuralized
      pfam13923
      Location:618 – 661
      Blast Score: 120
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    3. NM_169257.1 → NP_731311.1  neuralized, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29503
      Related
      FBpp0081482, FBtr0082004
      Conserved Domains (3) summary
      cd00162
      Location:699 – 744
      Blast Score: 120
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl02685
      Location:106 – 225
      Blast Score: 463
      Neuralized; Neuralized
      pfam13923
      Location:699 – 742
      Blast Score: 121
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    4. NM_057304.3 → NP_476652.1  neuralized, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P29503
      Related
      FBpp0081481, FBtr0082003
      Conserved Domains (3) summary
      cd00162
      Location:700 – 745
      Blast Score: 120
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl02685
      Location:106 – 225
      Blast Score: 463
      Neuralized; Neuralized
      pfam13923
      Location:700 – 743
      Blast Score: 122
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    5. NM_001170092.1 → NP_001163563.1  neuralized, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIG1
      UniProtKB/Swiss-Prot
      P29503
      Related
      FBpp0289643, FBtr0300414
      Conserved Domains (3) summary
      cd00162
      Location:618 – 663
      Blast Score: 119
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl02685
      Location:24 – 143
      Blast Score: 462
      Neuralized; Neuralized
      pfam13923
      Location:618 – 661
      Blast Score: 120
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014297.2 AAN13406.1
    genomic AE014297.2 ACZ94860.1
    genomic AE014297.2 AAN13407.1
    mRNA BT003772.1 AAO41451.1
    genomic AE014297.2 AAF54326.2
    mRNA AY051987.1 AAK93411.1
    mRNA L12218.1 AAA28403.1
    genomic AE014297.2 AAF54330.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    S35503.1 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content