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    SMAD7 SMAD family member 7 [ Homo sapiens ]

    Gene ID: 4092, updated on 19-May-2012
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    Summary

    Official Symbol
    SMAD7provided by HGNC
    Official Full Name
    SMAD family member 7provided by HGNC
    Primary source
    HGNC:6773
    See related
    Ensembl:ENSG00000101665; HPRD:04241; MIM:602932; Vega:OTTHUMG00000132655
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRCS3; MADH7; MADH8; FLJ16482
    Summary
    The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
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    Genomic context

    Location :
    18q21.1
    Sequence :
    Chromosome: 18; NC_000018.9 (46446223..46477081, complement)
    See SMAD7 in Epigenomics, MapViewer

    Chromosome 18 - NC_000018.9Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) III (DNA directed) polypeptide G (32kD) pseudogene Neighboring gene CBP80/20-dependent translation initiation factor Neighboring gene microRNA 4743 Neighboring gene uncharacterized LOC100652797 Neighboring gene microRNA 4744 Neighboring gene dymeclin

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Substratum topography modulates corneal fibroblast to myofibroblast transformation. Myrna KE, et al. Invest Ophthalmol Vis Sci, 2012. PMID 22232431.
    2. Differential effect of the expression of TGF-β pathway inhibitors, Smad-7 and Ski, on invasive breast carcinomas: relation to biologic behavior. Theohari I, et al. APMIS, 2012 Feb. PMID 22229264.
    3. Smad7 acts as a negative regulator of the epidermal growth factor (EGF) signaling pathway in breast cancer cells. Kim S, et al. Cancer Lett, 2012 Jan 28. PMID 22033246.
    4. Smad7 expression in T cells prevents colitis-associated cancer. Rizzo A, et al. Cancer Res, 2011 Dec 15. PMID 22028324.
    5. The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor β (TGF-β) signaling and the development of regulatory T cells. Zhao Y, et al. J Biol Chem, 2011 Nov 25. PMID 21931165.

    See all (169) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. nanoscale topographic features modulate TGFbeta-induced myofibroblast differentiation and alphaSMA expression, possibly through upregulation of Smad7.
      Title: Substratum topography modulates corneal fibroblast to myofibroblast transformation.
    2. Smad-7 expression in breast neoplasms in positively correlated with tumor size, stage, and lymph node status.
      Title: Differential effect of the expression of TGF-β pathway inhibitors, Smad-7 and Ski, on invasive breast carcinomas: relation to biologic behavior.
    3. Results show SMAD7 variants known to be important for CRC risk were associated with disease-specific survival among prediagnostic NSAID users.
      Title: Common colorectal cancer risk variants in SMAD7 are associated with survival among prediagnostic nonsteroidal anti-inflammatory drug users: a population-based study of postmenopausal women.
    4. Data show that Smad7 is downregulated in inflamed colon of patients with inflammatory bowel disease (IBD)-related colitis-associated colorectal cancer (CAC).
      Title: Smad7 expression in T cells prevents colitis-associated cancer.
    5. These outcomes suggest that rs12953717 is a common risk marker of colorectal, gastric, and lung cancers in the Han Chinese.
      Title: A risk-associated single nucleotide polymorphism of SMAD7 is common to colorectal, gastric, and lung cancers in a Han Chinese population.
    6. SMAD7 rs4464148 variant genotype was associated with increased cancer incidence
      Title: SMAD7 and MGMT genotype variants and cancer incidence in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk Study.
    7. CYLD regulates TGF-beta signaling function in T cells and the development of Tregs through deubiquitination of Smad7
      Title: The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor β (TGF-β) signaling and the development of regulatory T cells.
    8. smad7 inhibits TGF-beta1 as well as the EGF signaling pathway in SKBR3 cells.
      Title: Smad7 acts as a negative regulator of the epidermal growth factor (EGF) signaling pathway in breast cancer cells.
    9. Smad7 over-expression inhibits Smad2/3 phosphorylation, and decreases the expression of collagen I and alpha-SMA in HSC-T6 cells induced by TGF-beta1 to inhibit the progression of liver fibrosis.
      Title: [Smad7 inhibits collagen expression in human hepatic satellite cells in vitro].
    10. Smad7 overexpression is effective in blocking gingival myofibroblast transformation and activation.
      Title: Smad7 blocks transforming growth factor-β1-induced gingival fibroblast-myofibroblast transition via inhibitory regulation of Smad2 and connective tissue growth factor.
    Submit: New GeneRIF Correction See all (109)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.

    A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.

    Colorectal cancer, susceptibility to, 3

    Colorectal cancer, susceptiblity to

    Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-induced apoptosis in human proximal renal tubular cells is significantly enhanced by p300, and Smad7 and an anti-TGF-beta antibody inhibit this effect of p300 PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_005895.1 SMURF1    BIND  PubMed Smad7 interacts with Smurf1. This interaction was modeled on a demonstrated interaction between Smad7 and Smurf1, both from an unspecified species. 
    NP_005895.1 NP_073576.1 SMURF2    BIND  PubMed SMAD7 interacts with SMURF2. 
    O15105 P36896 ACVR1B    HPRD  PubMed  
    O15105 P31749 AKT1    HPRD  PubMed  
    O15105 Q9NR48 ASH1L    HPRD  PubMed  
    O15105 O15169 AXIN1    HPRD  PubMed  
    O15105 O00238 BMPR1B    HPRD  PubMed  
    O15105 P35222 CTNNB1    HPRD  PubMed  
    O15105 CXXC finger 5 CXXC5    HPRD  PubMed  
    O15105 O14640 DVL1    HPRD  PubMed  
    O15105 Q09472 EP300    HPRD  PubMed  
    O15105 Q96RT1 ERBB2IP    HPRD  PubMed  
    O15105 O14929 HAT1    HPRD  PubMed  
    O15105 Hairy/enhancer-of-split related with YRPW motif-like HEYL    HPRD  PubMed  
    O15105 Q9Y2K7 KDM2A    HPRD  PubMed  
    O15105 P46734 MAP2K3    HPRD  PubMed  
    O15105 P52564 MAP2K6    HPRD  PubMed  
    O15105 O43318 MAP3K7    HPRD  PubMed  
    O15105 Q16539 MAPK14    HPRD  PubMed  
    O15105 Q9UIS9 MBD1    HPRD  PubMed  
    O15105 P15172 MYOD1    HPRD  PubMed  
    O15105 Q8TEW0 PARD3    HPRD  PubMed  
    O15105 O75925 PIAS1    HPRD  PubMed  
    O15105 Q8N2W9 PIAS4    HPRD  PubMed  
    O15105 Q6ZNA4 RNF111    HPRD  PubMed  
    O15105 O75995 SASH3    HPRD  PubMed  
    O15105 O43541 SMAD6    HPRD  PubMed  
    O15105 O15105 SMAD7    HPRD  PubMed  
    O15105 Q9HCE7 SMURF1    HPRD  PubMed  
    O15105 Q9HAU4 SMURF2    HPRD  PubMed  
    O15105 Q9UN79 SOX13    HPRD  PubMed  
    O15105 P35711 SOX5    HPRD  PubMed  
    O15105 Q9BT81 SOX7    HPRD  PubMed  
    O15105 O95630 STAMBP    HPRD  PubMed  
    O15105 Q96FJ0 STAMBPL1    HPRD  PubMed  
    O15105 Q9Y3F4 STRAP    HPRD  PubMed  
    O15105 Q15750 TAB1    HPRD  PubMed  
    O15105 P36897 TGFBR1    HPRD  PubMed  
    O15105 P37173 TGFBR2    HPRD  PubMed  
    O15105 Q15361 TTF1    HPRD  PubMed  
    O15105 Q9UNY4 TTF2    HPRD  PubMed  
    O15105 P12956 XRCC6    HPRD  PubMed  
    O15105 P46937 YAP1    HPRD  PubMed  
    O15105 O95625 ZBTB11    HPRD  PubMed  
    O15105 Q8NCP5 ZBTB44    HPRD  PubMed  
    O15105 Q9UII5 ZNF107    HPRD  PubMed  
    BioGRID:110267 BioGRID:106606 ACVR1B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:107125 BMPR1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:110267 BioGRID:108188 DVL1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110267 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:110267 BioGRID:120997 ERBB2IP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110267 BioGRID:108570 FKBP1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110267 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:114368 HDAC3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:115330 HDAC6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:123747 ITCH    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:114375 KAT2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:119354 LEF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:111592 MAP2K3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:111594 MAP2K6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:112748 MAP3K7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:107819 MAPK14    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:110811 NEDD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:125592 PARD3B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110267 BioGRID:119624 PIAS4    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110267 BioGRID:120146 RNF111    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:116983 SIRT1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110267 BioGRID:110262 SMAD2    BioGRID  PubMed Phenotypic Suppression; Reconstituted Complex 
    BioGRID:110267 BioGRID:110263 SMAD3    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:110267 BioGRID:110264 SMAD4    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex 
    BioGRID:110267 BioGRID:110266 SMAD6    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110267 BioGRID:121411 SMURF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:122265 SMURF2    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex 
    BioGRID:110267 BioGRID:112600 SRF    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:115863 STAMBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:116342 STRAP    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement 
    BioGRID:110267 BioGRID:115717 TAB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:112904 TGFBR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110267 BioGRID:112906 TGFBR2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:114374 TSC22D1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:119509 UCHL5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110267 BioGRID:116243 WWP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110267 BioGRID:116244 WWP2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:110267 BioGRID:211793 Wwp2    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110267 BioGRID:115684 YAP1    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement; Two-hybrid 
    BioGRID:110267 BioGRID:112796 ZEB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • ALK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      ALK1 signaling events, organism-specific biosystem
      ALK1 signaling events
    • BMP receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      BMP receptor signaling, organism-specific biosystem
      BMP receptor signaling
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • IFN-gamma pathway, organism-specific biosystem (from Pathway Interaction Database)
      IFN-gamma pathway, organism-specific biosystem
      IFN-gamma pathway
    • Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
      Regulation of nuclear SMAD2/3 signaling
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by BMP, organism-specific biosystem (from REACTOME)
      Signaling by BMP, organism-specific biosystemThe TGF-beta/BMP (bone morphogenetic protein) pathway incorporates several signalling pathways that share most, but not all, components of a central signal transduction engine. The general signalling...
    • Signaling by TGF beta, organism-specific biosystem (from REACTOME)
      Signaling by TGF beta, organism-specific biosystemThe TGF-beta/BMP pathway incorporates several signalling pathways that share most, but not all, components of a central signal transduction engine. The general signalling scheme is rather simple: upo...
    • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class I, organism-specific biosystem
      Signaling events mediated by HDAC Class I
    • TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • TGF-beta receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      TGF-beta receptor signaling, organism-specific biosystem
      TGF-beta receptor signaling
    • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
      TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • TGF-beta signaling pathway, conserved biosystem (from KEGG)
      TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    I-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    activin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    collagen binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    type I transforming growth factor beta receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    BMP signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    adherens junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    artery morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cellular protein complex localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of cell migration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of epithelial to mesenchymal transition IC
    Inferred by Curator
    more info
    		 PubMed 
    negative regulation of epithelial to mesenchymal transition TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of pathway-restricted SMAD protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of pathway-restricted SMAD protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription by competitive promoter binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    pathway-restricted SMAD protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of anti-apoptosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of activin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of cardiac muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of transforming growth factor beta receptor signaling pathway IC
    Inferred by Curator
    more info
    		 PubMed 
    regulation of ventricular cardiomyocyte membrane depolarization IC
    Inferred by Curator
    more info
    		 PubMed 
    response to laminar fluid shear stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    transforming growth factor beta receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
    		  
    ventricular cardiac muscle tissue morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    ventricular septum morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with catenin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    mothers against decapentaplegic homolog 7
    Names
    mothers against decapentaplegic homolog 7
    hSMAD7
    MAD homolog 8
    mothers against DPP homolog 8
    SMAD, mothers against DPP homolog 7
    Mothers against decapentaplegic, drosophila, homolog of, 7
    MAD (mothers against decapentaplegic, Drosophila) homolog 7
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023330.1 RefSeqGene

      Range
      5001..35859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001190821.1 → NP_001177750.1  mothers against decapentaplegic homolog 7 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AC114684, AF010193, DA882147
      UniProtKB/Swiss-Prot
      O15105
      Conserved Domains (2) summary
      cd10494
      Location:89 – 207
      Blast Score: 386
      MH1_SMAD_7; N-terminal Mad Homology 1 (MH1) domain in SMAD7
      cd10500
      Location:253 – 423
      Blast Score: 945
      MH2_SMAD_7; C-terminal Mad Homology 2 (MH2) domain in SMAD7

    2. NM_001190822.1 → NP_001177751.1  mothers against decapentaplegic homolog 7 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC114684, AF010193, AK301535
      Consensus CDS
      CCDS54186.1
      UniProtKB/TrEMBL
      B7Z773
      UniProtKB/Swiss-Prot
      O15105
      Related
      ENSP00000438103, ENST00000545051
      Conserved Domains (1) summary
      cd10500
      Location:39 – 209
      Blast Score: 935
      MH2_SMAD_7; C-terminal Mad Homology 2 (MH2) domain in SMAD7

    3. NM_001190823.1 → NP_001177752.1  mothers against decapentaplegic homolog 7 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC114684, AF010193, AK301535, BP363832
      UniProtKB/TrEMBL
      B3KYA8
      UniProtKB/TrEMBL
      B7Z773
      UniProtKB/Swiss-Prot
      O15105
      Conserved Domains (1) summary
      cd10500
      Location:66 – 236
      Blast Score: 940
      MH2_SMAD_7; C-terminal Mad Homology 2 (MH2) domain in SMAD7

    4. NM_005904.3 → NP_005895.1  mothers against decapentaplegic homolog 7 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC114684, AF010193
      Consensus CDS
      CCDS11936.1
      UniProtKB/Swiss-Prot
      O15105
      Related
      ENSP00000262158, OTTHUMP00000163490, ENST00000262158, OTTHUMT00000255906
      Conserved Domains (2) summary
      cd10494
      Location:89 – 207
      Blast Score: 386
      MH1_SMAD_7; N-terminal Mad Homology 1 (MH1) domain in SMAD7
      cd10500
      Location:254 – 424
      Blast Score: 945
      MH2_SMAD_7; C-terminal Mad Homology 2 (MH2) domain in SMAD7

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000018.9 Reference GRCh37.p5 Primary Assembly

      Range
      46446223..46477081, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000150.1 Alternate HuRef

      Range
      43299249..43329936, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC114684.10 (47304..78162) None
    genomic AF026559.1 AAL68977.1
    genomic AF156731.1 None
    genomic CH471096.1 EAW62931.1
    mRNA AF010193.1 AAB81246.1
    mRNA AF015261.1 AAB81354.1
    mRNA AK131394.1 BAG54770.1
    mRNA AK301535.1 BAH13509.1
    mRNA BC074818.2 AAH74818.2
    mRNA BC074819.2 AAH74819.2
    mRNA BP363832.1 None
    mRNA DA882147.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15105.1 GenPept UniProtKB/Swiss-Prot:O15105
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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