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    alpha-Est7 alpha-Esterase-7 [ Drosophila melanogaster ]

    Gene ID: 40901, updated on 9-May-2012
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    Summary

    Official Symbol
    alpha-Est7provided by Flybase
    Official Full Name
    alpha-Esterase-7provided by Flybase
    Primary source
    FLYBASE:FBgn0015575
    Locus tag
    Dmel_CG1112
    Gene type
    protein coding
    RNA name
    alpha-Esterase-7
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aE7; ali; Ali; alphaE7; alphaest-7; CG1112; DmalphaE7; Dmel\CG1112; Est-23; Est23; EST23; H; Mce
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    Genomic context

    Location :
    84D9-84D9
    Sequence :
    Chromosome: 3R; NT_033777.2 (3345285..3349476, complement)
    See alpha-Est7 in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene alpha-Esterase-8 Neighboring gene Ubiquitin conjugating enzyme 84D Neighboring gene alpha-Esterase-6 Neighboring gene pseudo Neighboring gene CG1279 gene product from transcript CG1279-RC

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster α-Esterase-7. Birner-Gruenberger R, et al. Insect Biochem Mol Biol, 2012 Mar. PMID 22198472.
    2. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    3. Does the clock make the poison? Circadian variation in response to pesticides. Hooven LA, et al. PLoS One, 2009 Jul 31. PMID 19649249.
    4. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.
    5. The Release 5.1 annotation of Drosophila melanogaster heterochromatin. Smith CD, et al. Science, 2007 Jun 15. PMID 17569856.

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. alpha-Est7 gene is not essential for Drosophila development but serves important functions for insecticide tolerance, lipid metabolism and lifespan control.
      Title: Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster α-Esterase-7.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:66091 BioGRID:61972 CG7737    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:66091 BioGRID:66481 RpL3    BioGRID  PubMed Two-hybrid 
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    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    carboxylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    carboxylesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    carboxylesterase activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    lipid particle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG1112 gene product from transcript CG1112-RA
    Names
    CG1112-PA
    aliesterase
    aliesteraseless
    alpha-Est7-PA
    alpha-Esterase-7
    carboxylesterase 23
    esterase 23
    fragment H
    malathion carboxylesterase
    NP_524261.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      3345285..3349476, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079537.3 → NP_524261.1  alpha-Esterase-7 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIB5
      Related
      FBpp0081074
      Conserved Domains (2) summary
      pfam00135
      Location:34 – 555
      Blast Score: 1403
      COesterase; Carboxylesterase family
      cl12031
      Location:34 – 535
      Blast Score: 882
      Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA AY051473.1 AAK92897.1
    genomic AE014297.2 AAF54010.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIB5.1 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content