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    ARRB2 arrestin, beta 2 [ Homo sapiens ]

    Gene ID: 409, updated on 19-May-2012
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    Summary

    Official Symbol
    ARRB2provided by HGNC
    Official Full Name
    arrestin, beta 2provided by HGNC
    Primary source
    HGNC:712
    See related
    Ensembl:ENSG00000141480; HPRD:00147; MIM:107941; Vega:OTTHUMG00000090759
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARB2; ARR2; BARR2; DKFZp686L0365
    Summary
    Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
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    Genomic context

    Location :
    17p13
    Sequence :
    Chromosome: 17; NC_000017.10 (4613789..4624795)
    See ARRB2 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene proline, glutamate and leucine rich protein 1 Neighboring gene ribosomal protein S12 pseudogene 29 Neighboring gene mediator complex subunit 11 Neighboring gene chemokine (C-X-C motif) ligand 16 Neighboring gene zinc finger, MYND-type containing 15

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Protein phosphatase 2A interacts with the Na,K-ATPase and modulates its trafficking by inhibition of its association with arrestin. Kimura T, et al. PLoS One, 2011. PMID 22242112.
    2. β-arrestin2 plays permissive roles in the inhibitory activities of RGS9-2 on G protein-coupled receptors by maintaining RGS9-2 in the open conformation. Zheng M, et al. Mol Cell Biol, 2011 Dec. PMID 22006018.
    3. Beta-arrestin2 as a competitor for GRK2 interaction with the GLP-1 receptor upon receptor activation. Jorgensen R, et al. Pharmacology, 2011. PMID 21952200.
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.

    See all (169) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. PP2A inhibits association between the Na+,K+-ATPase and arrestin, and diminishes the effect of arrestin on Na+,K+-ATPase trafficking.
      Title: Protein phosphatase 2A interacts with the Na,K-ATPase and modulates its trafficking by inhibition of its association with arrestin.
    2. these studies demonstrate that arrestin2 levels decrease while arrestin3 levels increase during breast cancer progression and these changes correlate with a poor clinical outcome.
      Title: Differential expression of arrestins is a predictor of breast cancer progression and survival.
    3. betaarr2 competes with GRK2 for interaction with the activated and GRK phosphorylated GLP-1R, suggesting a new role of betaarr2 in regulating the orchestration of GRK2 functionality
      Title: Beta-arrestin2 as a competitor for GRK2 interaction with the GLP-1 receptor upon receptor activation.
    4. beta-arrestin2 mediates beta-2 adrenergic receptor signaling inducing prostate cancer cell progression
      Title: β-arrestin2 mediates β-2 adrenergic receptor signaling inducing prostate cancer cell progression.
    5. beta-Arrestin2 is required for the inhibition of D3R signaling by RGS9-2.
      Title: β-arrestin2 plays permissive roles in the inhibitory activities of RGS9-2 on G protein-coupled receptors by maintaining RGS9-2 in the open conformation.
    6. ARRB2 genotype may thus contribute to the interindividual variability in the response to methadone maintenance treatment and help to predict response to treatment.
      Title: β-Arrestin2 influences the response to methadone in opioid-dependent patients.
    7. the normal subcellular localization of beta-arrestin2 is tightly regulated by the E3 ligase activity of Mdm2.
      Title: Intact MDM2 E3 ligase activity is required for the cytosolic localization and function of β-arrestin2.
    8. serum level of beta-arrestin 2 affected NSCLC patients' prognosis
      Title: [The clinical significance of β-arrestin 2 expression in the serum of non-small cell lung cancer patients].
    9. shows that both beta-arrestin-1 and beta-arrestin-2 play a novel and shared role in inhibiting G protein-dependent ERK1/2 phosphorylation. These findings reveal a new level of complexity for C3aR regulation by beta-arrestins in human mast cells
      Title: Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells.
    10. beta-arrestins can thus differentially control distinct functional outputs of PTEN important for cell proliferation and migration.
      Title: Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins.
    Submit: New GeneRIF Correction See all (108)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_004304.1 NP_065390.1 NFKBIA    BIND  PubMed The amino terminus of Beta-Arr2 interacts with the carboxy terminus of I-kappa-B-alpha to prevent I-kappa-B-alpha phosphorylation and degradation. 
    NP_004304.1 AAC00069.1 PDE4D    BIND  PubMed PDE4D5 interacts with Beta-Arrestin 2. 
    NP_004304.1 NP_004585.1 SLC9A5    BIND  PubMed Beta-Arr2 interacts with NHE5. 
    P32121 P30556 AGTR1    HPRD  PubMed  
    P32121 Q10567 AP1B1    HPRD  PubMed  
    P32121 P62330 ARF6    HPRD  PubMed  
    P32121 P30518 AVPR2    HPRD  PubMed  
    P32121 P21730 C5AR1    HPRD  PubMed  
    P32121 Q00610 CLTC    HPRD  PubMed  
    P32121 P68400 CSNK2A1    HPRD  PubMed  
    P32121 P19784 CSNK2A2    HPRD  PubMed  
    P32121 P61073 CXCR4    HPRD  PubMed  
    P32121 Q99418 CYTH2    HPRD  PubMed  
    P32121 O14641 DVL2    HPRD  PubMed  
    P32121 P21333 FLNA    HPRD  PubMed  
    P32121 Q9ULV1 FZD4    HPRD  PubMed  
    P32121 Q9H422 HIPK3    HPRD  PubMed  
    P32121 P28335 HTR2C    HPRD  PubMed  
    P32121 Q99683 MAP3K5    HPRD  PubMed  
    P32121 P28482 MAPK1    HPRD  PubMed  
    P32121 P53779 MAPK10    HPRD  PubMed  
    P32121 Q00987 MDM2    HPRD  PubMed  
    P32121 Q96G25 MED8    HPRD  PubMed  
    P32121 O75251 NDUFS7    HPRD  PubMed  
    P32121 P25963 NFKBIA    HPRD  PubMed  
    P32121 P30990 NTS    HPRD  PubMed  
    P32121 P30989 NTSR1    HPRD  PubMed  
    P32121 P41143 OPRD1    HPRD  PubMed  
    P32121 P30559 OXTR    HPRD  PubMed  
    P32121 P25105 PTAFR    HPRD  PubMed  
    P32121 P04049 RAF1    HPRD  PubMed  
    P32121 Q12967 RALGDS    HPRD  PubMed  
    P32121 Q14940 SLC9A5    HPRD  PubMed  
    P32121 Q8TAQ2 SMARCC2    HPRD  PubMed  
    P32121 O76061 STC2    HPRD  PubMed  
    P32121 Q03167 TGFBR3    HPRD  PubMed  
    P32121 P20396 TRH    HPRD  PubMed  
    BioGRID:106902 BioGRID:106691 AGTR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106902 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106902 BioGRID:106672 AP2B1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106902 BioGRID:114116 AP3B1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106902 BioGRID:106877 ARF6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106902 BioGRID:106901 ARRB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106902 BioGRID:107035 AVPR2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106902 BioGRID:116850 BOP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106902 BioGRID:107433 CDC42    BioGRID  PubMed Two-hybrid 
    BioGRID:106902 BioGRID:114687 CYTH2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106902 BioGRID:120793 DDX27    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106902 BioGRID:108149 DRD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106902 BioGRID:108399 FBL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106902 BioGRID:114704 GPR56    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106902 BioGRID:109701 IGF1R    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106902 BioGRID:123747 ITCH    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106902 BioGRID:110037 KPNA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106902 BioGRID:110038 KPNA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106902 BioGRID:110161 LHCGR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106902 BioGRID:111590 MAP2K1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106902 BioGRID:112315 MAP2K4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106902 BioGRID:110381 MAP3K5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106902 BioGRID:111580 MAPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106902 BioGRID:111588 MAPK10    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106902 BioGRID:111581 MAPK3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106902 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization 
    BioGRID:106902 BioGRID:125219 MED8    BioGRID  PubMed Two-hybrid 
    BioGRID:106902 BioGRID:124130 MRPL43    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106902 BioGRID:122389 MRPL44    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106902 BioGRID:201372 Mdm2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106902 BioGRID:110811 NEDD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106902 BioGRID:114654 NOLC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106902 BioGRID:207880 Naa10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106902 BioGRID:111030 OPRD1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106902 BioGRID:111105 PARK2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106902 BioGRID:117040 PES1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106902 BioGRID:111516 PPP2R4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106902 BioGRID:111696 PTAFR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106902 BioGRID:115952 PTGES3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106902 BioGRID:111816 RAB5C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106902 BioGRID:111836 RALGDS    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106902 BioGRID:130234 RPL7L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106902 BioGRID:112485 SMARCC2    BioGRID  PubMed Two-hybrid 
    NP_005622.1 SMO    BIND  PubMed Beta-arr2 interacts with Smo. This interaction was modeled on a demonstrated interaction between Beta-arr2 and Smo both from an unspecified species. 
    BioGRID:106902 BioGRID:114172 STC2    BioGRID  PubMed Two-hybrid 
    BioGRID:106902 BioGRID:115563 STUB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106902 BioGRID:112809 TCOF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106902 BioGRID:113039 TRAF3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106902 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; FRET 
    BioGRID:106902 BioGRID:116671 USP33    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • ALK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      ALK1 signaling events, organism-specific biosystem
      ALK1 signaling events
    • Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem (from REACTOME)
      Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystemMature NOTCH1 heterodimer on the cell surface is activated by one of its ligands: DLL1 (Cordle et al. 2008, Jarriault et al. 1998), DLL4 (Benedito et al. 2009), JAG1 (Li et al. 1998, Benedito et al. ...
    • Arf6 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Arf6 signaling events, organism-specific biosystem
      Arf6 signaling events
    • Atypical NF-kappaB pathway, organism-specific biosystem (from Pathway Interaction Database)
      Atypical NF-kappaB pathway, organism-specific biosystem
      Atypical NF-kappaB pathway
    • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR4-mediated signaling events, organism-specific biosystem
      CXCR4-mediated signaling events
    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Hedgehog signaling events mediated by Gli proteins, organism-specific biosystem (from Pathway Interaction Database)
      Hedgehog signaling events mediated by Gli proteins, organism-specific biosystem
      Hedgehog signaling events mediated by Gli proteins
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Morphine addiction, organism-specific biosystem (from KEGG)
      Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Morphine addiction, conserved biosystem (from KEGG)
      Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Nephrin/Neph1 signaling in the kidney podocyte, organism-specific biosystem (from Pathway Interaction Database)
      Nephrin/Neph1 signaling in the kidney podocyte, organism-specific biosystem
      Nephrin/Neph1 signaling in the kidney podocyte
    • Noncanonical Wnt signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Noncanonical Wnt signaling pathway, organism-specific biosystem
      Noncanonical Wnt signaling pathway
    • Olfactory transduction, organism-specific biosystem (from KEGG)
      Olfactory transduction, organism-specific biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
    • Olfactory transduction, conserved biosystem (from KEGG)
      Olfactory transduction, conserved biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
    • Phototransduction, organism-specific biosystem (from KEGG)
      Phototransduction, organism-specific biosystemPhototransduction is a biochemical process by which the photoreceptor cells generate electrical signals in response to captured photons. The vertebrate cascade starts with the absorption of photons b...
    • Phototransduction, conserved biosystem (from KEGG)
      Phototransduction, conserved biosystemPhototransduction is a biochemical process by which the photoreceptor cells generate electrical signals in response to captured photons. The vertebrate cascade starts with the absorption of photons b...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
    • Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1, organism-specific biosystemNOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a me...
    • Signaling events mediated by the Hedgehog family, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by the Hedgehog family, organism-specific biosystem
      Signaling events mediated by the Hedgehog family
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • TGF-beta receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      TGF-beta receptor signaling, organism-specific biosystem
      TGF-beta receptor signaling
    • Thrombin signalling through proteinase activated receptors (PARs), organism-specific biosystem (from REACTOME)
      Thrombin signalling through proteinase activated receptors (PARs), organism-specific biosystemThrombin activates proteinase activated receptors (PARs) that signal through heterotrimeric G proteins of the G12/13 and Gq families, thereby connecting to a host of intracellular signaling pathways....
    • Thromboxane A2 receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Thromboxane A2 receptor signaling, organism-specific biosystem
      Thromboxane A2 receptor signaling
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    angiotensin receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor internalization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    G-protein coupled receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    desensitization of G-protein coupled receptor protein signaling pathway by arrestin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    platelet activation TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    receptor internalization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasmic membrane-bounded vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    beta-arrestin-2
    Names
    beta-arrestin-2
    arrestin 3
    arrestin beta-2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257328.1 → NP_001244257.1  beta-arrestin-2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AB209786, AK297181, BC007427, BG723452
      Conserved Domains (1) summary
      cl02844
      Location:19 – 196
      Blast Score: 254
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    2. NM_001257329.1 → NP_001244258.1  beta-arrestin-2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 3' end of an exon and uses an alternate splice junction at the 3' end of another exon, that causes a frameshift. The resulting isoform (4) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 3.
      Source sequence(s)
      BC007427, BC095450, BG723452
      Conserved Domains (1) summary
      cl02844
      Location:19 – 175
      Blast Score: 289
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    3. NM_001257330.1 → NP_001244259.1  beta-arrestin-2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice junction at the 3' end of an exon and uses an alternate in-frame splice junction at the 5' end of another exon compared to variant 3. The resulting isoform (5) lacks an alternate internal segment and contains another alternate internal segment compared to isoform 3.
      Source sequence(s)
      BC007427, BG723452, DQ664180
      UniProtKB/Swiss-Prot
      P32121
      Conserved Domains (1) summary
      cl02844
      Location:19 – 175
      Blast Score: 284
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    4. NM_001257331.1 → NP_001244260.1  beta-arrestin-2 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon, uses an alternate in-frame splice junction at the 3' end of an exon, and uses an alternate in-frame splice junction at the 5' end of another exon compared to variant 3. The resulting isoform (6) lacks two alternate internal segments and contains another alternate internal segment compared to isoform 3.
      Source sequence(s)
      AK097542, BC007427, BG723452, DQ664180
      UniProtKB/Swiss-Prot
      P32121
      Conserved Domains (1) summary
      cl02844
      Location:19 – 160
      Blast Score: 268
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    5. NM_004313.3 → NP_004304.1  beta-arrestin-2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 3. The resulting isoform (1) lacks an alternate internal segment compared to isoform 3.
      Source sequence(s)
      AF106941, BC007427, BG723452
      Consensus CDS
      CCDS11050.1
      UniProtKB/Swiss-Prot
      P32121
      Related
      ENSP00000269260, ENST00000269260
      Conserved Domains (1) summary
      cl02844
      Location:19 – 175
      Blast Score: 284
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    6. NM_199004.1 → NP_945355.1  beta-arrestin-2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 3' end of another exon compared to variant 3. The resulting isoform (2) lacks two alternate internal segments compared to isoform 3.
      Source sequence(s)
      AF106941, AK097542, BC007427, BG723452
      Consensus CDS
      CCDS11051.1
      UniProtKB/TrEMBL
      G5E980
      UniProtKB/Swiss-Prot
      P32121
      Related
      ENSP00000370898, OTTHUMP00000115951, ENST00000381488, OTTHUMT00000207504
      Conserved Domains (1) summary
      cl02844
      Location:19 – 160
      Blast Score: 269
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RNA

    1. NR_047516.1 RNA Sequence

      Description
      Transcript Variant: This variant (7) lacks an alternate coding exon compared to isoform 3, that causes a frameshift. The resulting transcript could encode a 217 aa isoform but instead is thought to be non-protein coding due to the presence of an upstream open reading frame with a strong Kozak signal. Translation beginning at that start site renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB209786, BC007427, BG723452

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      4613789..4624795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      4502952..4513866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC091153.10 (60534..71540) None
    genomic CH471108.2 EAW90419.1
      EAW90420.1
      EAW90421.1
      EAW90422.1
    genomic DQ314866.1 ABC40725.1
    mRNA AB209786.1 BAD93023.1
    mRNA AF106941.1 AAC99468.1
    mRNA AK097542.1 BAC05094.1
    mRNA AK290951.1 BAF83640.1
    mRNA AK297059.1 BAG59581.1
    mRNA AK297181.1 BAG59672.1
    mRNA BC007427.2 AAH07427.1
    mRNA BC039066.1 None
    mRNA BC067368.1 AAH67368.1
    mRNA BC095450.1 None
    mRNA BG723452.1 None
    mRNA CR450310.1 CAG29306.1
    mRNA CR749218.1 CAH18075.1
    mRNA DQ664180.1 ABG47460.1
    mRNA EU883572.1 ACG60646.1
    mRNA Z11501.1 CAA77577.1
    other-genetic DQ893226.2 ABM84152.1
    other-genetic DQ896556.2 ABM87555.1
    other-genetic EU176778.1 ABW03579.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32121.2 GenPept UniProtKB/Swiss-Prot:P32121
    Q59EM5 GenPept UniProtKB/TrEMBL:Q59EM5
    Q68DZ5 GenPept UniProtKB/TrEMBL:Q68DZ5
    Help top of page

    Additional Links

    Gene LinkOut

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