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    SMAD2 SMAD family member 2 [ Homo sapiens ]

    Gene ID: 4087, updated on 19-May-2012
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    Summary

    Official Symbol
    SMAD2provided by HGNC
    Official Full Name
    SMAD family member 2provided by HGNC
    Primary source
    HGNC:6768
    See related
    Ensembl:ENSG00000175387; HPRD:03221; MIM:601366; Vega:OTTHUMG00000132652
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2; MGC22139; MGC34440
    Summary
    The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
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    Genomic context

    Location :
    18q21.1
    Sequence :
    Chromosome: 18; NC_000018.9 (45359466..45457515, complement)
    See SMAD2 in Epigenomics, MapViewer

    Chromosome 18 - NC_000018.9Genomic Context describing neighboring genes Neighboring gene microRNA 4527 Neighboring gene thiopurine S-methyltransferase pseudogene 1 Neighboring gene zinc finger and BTB domain containing 7C Neighboring gene uncharacterized LOC100127909 Neighboring gene chromosome 18 open reading frame 12

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Histone deacetylase inhibitors upregulate MMP11 gene expression through Sp1/Smad complexes in human colon adenocarcinoma cells. Barrasa JI, et al. Biochim Biophys Acta, 2012 Feb. PMID 22227581.
    2. A poised chromatin platform for TGF-β access to master regulators. Xi Q, et al. Cell, 2011 Dec 23. PMID 22196728.
    3. Crosstalk between nuclear factor I-C and transforming growth factor-β1 signaling regulates odontoblast differentiation and homeostasis. Lee DS, et al. PLoS One, 2011. PMID 22195013.
    4. PPM1A dephosphorylates RanBP3 to enable efficient nuclear export of Smad2 and Smad3. Dai F, et al. EMBO Rep, 2011 Oct 28. PMID 21960005.
    5. USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Inui M, et al. Nat Cell Biol, 2011 Sep 25. PMID 21947082.

    See all (318) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Protein phosphatase PPM1A regulates the nuclear export of Smad2/3 through targeting nuclear exporter RanBP3.
      Title: PPM1A dephosphorylates RanBP3 to enable efficient nuclear export of Smad2 and Smad3.
    2. pattern of Smad2 activation supports a model in which TGFbeta/activin signaling is anti-atherogenic in the media of normal artery walls but is equally compatible with an anti-atherogenic or pro-atherogenic response to TGFbeta/activin in neointima of le...
      Title: TGFβ/activin signaling pathway activation in intimal hyperplasia and atherosclerosis.
    3. SMAD2 polymorphisms may be one of genetic determinants of BMD in postmenopausal women
      Title: Association of SMAD2 polymorphisms with bone mineral density in postmenopausal Korean women.
    4. specific inhibition of SMAD-2/3 signaling pathway in hESCs facilitates the conversion of hESCs into multipotent MSCs with fully immunosuppresive and anti-inflammatory properties in vivo, opening up new avenues for potential future clinical applications.
      Title: Enrichment of human ESC-derived multipotent mesenchymal stem cells with immunosuppressive and anti-inflammatory properties capable to protect against experimental inflammatory bowel disease.
    5. l type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4alpha in HepG2 cells.
      Title: Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4alpha in HepG2 cells.
    6. The Smad2 was highly expressed in VKC conjunctiva in association with TGF-b1.
      Title: Transforming growth factor-β/Smad - signalling pathway and conjunctival remodelling in vernal keratoconjunctivitis.
    7. HEB and E2A-bind the SCA motif at regions overlapping SMAD2/3 and FOXH1
      Title: HEB and E2A function as SMAD/FOXH1 cofactors.
    8. In malignant cells with a functional TGF-beta signalling pathway Rac1 antagonizes the TGF-beta1 growth inhibitory response and enhances cell migration by antagonistically regulating Smad2 and Smad3 activation
      Title: Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1.
    9. Smad2 was both preferentially phosphorylated in the linker region and localized to the nucleus in a flow-dependent manner
      Title: Flow-dependent Smad2 phosphorylation and TGIF nuclear localization in human aortic endothelial cells.
    10. Activin A-ACVRIB/ALK4-Smad-dependent collagen production was augmented in SSc fibroblasts, suggesting the involvement of this signaling mechanism in systemic sclerosis.
      Title: Activation of the activin A-ALK-Smad pathway in systemic sclerosis.
    Submit: New GeneRIF Correction See all (120)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 and p300 synergistically increase TGF-beta, ATF-2 and activating protein-1 (AP-1) expression leading to tubular cell apoptosis; in addition, HIV-1 gp120 treatment causes phosphorylation of Smad2 and downregulation of c-Jun PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001003652.1 NP_002666.1 PML    BIND  PubMed cPML interacts with Smad2. 
    NP_005892.1 NP_055700.1 ANAPC10    BIND  PubMed Smad2 interacts with APC10. 
    NP_005892.1 NP_009226.1 BRCA1    BIND  PubMed BRCA1 interacts with Smad2. This interaction was modeled on a demonstrated interaction between BRCA1 from human and Smad2 from an unspecified species. 
    NP_005892.1 NP_001789.2 CDK2    BIND  PubMed CDK2 phosphorylates Smad2. This interaction was modelled on a demonstrated interaction between Smad2 from an unspecified species and human CDK2. 
    NP_005892.1 NP_000066.1 CDK4    BIND  PubMed CDK4 phosphorylates Smad2. This interaction was modelled on a demonstrated interaction between Smad2 from an unspecified species and mouse CDK4. 
    NP_005892.1 NP_004371.1 CREBBP    BIND  PubMed CBP interacts with Smad2. This interaction was modeled on a demonstrated interaction between mouse CBP and Smad2 from an unspecified species. 
    NP_005892.1 NP_004371.1 CREBBP    BIND  PubMed CBP interacts with Smad2. This interaction was modeled on a demonstrated interaction between CBP from an unspecified species and human Smad2. 
    NP_005892.1 NP_040910.1 E1A    BIND  PubMed E1A interacts with Smad2. This interaction was modeled on a demonstrated interaction between E1A from an unspecified adenovirus and Smad2 from an unspecified source. 
    NP_005892.1 NP_001420.2 EP300    BIND  PubMed p300 interacts with Smad2. This interaction was modeled on a demonstrated interaction between p300 from an unspecified species and human Smad2. 
    NP_005892.1 NP_003914.1 FOXH1    BIND  PubMed The SIM motif of FoxH1 interacts with Smad2. This interaction was modeled on a demonstrated interaction between human FoxH1 and Smad2 from an unspecified species. 
    NP_005892.1 NP_003914.1 FOXH1    BIND  PubMed FoxH1 interacts with Smad2. This interaction was modelled on a demonstrated interaction between FoxH1 from an unspecified species and Smad3 from an unspecified species. 
    NP_005892.1 NP_055134.2 LEMD3    BIND  PubMed LEMD3 interacts with Smad2. This interaction was modelled on a demonstrated interaction between human LEMD3 and mouse Smad2. 
    NP_005892.1 NP_003027.1 SKI    BIND  PubMed c-Ski interacts with Smad2. This interaction was modeled on a demonstrated interaction between Smad2 from an unspecified source and human c-Ski. 
    NP_005892.1 NP_005405.1 SKIL    BIND  PubMed Smad2 interacts with SnoN. This interaction was modeled on a demonstrated interaction between SnoN from an unspecified source and human Smad2. 
    NP_005892.1 NP_005893.1 SMAD3    BIND  PubMed Smad2 interacts with Smad3. This interaction was modeled on a demonstrated interaction between Smad2 from an unspecified species and Smad3 from an unspecified species. 
    NP_005892.1 NP_005893.1 SMAD3    BIND  PubMed SMAD3 interacts with SMAD2. 
    NP_005892.1 NP_005350.1 SMAD4    BIND  PubMed Smad2 interacts with Smad4. This interaction was modeled on a demonstrated interaction between Smad2 from an unspecified species and Smad4 from an unspecified species. 
    NP_005892.1 NP_005350.1 SMAD4    BIND  PubMed Smad4 interacts with Smad2. 
    NP_005892.1 NP_073576.1 SMURF2    BIND  PubMed SMAD2 interacts with SMURF2. 
    NP_005892.1 NP_036377.1 SNW1    BIND  PubMed SKIP interacts with Smad2. This interaction was modeled on a demonstrated interaction between human SKIP and Smad2 from an unspecified source. 
    NP_005892.1 NP_004603.1 TGFBR1    BIND  PubMed T-beta-RI interacts with Smad2. 
    NP_005892.1     BIND  PubMed T-beta-R1/T-beta-R2 complex interacts with Smad2. This interaction was modeled on a demonstrated interaction between T-beta-R1/T-beta-R2 complex and Smad2 both from unspecified species. 
    NP_005892.1     BIND  PubMed T-beta-R1/T-beta-R2 complex phosphorylates Smad2. This interaction was modeled on a demonstrated interaction between mouse T-beta-R1/T-beta-R2 complex and Smad2 from an unspecified species. 
    Q15796 Q969K4 ABTB1    HPRD  PubMed  
    Q15796 P36896 ACVR1B    HPRD  PubMed  
    Q15796 P31749 AKT1    HPRD  PubMed  
    Q15796 Q9UM13 ANAPC10    HPRD  PubMed  
    Q15796 Q9UJX6 ANAPC2    HPRD  PubMed  
    Q15796 Q12955 ANK3    HPRD  PubMed  
    Q15796 P58335 ANTXR2    HPRD  PubMed  
    Q15796 Q10567 AP1B1    HPRD  PubMed  
    Q15796 Q9NP61 ARFGAP3    HPRD  PubMed  
    Q15796 Q15052 ARHGEF6    HPRD  PubMed  
    Q15796 P49703 ARL4D    HPRD  PubMed  
    Q15796 O15169 AXIN1    HPRD  PubMed  
    Q15796 Q9NRL2 BAZ1A    HPRD  PubMed  
    Q15796 P38398 BRCA1    HPRD  PubMed  
    Q15796 Q9BX70 BTBD2    HPRD  PubMed  
    Q15796 Q9UQM7 CAMK2A    HPRD  PubMed  
    Q15796 Q13042 CDC16    HPRD  PubMed  
    Q15796 P30260 CDC27    HPRD  PubMed  
    Q15796 O60508 CDC40    HPRD  PubMed  
    Q15796 P11802 CDK4    HPRD  PubMed  
    Q15796 Q9NSE2 CISH    HPRD  PubMed  
    Q15796 Q92905 COPS5    HPRD  PubMed  
    Q15796 Q92793 CREBBP    HPRD  PubMed  
    Q15796 Chorionic somatomammotropin hormone 1 CSH1    HPRD  PubMed  
    Q15796 P35222 CTNNB1    HPRD  PubMed  
    Q15796 Q93034 CUL5    HPRD  PubMed  
    Q15796 P05108 CYP11A1    HPRD  PubMed  
    Q15796 P98082 DAB2    HPRD  PubMed  
    Q15796 IQ motif and WD repeats 1 DCAF6    HPRD  PubMed  
    Q15796 Q96GG9 DCUN1D1    HPRD  PubMed  
    Q15796 Q99615 DNAJC7    HPRD  PubMed  
    Q15796 O14640 DVL1    HPRD  PubMed  
    Q15796 Q14204 DYNC1H1    HPRD  PubMed  
    Q15796 Q16254 E2F4    HPRD  PubMed  
    Q15796 P68104 EEF1A1    HPRD  PubMed  
    Q15796 CREBBP/EP300 inhibitor 2 EID2    HPRD  PubMed  
    Q15796 Q9Y262 EIF3L    HPRD  PubMed  
    Q15796 Q09472 EP300    HPRD  PubMed  
    Q15796 Q96RT1 ERBB2IP    HPRD  PubMed  
    Q15796 P03372 ESR1    HPRD  PubMed  
    Q15796 Q92731 ESR2    HPRD  PubMed  
    Q15796 P35556 FBN2    HPRD  PubMed  
    Q15796 P55315 FOXG1    HPRD  PubMed  
    Q15796 O75593 FOXH1    HPRD  PubMed  
    Q15796 O43524 FOXO3    HPRD  PubMed  
    Q15796 Q8WXI9 GATAD2B    HPRD  PubMed  
    Q15796 P10071 GLI3    HPRD  PubMed  
    Q15796 Q4V328 GRIPAP1    HPRD  PubMed  
    Q15796 P56915 GSC    HPRD  PubMed  
    Q15796 P78347 GTF2I    HPRD  PubMed  
    Q15796 Q13547 HDAC1    HPRD  PubMed  
    Q15796 O14964 HGS    HPRD  PubMed  
    Q15796 Q9H2X6 HIPK2    HPRD  PubMed  
    Q15796 P41235 HNF4A    HPRD  PubMed  
    Q15796 P31271 HOXA13    HPRD  PubMed  
    Q15796 P31269 HOXA9    HPRD  PubMed  
    Q15796 P35453 HOXD13    HPRD  PubMed  
    Q15796 Q7Z6Z7 HUWE1    HPRD  PubMed  
    Q15796 P06213 INSR    HPRD  PubMed  
    Q15796 O43187 IRAK2    HPRD  PubMed  
    Q15796 P05412 JUN    HPRD  PubMed  
    Q15796 Q92831 KAT2B    HPRD  PubMed  
    Q15796 Q07666 KHDRBS1    HPRD  PubMed  
    Q15796 Q14974 KPNB1    HPRD  PubMed  
    Q15796 O15230 LAMA5    HPRD  PubMed  
    Q15796 Q9UJU2 LEF1    HPRD  PubMed  
    Q15796 Q9Y2U8 LEMD3    HPRD  PubMed  
    Q15796 Q9NQ69 LHX9    HPRD  PubMed  
    Q15796 Q99732 LITAF    HPRD  PubMed  
    Q15796 P25791 LMO2    HPRD  PubMed  
    Q15796 P28482 MAPK1    HPRD  PubMed  
    Q15796 P27361 MAPK3    HPRD  PubMed  
    Q15796 P45983 MAPK8    HPRD  PubMed  
    Q15796 P45984 MAPK9    HPRD  PubMed  
    Q15796 Q96RN5 MED15    HPRD  PubMed  
    Q15796 O75586 MED6    HPRD  PubMed  
    Q15796 Q02078 MEF2A    HPRD  PubMed  
    Q15796 Q06413 MEF2C    HPRD  PubMed  
    Q15796 P55196 MLLT4    HPRD  PubMed  
    Q15796 P01106 MYC    HPRD  PubMed  
    Q15796 Q9UJ70 NAGK    HPRD  PubMed  
    Q15796 Q14686 NCOA6    HPRD  PubMed  
    Q15796 Q14511 NEDD9    HPRD  PubMed  
    Q15796 Q13952 NFYC    HPRD  PubMed  
    Q15796 Q99466 NOTCH4    HPRD  PubMed  
    Q15796 Q9H093 NUAK2    HPRD  PubMed  
    Q15796 P49790 NUP153    HPRD  PubMed  
    Q15796 P35658 NUP214    HPRD  PubMed  
    Q15796 Q13438 OS9    HPRD  PubMed  
    Q15796 Q13153 PAK1    HPRD  PubMed  
    Q15796 P51003 PAPOLA    HPRD  PubMed  
    Q15796 Q13219 PAPPA    HPRD  PubMed  
    Q15796 Q8TEW0 PARD3    HPRD  PubMed  
    Q15796 P40855 PEX19    HPRD  PubMed  
    Q15796 Q9Y6X2 PIAS3    HPRD  PubMed  
    Q15796 Q8N2W9 PIAS4    HPRD  PubMed  
    Q15796 O60664 PLIN3    HPRD  PubMed  
    Q15796 P35813 PPM1A    HPRD  PubMed  
    Q15796 P30153 PPP2R1A    HPRD  PubMed  
    Q15796 P10644 PRKAR1A    HPRD  PubMed  
    Q15796 P07602 PSAP    HPRD  PubMed  
    Q15796 Q00887 PSG9    HPRD  PubMed  
    Q15796 O00231 PSMD11    HPRD  PubMed  
    Q15796 P48556 PSMD8    HPRD  PubMed  
    Q15796 Q9BZG1 RAB34    HPRD  PubMed  
    Q15796 P57729 RAB38    HPRD  PubMed  
    Q15796 P62826 RAN    HPRD  PubMed  
    Q15796 Q96S59 RANBP9    HPRD  PubMed  
    Q15796 P10826 RARB    HPRD  PubMed  
    Q15796 Q96D21 RASD2    HPRD  PubMed  
    Q15796 RAS like family 12 protein RASL12    HPRD  PubMed  
    Q15796 P28749 RBL1    HPRD  PubMed  
    Q15796 Ras homolog enriched in brain like 1 RHEBL1    HPRD  PubMed  
    Q15796 O00212 RHOD    HPRD  PubMed  
    Q15796 Q9H4E5 RHOJ    HPRD  PubMed  
    Q15796 Q92963 RIT1    HPRD  PubMed  
    Q15796 Q5XPI4 RNF123    HPRD  PubMed  
    Q15796 Q13464 ROCK1    HPRD  PubMed  
    Q15796 P62263 RPS14    HPRD  PubMed  
    Q15796 P62979 RPS27A    HPRD  PubMed  
    Q15796 Q13950 RUNX2    HPRD  PubMed  
    Q15796 P19793 RXRA    HPRD  PubMed  
    Q15796 P12755 SKI    HPRD  PubMed  
    Q15796 P12757 SKIL    HPRD  PubMed  
    Q15796 Q15796 SMAD2    HPRD  PubMed  
    Q15796 P84022 SMAD3    HPRD  PubMed  
    Q15796 Q13485 SMAD4    HPRD  PubMed  
    Q15796 Q13485 SMAD4    HPRD  PubMed  
    Q15796 O15198 SMAD9    HPRD  PubMed  
    Q15796 Q9HAU4 SMURF2    HPRD  PubMed  
    Q15796 O95295 SNAPIN    HPRD  PubMed  
    Q15796 Q8TAD8 SNIP1    HPRD  PubMed  
    Q15796 P08621 SNRNP70    HPRD  PubMed  
    Q15796 Q13573 SNW1    HPRD  PubMed  
    Q15796 P08047 SP1    HPRD  PubMed  
    Q15796 Q13501 SQSTM1    HPRD  PubMed  
    Q15796 P30626 SRI    HPRD  PubMed  
    Q15796 P50502 ST13    HPRD  PubMed  
    Q15796 P78524 ST5    HPRD  PubMed  
    Q15796 Q8WVM7 STAG1    HPRD  PubMed  
    Q15796 O95630 STAMBP    HPRD  PubMed  
    Q15796 Q96FJ0 STAMBPL1    HPRD  PubMed  
    Q15796 Q9Y3F4 STRAP    HPRD  PubMed  
    Q15796 Q9UNE7 STUB1    HPRD  PubMed  
    Q15796 Q86TI0 TBC1D1    HPRD  PubMed  
    Q15796 P36897 TGFBR1    HPRD  PubMed  
    Q15796 TGF beta receptor associated protein 1 TGFBRAP1    HPRD  PubMed  
    Q15796 Q15583 TGIF1    HPRD  PubMed  
    Q15796 P21980 TGM2    HPRD  PubMed  
    Q15796 P13805 TNNT1    HPRD  PubMed  
    Q15796 P50616 TOB1    HPRD  PubMed  
    Q15796 P04637 TP53    HPRD  PubMed  
    Q15796 O15350 TP73    HPRD  PubMed  
    Q15796 Q9BVG3 TRIM62    HPRD  PubMed  
    Q15796 P49815 TSC2    HPRD  PubMed  
    Q15796 P62987 UBA52    HPRD  PubMed  
    Q15796 O95071 UBR5    HPRD  PubMed  
    Q15796 Chromosome 16 open reading frame 28 UNKL    HPRD  PubMed  
    Q15796 P37275 ZEB1    HPRD  PubMed  
    Q15796 O60315 ZEB2    HPRD  PubMed  
    Q15796 O95405 ZFYVE9    HPRD  PubMed  
    Q15796 Q15326 ZMYND11    HPRD  PubMed  
    Q15796 P51814 ZNF41    HPRD  PubMed  
    Q15796 P17098 ZNF8    HPRD  PubMed  
    Q15796 Q9NWK9 ZNHIT6    HPRD  PubMed  
    Q15796 Functional smad suppressing element 18     HPRD  PubMed  
    Q15796 Hypothetical FLJ23584     HPRD  PubMed  
    BioGRID:110262 BioGRID:106606 ACVR1B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:115665 ANAPC10    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110262 BioGRID:113894 ARID1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110262 BioGRID:121559 ARID1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110262 BioGRID:106957 ATF3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:201115 Arhgef1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:215941 Arhgef6    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:207566 Arhgef7    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:219856 Arl4d    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:108481 BPTF    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110262 BioGRID:107142 BRCA2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:107268 CAMK2G    BioGRID  PubMed Biochemical Activity 
    BioGRID:110262 BioGRID:107305 CAV1    BioGRID  PubMed Co-fractionation 
    BioGRID:110262 BioGRID:114400 CDC16    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:107431 CDC27    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:107458 CDK8    BioGRID  PubMed Biochemical Activity 
    BioGRID:110262 BioGRID:107459 CDK9    BioGRID  PubMed Biochemical Activity 
    BioGRID:110262 BioGRID:115649 CITED2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110262 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:214875 Cdc40    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:107971 DAB2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110262 BioGRID:108188 DVL1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110262 BioGRID:127852 EID2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:120997 ERBB2IP    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:110262 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110262 BioGRID:114442 FOXH1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110262 BioGRID:208300 Fbxo3    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:109224 GTF2I    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:114939 GTF2IRD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:118815 HIPK2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110262 BioGRID:109834 ING2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:109854 INSR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110262 BioGRID:123747 ITCH    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:110262 BioGRID:224495 Irak2    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:109928 JUN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:108918 KAT2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:114375 KAT2B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110262 BioGRID:116752 KDM6B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:119354 LEF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110262 BioGRID:201161 Lhx9    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:201179 Lmo2    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:108423 MECOM    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110262 BioGRID:119623 MED15    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:115196 MED24    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:115319 MED6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:110369 MEF2A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110262 BioGRID:110372 MEF2C    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110262 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110262 BioGRID:125044 MYOCD    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110262 BioGRID:204951 Map2k3    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:113841 NCOA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110262 BioGRID:110811 NEDD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:110816 NEDD9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:110836 NF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110262 BioGRID:110868 NFYC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:113717 NUP214    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110262 BioGRID:216519 Nuak2    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:125592 PARD3B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110262 BioGRID:115673 PIAS3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110262 BioGRID:119624 PIAS4    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110262 BioGRID:111317 PIN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110262 BioGRID:111384 PML    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:111446 POU2AF1    BioGRID  PubMed Two-hybrid 
    BioGRID:110262 BioGRID:122023 PRDM16    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:206582 Ppp2r2d    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:120146 RNF111    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:107309 RUNX1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:107308 RUNX2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:107312 RUNX3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:202576 Rab34    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:215371 Rab38    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:217250 Rasd2    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:206112 Rgs3    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:213261 Rhebl1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:213337 Rhobtb1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:198198 Rhod    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:219817 Rhoj    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:220311 Rnf111    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:219309 Rps27a    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:112388 SKI    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110262 BioGRID:112389 SKIL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:110262 SMAD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement 
    BioGRID:110262 BioGRID:110264 SMAD4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid 
    BioGRID:110262 BioGRID:110266 SMAD6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:110267 SMAD7    BioGRID  PubMed Phenotypic Suppression; Reconstituted Complex 
    BioGRID:110262 BioGRID:112481 SMARCA4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110262 BioGRID:112483 SMARCC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110262 BioGRID:112485 SMARCC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110262 BioGRID:121411 SMURF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:122265 SMURF2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110262 BioGRID:122864 SNIP1    BioGRID  PubMed Two-hybrid 
    BioGRID:110262 BioGRID:116597 SNW1    BioGRID  PubMed Phenotypic Enhancement; Reconstituted Complex; Two-hybrid 
    BioGRID:110262 BioGRID:112545 SOX9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110262 BioGRID:116342 STRAP    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression 
    BioGRID:110262 BioGRID:115563 STUB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110262 BioGRID:211588 Sip1    BioGRID  PubMed Two-hybrid 
    BioGRID:110262 BioGRID:201275 Smad2    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:201276 Smad3    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:201982 Sqstm1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:112898 TGFB1    BioGRID  PubMed Co-localization 
    BioGRID:110262 BioGRID:112904 TGFBR1    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:110262 BioGRID:112908 TGIF1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110262 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110262 BioGRID:119625 TRIM33    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110262 BioGRID:211764 Trim35    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110262 BioGRID:119509 UCHL5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110262 BioGRID:115283 USP15    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:113867 USP9X    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:200956 Uhmk1    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:116243 WWP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:116244 WWP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:211793 Wwp2    BioGRID  PubMed Affinity Capture-Luminescence 
    BioGRID:110262 BioGRID:113360 YY1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110262 BioGRID:112796 ZEB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110262 BioGRID:114773 ZFYVE9    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem"Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligand...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Colorectal cancer, organism-specific biosystem (from KEGG)
      Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Colorectal cancer, conserved biosystem (from KEGG)
      Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Glypican 1 network, organism-specific biosystem (from Pathway Interaction Database)
      Glypican 1 network, organism-specific biosystem
      Glypican 1 network
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Regulation of cytoplasmic and nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of cytoplasmic and nuclear SMAD2/3 signaling, organism-specific biosystem
      Regulation of cytoplasmic and nuclear SMAD2/3 signaling
    • Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
      Regulation of nuclear SMAD2/3 signaling
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by NODAL, organism-specific biosystem (from REACTOME)
      Signaling by NODAL, organism-specific biosystemSignaling by NODAL is essential for patterning of the axes of the embryo and formation of mesoderm and endoderm (reviewed in Schier 2009, Shen 2007). The NODAL proprotein is secreted and cleaved extr...
    • Signaling by TGF beta, organism-specific biosystem (from REACTOME)
      Signaling by TGF beta, organism-specific biosystemThe TGF-beta/BMP pathway incorporates several signalling pathways that share most, but not all, components of a central signal transduction engine. The general signalling scheme is rather simple: upo...
    • TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • TGF-beta receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      TGF-beta receptor signaling, organism-specific biosystem
      TGF-beta receptor signaling
    • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
      TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • TGF-beta signaling pathway, conserved biosystem (from KEGG)
      TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    I-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    R-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    SMAD binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    activating transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    co-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    double-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transforming growth factor beta receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    type I transforming growth factor beta receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    SMAD protein complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    anterior/posterior pattern specification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cell fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    common-partner SMAD protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    developmental growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryonic cranial skeleton morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryonic foregut morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryonic pattern specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoderm development IEA
    Inferred from Electronic Annotation
    more info
    		  
    gastrulation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    insulin secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    lung development IEA
    Inferred from Electronic Annotation
    more info
    		  
    mesoderm formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription, DNA-dependent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    organ growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    palate development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    pancreas development IEA
    Inferred from Electronic Annotation
    more info
    		  
    paraxial mesoderm morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    pericardium development IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of epithelial to mesenchymal transition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    primary miRNA processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    response to cholesterol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transforming growth factor beta receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
    		  
    zygotic specification of dorsal/ventral axis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    SMAD protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    activin responsive factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    intracellular ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    mothers against decapentaplegic homolog 2
    Names
    mothers against decapentaplegic homolog 2
    MAD homolog 2
    mother against DPP homolog 2
    Sma- and Mad-related protein 2
    SMAD, mothers against DPP homolog 2
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029946.1 RefSeqGene

      Range
      4999..103050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001003652.3 → NP_001003652.1  mothers against decapentaplegic homolog 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC120349, AI453799, BC025699, DB035686, DB462454
      Consensus CDS
      CCDS11934.1
      UniProtKB/Swiss-Prot
      Q15796
      UniProtKB/TrEMBL
      Q53XR6
      Related
      ENSP00000384449, ENST00000402690
      Conserved Domains (2) summary
      cd10491
      Location:8 – 172
      Blast Score: 495
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 – 456
      Blast Score: 1090
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    2. NM_001135937.2 → NP_001129409.1  mothers against decapentaplegic homolog 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as SMAD2Deltaexon3) lacks an in-frame exon in the 5' coding region, compared to variant 2, resulting in an isoform (2) that is shorter than isoform 1. There are no publicly available full-length transcripts representing this variant, but it is supported by data in Taekenoshita et al. (1998; PMID: 9503010) and Yagi et al. (1999; PMID: 9873005).
      Source sequence(s)
      AC120349, AI453799, AK299218, DB035686, DB462454
      UniProtKB/Swiss-Prot
      Q15796
      Related
      ENSP00000349282, ENST00000356825
      Conserved Domains (2) summary
      cd10491
      Location:8 – 142
      Blast Score: 536
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:236 – 426
      Blast Score: 1093
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    3. NM_005901.5 → NP_005892.1  mothers against decapentaplegic homolog 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate exon (1b) in the 5' UTR compared to variant 2. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC120349, AI453799, BC014840, CR992221
      Consensus CDS
      CCDS11934.1
      UniProtKB/Swiss-Prot
      Q15796
      UniProtKB/TrEMBL
      Q53XR6
      Related
      ENSP00000262160, OTTHUMP00000163489, ENST00000262160, OTTHUMT00000255903
      Conserved Domains (2) summary
      cd10491
      Location:8 – 172
      Blast Score: 495
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 – 456
      Blast Score: 1090
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000018.9 Reference GRCh37.p5 Primary Assembly

      Range
      45359466..45457515, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000150.1 Alternate HuRef

      Range
      42208822..42306923, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC120349.5 (27959..125715) None
    genomic CH471096.1 EAW62914.1
      EAW62915.1
      EAW62916.1
      EAW62917.1
    genomic U78733.1 AAC39657.1
    mRNA AA081871.1 None
    mRNA AA418737.1 None
    mRNA AF027964.1 AAC51918.1
    mRNA AI087928.1 None
    mRNA AI453799.1 None
    mRNA AI765747.1 None
    mRNA AK126373.1 None
    mRNA AK299218.1 BAH12971.1
    mRNA AK312963.1 BAG35802.1
    mRNA AY134745.1 AAN08619.1
    mRNA BC014840.1 AAH14840.1
    mRNA BC025699.1 AAH25699.1
    mRNA BI258844.1 None
    mRNA BQ018815.1 None
    mRNA BQ900993.1 None
    mRNA BT007422.1 AAP36090.1
    mRNA BU167620.1 None
    mRNA BU517178.1 None
    mRNA BX491944.1 None
    mRNA DB035686.1 None
    mRNA DB462454.1 None
    mRNA DC371139.1 None
    mRNA U59911.1 AAC50789.1
    mRNA U65019.1 AAB17054.1
    mRNA U68018.1 AAB17087.1
    other-genetic DQ891501.2 ABM82427.1
    other-genetic DQ893532.2 ABM84458.1
    other-genetic DQ893746.2 ABM84672.1
    other-genetic DQ894693.2 ABM85619.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15796.1 GenPept UniProtKB/Swiss-Prot:Q15796
    Q53XR6 GenPept UniProtKB/TrEMBL:Q53XR6
    Q7Z5E4 GenPept UniProtKB/TrEMBL:Q7Z5E4
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