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    Mlp84B Muscle LIM protein at 84B [ Drosophila melanogaster ]

    Gene ID: 40849, updated on 10-May-2012
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    Summary

    Official Symbol
    Mlp84Bprovided by Flybase
    Official Full Name
    Muscle LIM protein at 84Bprovided by Flybase
    Primary source
    FLYBASE:FBgn0014863
    Locus tag
    Dmel_CG1019
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1019; DLim-3; Dmel\CG1019; DmLIM-3; dMlp84B; Mlmu84B; mlp; mlp84B; Mlp84b
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    Genomic context

    Location :
    84C1-84C1
    Sequence :
    Chromosome: 3R; NT_033777.2 (2939244..2943453, complement)
    See Mlp84B in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene alpha-Tubulin at 84B Neighboring gene enhancer of yellow 2b Neighboring gene Alhambra Neighboring gene CG10098 gene product from transcript CG10098-RA Neighboring gene CG10068 gene product from transcript CG10068-RA Neighboring gene ncRNA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Deletion of Drosophila muscle LIM protein decreases flight muscle stiffness and power generation. Clark KA, et al. Am J Physiol Cell Physiol, 2011 Aug. PMID 21562304.
    2. The role of Drosophila Lamin C in muscle function and gene expression. Dialynas G, et al. Development, 2010 Sep. PMID 20702563.
    3. Detection of transgenerational spermatogenic inheritance of adult male acquired CNS gene expression characteristics using a Drosophila systems model. Sharma A, et al. PLoS One, 2009 Jun 2. PMID 19503609.
    4. A systematic analysis of Tinman function reveals Eya and JAK-STAT signaling as essential regulators of muscle development. Liu YH, et al. Dev Cell, 2009 Feb. PMID 19217429.
    5. Tissue remodeling: a mating-induced differentiation program for the Drosophila oviduct. Kapelnikov A, et al. BMC Dev Biol, 2008 Dec 8. PMID 19063748.

    See all (29) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data suggest mlp84B contributes to wing muscle stiffness and is necessary for maximum work and power generation.
      Title: Deletion of Drosophila muscle LIM protein decreases flight muscle stiffness and power generation.
    2. These data demonstrate that Mlp84B is essential for normal cardiac function.
      Title: The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function.
    3. Results reveal a role for Mlp84B in maintaining muscle structural integrity, and suggest Mlp84B and D-titin cooperate to stabilize muscle sarcomeres.
      Title: The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:66046 BioGRID:60073 CG11015    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:58700 CG11164    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:63131 CG13501    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:67678 CG13830    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:58328 CG17440    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:58199 CG2258    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:61344 CG31624    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:78197 CG41099    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:60452 CG5708    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:67606 CG7046    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:59306 CG9572    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:57951 Cdk7    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:69948 ImpE1    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:65188 Lmpt    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:61888 Pfk    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:58527 PhKgamma    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:65737 Ssl1    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:60511 TfIIB    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:58951 Traf-like    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:61267 nesd    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:76307 nimB2    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:60845 nimC1    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:61701 ptc    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:64015 slow    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:66180 stck    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:66338 trbd    BioGRID  PubMed Two-hybrid 
    BioGRID:66046 BioGRID:61139 tup    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the Mlp84B gene: The Mlp84B gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, and C.elegans.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    structural constituent of muscle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    structural constituent of muscle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell differentiation NAS
    Non-traceable Author Statement
    more info
    		  
    muscle tissue development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    sarcomere organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    skeletal muscle tissue development NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm NAS
    Non-traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CG1019 gene product from transcript CG1019-RA
    Names
    CG1019-PA
    CG1019-PB
    Mlp84B-PA
    Mlp84B-PB
    Muscle-specific LIM protein at 84B
    muscle LIM protein at 84B
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      2939244..2943453, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057774.4 → NP_477122.1  muscle LIM protein at 84B, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V2J1
      UniProtKB/Swiss-Prot
      Q24400
      Related
      FBpp0081133, FBtr0081616
      Conserved Domains (2) summary
      cd09326
      Location:421 – 474
      Blast Score: 208
      LIM_CRP_like; The LIM domains of Cysteine Rich Protein (CRP) family
      cd09404
      Location:11 – 64
      Blast Score: 259
      LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A

    2. NM_169173.2 → NP_731134.1  muscle LIM protein at 84B, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V2J1
      UniProtKB/Swiss-Prot
      Q24400
      Related
      FBpp0081134, FBtr0081617
      Conserved Domains (2) summary
      cd09326
      Location:421 – 474
      Blast Score: 208
      LIM_CRP_like; The LIM domains of Cysteine Rich Protein (CRP) family
      cd09404
      Location:11 – 64
      Blast Score: 259
      LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA BT003202.1 AAO24957.1
    genomic AE014297.2 AAF54063.1
    genomic AF090832.1 AAC61591.1
    mRNA X91245.1 CAA62627.1
    genomic AE014297.2 AAF54064.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24400.1 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content