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    Antp Antennapedia [ Drosophila melanogaster ]

    Gene ID: 40835, updated on 10-May-2012
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    Summary

    Official Symbol
    Antpprovided by Flybase
    Official Full Name
    Antennapediaprovided by Flybase
    Primary source
    FLYBASE:FBgn0260642
    Locus tag
    Dmel_CG1028
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    3.4; Ant; ANT-C; ANT-P; ANTC; antp; AntP; ANTP; Antp P1; Antp P2; Antp1; AntP1; Aus; BG:DS07700.1; CG1028; DmAntp; DMANTPE1; Dmel\CG1028; DRO15DC96Z; Hu; l(3)84Ba; Ns; Scx
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    Genomic context

    Location :
    84A6-84B2; 3-47.5 cM
    Sequence :
    Chromosome: 3R; NT_033777.2 (2721975..2824950, complement)
    See Antp in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene Sex combs reduced Neighboring gene fushi tarazu Neighboring gene CG43252 gene product from transcript CG43252-RA Neighboring gene Sorbitol dehydrogenase 1 Neighboring gene CG1979 gene product from transcript CG1979-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Functional synthetic Antennapedia genes and the dual roles of YPWM motif and linker size in transcriptional activation and repression. Papadopoulos DK, et al. Proc Natl Acad Sci U S A, 2011 Jul 19. PMID 21712439.
    2. Segment-specific regulation of the Drosophila AP-2 gene during leg and antennal development. Ahn Y, et al. Dev Biol, 2011 Jul 15. PMID 21575621.
    3. Genome-wide analysis of the binding of the Hox protein Ultrabithorax and the Hox cofactor Homothorax in Drosophila. Choo SW, et al. PLoS One, 2011 Apr 5. PMID 21483667.
    4. Interactions among Polycomb domains are guided by chromosome architecture. Tolhuis B, et al. PLoS Genet, 2011 Mar. PMID 21455484.
    5. Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila. Bantignies F, et al. Cell, 2011 Jan 21. PMID 21241892.

    See all (565) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Functional synthetic Antennapedia genes and the YPWM motif play dual roles in transcriptional activation and repression.
      Title: Functional synthetic Antennapedia genes and the dual roles of YPWM motif and linker size in transcriptional activation and repression.
    2. The function of Antennapedia in the leg is not to repress homothorax, as has been suggested, but to directly repress spineless and other antennal genes that would otherwise be activated within this ring.
      Title: Control of the spineless antennal enhancer: direct repression of antennal target genes by Antennapedia.
    3. N-tail of Antp also improves the binding affinity for DNA, with a major contribution by the released waters.
      Title: Disordered tails of homeodomains facilitate DNA recognition by providing a trade-off between folding and specific binding.
    4. Antagonistic roles for ubx and Antp in regulating segment-specific apoptosis of differentiated motoneurons in the Drosophila embryionic central nervous system are reported.
      Title: Antagonistic roles for Ultrabithorax and Antennapedia in regulating segment-specific apoptosis of differentiated motoneurons in the Drosophila embryonic central nervous system.
    5. homeodomain supports multiple molecular regulatory functions in addition to protein-DNA and protein-RNA interactions
      Title: Cross-regulatory protein-protein interactions between Hox and Pax transcription factors.
    6. BIP2 binds with the YPWM motif of ANTP in vitro, as well as in vivo, transforming eye to wing tissue.
      Title: The YPWM motif links Antennapedia to the basal transcriptional machinery.
    7. Temporal and dosage relationships are more subtle than suspected and must be part of a robust understanding of molecular network behaviour involved in determining appendage identity in Drosophila melanogaster.
      Title: Complex genetic interactions govern the temporal effects of Antennapedia on antenna-to-leg transformations in Drosophila melanogaster.
    8. The Antennapedia-derived cell-penetating peptide penetratin can translocate through lipid bilayers by a potential- and composition-dependent pathway that causes only minimal perturbation to the overall integrity and barrier function of the bilayer.
      Title: Penetratin and related cell-penetrating cationic peptides can translocate across lipid bilayers in the presence of a transbilayer potential.
    9. identified new cis-regulatory DNAs in the approximately 50-kb Scr-Antp interval
      Title: Long-range enhancer-promoter interactions in the Scr-Antp interval of the Drosophila Antennapedia complex.
    10. Temporal and spatial regulation of the homeotic selector gene Antennapedia in the leg disc is necessary for normal leg development in Drosophila.
      Title: Spatial and temporal regulation of the homeotic selector gene Antennapedia is required for the establishment of leg identity in Drosophila.
    Submit: New GeneRIF Correction See all (15)
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:66033 BioGRID:62906 CG15120    BioGRID  PubMed Two-hybrid 
    BioGRID:66033 BioGRID:63828 CG16985    BioGRID  PubMed Two-hybrid 
    BioGRID:66033 BioGRID:64065 CG4623    BioGRID  PubMed Two-hybrid 
    BioGRID:66033 BioGRID:65193 Cpr73D    BioGRID  PubMed Two-hybrid 
    BioGRID:66033 BioGRID:60939 CycE    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:66033 BioGRID:66030 Dfd    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:66033 BioGRID:72866 Dsp1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:66033 BioGRID:65606 Pc    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:66033 BioGRID:62752 Pcl    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:66033 BioGRID:66031 Scr    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:66033 BioGRID:65866 Snr1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:66033 BioGRID:67078 Ubx    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:66033 BioGRID:64396 Zasp66    BioGRID  PubMed Two-hybrid 
    BioGRID:66033 BioGRID:67862 ash2    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:66033 BioGRID:65055 brm    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:66033 BioGRID:60299 d    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:66033 BioGRID:68643 ey    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:66033 BioGRID:66419 hth    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:66033 BioGRID:66015 lab    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:66033 BioGRID:66996 mor    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:66033 BioGRID:67162 osa    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:66033 BioGRID:68897 spen    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:66033 BioGRID:64594 tna    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:66033 BioGRID:66813 trx    BioGRID  PubMed Phenotypic Suppression 
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    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		  
    sequence-specific DNA binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		  
    sequence-specific distal enhancer binding RNA polymerase II transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    heart development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    lymph gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    midgut development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    neuroblast development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of transcription from RNA polymerase II promoter NAS
    Non-traceable Author Statement
    more info
    		  
    segment specification NAS
    Non-traceable Author Statement
    more info
    		  
    specification of segmental identity, antennal segment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CG1028 gene product from transcript CG1028-RG
    Names
    Antp-PD
    Antp-PE
    Antp-PF
    Antp-PG
    Antp-PH
    Antp-PI
    Antp-PJ
    Antp-PK
    Antp-PL
    Antp-PM
    Antp-PN
    Aus
    CG1028-PD
    CG1028-PE
    CG1028-PF
    CG1028-PG
    CG1028-PH
    CG1028-PI
    CG1028-PJ
    CG1028-PK
    CG1028-PL
    CG1028-PM
    CG1028-PN
    Dm-Antennapedia
    Sex comb extra
    Sex combs extra
    antenapedia
    antennapaedia
    antennapedia
    antennapedia P1
    antennapedia P2
    humeral
    nasobemia
    NP_996167.1
    • unusual splice
    NP_996168.1
    • unusual splice
    NP_996169.1
    • unusual splice
    NP_996170.1
    • unusual splice
    NP_996172.1
    • unusual splice
    NP_996175.1
    • unusual splice
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      2721975..2824950, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206451.1 → NP_996173.1  antennapedia, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSY7
      Related
      FBpp0089242, FBtr0081649
      Conserved Domains (1) summary
      cd00086
      Location:281 – 339
      Blast Score: 211
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    2. NM_206450.1 → NP_996172.1  antennapedia, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSY6
      Related
      FBpp0089243, FBtr0081650
      Conserved Domains (1) summary
      cd00086
      Location:285 – 343
      Blast Score: 211
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    3. NM_206449.1 → NP_996171.1  antennapedia, isoform N [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSY5
      Related
      FBpp0089086, FBtr0081651
      Conserved Domains (1) summary
      cd00086
      Location:294 – 352
      Blast Score: 215
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    4. NM_206453.1 → NP_996175.1  antennapedia, isoform M [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V2I6
      UniProtKB/Swiss-Prot
      P02833
      Related
      FBpp0081161, FBtr0081647
      Conserved Domains (1) summary
      cd00086
      Location:298 – 356
      Blast Score: 215
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    5. NM_206444.1 → NP_996166.1  antennapedia, isoform K [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSY7
      Related
      FBpp0089247, FBtr0081656
      Conserved Domains (1) summary
      cd00086
      Location:281 – 339
      Blast Score: 211
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    6. NM_206447.1 → NP_996169.1  antennapedia, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSY6
      Related
      FBpp0089244, FBtr0081653
      Conserved Domains (1) summary
      cd00086
      Location:285 – 343
      Blast Score: 211
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    7. NM_206452.1 → NP_996174.1  antennapedia, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSY5
      Related
      FBpp0089241, FBtr0081648
      Conserved Domains (1) summary
      cd00086
      Location:294 – 352
      Blast Score: 215
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    8. NM_206448.1 → NP_996170.1  antennapedia, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V2I6
      UniProtKB/Swiss-Prot
      P02833
      Related
      FBpp0081162, FBtr0081652
      Conserved Domains (1) summary
      cd00086
      Location:298 – 356
      Blast Score: 215
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    9. NM_206446.1 → NP_996168.1  antennapedia, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V2I6
      UniProtKB/Swiss-Prot
      P02833
      Related
      FBpp0089245, FBtr0081654
      Conserved Domains (1) summary
      cd00086
      Location:298 – 356
      Blast Score: 215
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    10. NM_206445.1 → NP_996167.1  antennapedia, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V2I6
      UniProtKB/Swiss-Prot
      P02833
      Related
      FBpp0089246, FBtr0081655
      Conserved Domains (1) summary
      cd00086
      Location:298 – 356
      Blast Score: 215
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    11. NM_206454.1 → NP_996176.1  antennapedia, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P02833
      Related
      FBpp0081160, FBtr0081646
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014297.2 AAS65106.1
    genomic AE014297.2 AAS65105.1
    genomic AE014297.2 AAS65107.1
    genomic AE014297.2 AAS65108.1
    genomic AE014297.2 AAS65110.1
    genomic AE014297.2 AAS65109.1
    genomic AE001572.2 AAD19793.1
    genomic AE014297.2 AAS65113.1
    mRNA M20705.1 AAA70216.1
    mRNA M20704.1 AAA70214.1
    genomic AE014297.2 AAS65114.1
    genomic AE014297.2 AAS65112.1
    genomic AE014297.2 AAS65111.1
    genomic AE014297.2 AAG22205.3
    mRNA AY060407.1 AAL25446.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KSY7.1 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content