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Btnl3 butyrophilin-like 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 407781, updated on 29-Feb-2024

Summary

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Official Symbol
Btnl3provided by RGD
Official Full Name
butyrophilin-like 3provided by RGD
Primary source
RGD:1303262
See related
Ensembl:ENSRNOG00000039396 AllianceGenome:RGD:1303262
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Btnl1
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Orthologous to human BTNL3 (butyrophilin like 3); BTNL8 (butyrophilin like 8); and BTN3A3 (butyrophilin subfamily 3 member A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 2.2), Testes (RPKM 1.6) and 5 other tissues See more
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Genomic context

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Location:
20p12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4475984..4490955, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4474056..4489024, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4156858..4171887)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene butyrophilin, subfamily 3, member A2 Neighboring gene uncharacterized LOC134483778 Neighboring gene testis expressed basic protein 1 Neighboring gene uncharacterized LOC108349035 Neighboring gene butyrophilin-like 2 Neighboring gene RT1 class II, locus Da

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extrathymic T cell selection IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
butyrophilin-like protein 1
Names
butyrophilin-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002803.2 → NP_001002803.2  butyrophilin-like protein 1

    Status: INFERRED

    Source sequence(s)
    BX883043
    UniProtKB/TrEMBL
    A0A8I6B1V5, F7FDE0
    Related
    ENSRNOP00000029848.5, ENSRNOT00000039553.7
    Conserved Domains (4) summary
    cd05713
    Location:46 → 144
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:39 → 144
    IG_like; Immunoglobulin like
    pfam03879
    Location:271 → 311
    Cgr1; Cgr1 family
    cl02614
    Location:377 → 492
    SPRY; SPRY domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    4475984..4490955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279384.1 → XP_063135454.1  butyrophilin-like protein 1 isoform X2

  2. XM_017601723.3 → XP_017457212.1  butyrophilin-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6B1V5
    Related
    ENSRNOP00000095027.1

  3. XM_063279385.1 → XP_063135455.1  butyrophilin-like protein 1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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