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    Rm62 [ Drosophila melanogaster ]

    Gene ID: 40739, updated on 11-May-2012
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    Summary

    Official Symbol
    Rm62provided by Flybase
    Primary source
    FLYBASE:FBgn0003261
    Locus tag
    Dmel_CG10279
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4136; CG10279; Dmel\CG10279; dmP68; Dmp68; DmRH8; l(3)01086; l(3)j3D2; l(3)j3D5; l(3)rG338; l(3)s5196; Lip; p68; rm62; RM62
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    Genomic context

    Location :
    83D1-83D2
    Sequence :
    Chromosome: 3R; NT_033777.2 (1826148..1834301, complement)
    See Rm62 in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene Pheromone-binding protein-related protein 3 Neighboring gene Olfactory-specific E Neighboring gene CG10280 gene product from transcript CG10280-RA Neighboring gene CG11459 gene product from transcript CG11459-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The RNA helicase Rm62 cooperates with SU(VAR)3-9 to re-silence active transcription in Drosophila melanogaster. Boeke J, et al. PLoS One, 2011. PMID 21674064.
    2. Nuclear accumulation of stress response mRNAs contributes to the neurodegeneration caused by Fragile X premutation rCGG repeats. Qurashi A, et al. PLoS Genet, 2011 Jun. PMID 21655086.
    3. Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis. Gerbasi VR, et al. Proc Natl Acad Sci U S A, 2011 Feb 22. PMID 21300896.
    4. A novel strategy to isolate ubiquitin conjugates reveals wide role for ubiquitination during neural development. Franco M, et al. Mol Cell Proteomics, 2011 May. PMID 20861518.
    5. Perturbation analysis of heterochromatin-mediated gene silencing and somatic inheritance. Schneiderman JI, et al. PLoS Genet, 2010 Sep 9. PMID 20838586.

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. RNA helicase interacts with the well-characterized histone methyltransferase SU(VAR)3-9 via its N-terminus, which provides a potential mechanism for the targeting of H3K9 methylation to highly regulated genes.
      Title: The RNA helicase Rm62 cooperates with SU(VAR)3-9 to re-silence active transcription in Drosophila melanogaster.
    2. Rm62, a DEAD-box RNA helicase, complexes with DSP1 in Drosophila embryos
      Title: Rm62, a DEAD-box RNA helicase, complexes with DSP1 in Drosophila embryos.
    3. have isolated a dFMR1-associated complex that includes two ribosomal proteins, L5 and L11, along with 5S RNA. The dFMR1 complex also contains Argonaute2 (AGO2) and a Drosophila homolog of p68 RNA helicase (Dmp68)
      Title: A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:65943 BioGRID:65002 AGO2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:65943 BioGRID:58952 Anxb11    BioGRID  PubMed Two-hybrid 
    BioGRID:65943 BioGRID:58295 Bx42    BioGRID  PubMed Two-hybrid 
    BioGRID:65943 BioGRID:67510 C15    BioGRID  PubMed Two-hybrid 
    BioGRID:65943 BioGRID:62123 CG13155    BioGRID  PubMed Two-hybrid 
    BioGRID:65943 BioGRID:59269 CG14216    BioGRID  PubMed Two-hybrid 
    BioGRID:65943 BioGRID:61051 CG5110    BioGRID  PubMed Two-hybrid 
    BioGRID:65943 BioGRID:62692 CG6459    BioGRID  PubMed Two-hybrid 
    BioGRID:65943 BioGRID:63721 CG7879    BioGRID  PubMed Two-hybrid 
    BioGRID:65943 BioGRID:59713 CG8813    BioGRID  PubMed Two-hybrid 
    BioGRID:65943 BioGRID:65121 Cpr72Ea    BioGRID  PubMed Two-hybrid 
    BioGRID:65943 BioGRID:63147 Fmr1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:65943 BioGRID:63571 Nplp1    BioGRID  PubMed Two-hybrid 
    BioGRID:65943 BioGRID:65943 Rm62    BioGRID  PubMed Two-hybrid 
    BioGRID:65943 BioGRID:58951 Traf-like    BioGRID  PubMed Two-hybrid 
    BioGRID:65943 BioGRID:67795 Tsc1    BioGRID  PubMed Two-hybrid 
    BioGRID:65943 BioGRID:63592 mri    BioGRID  PubMed Two-hybrid 
    BioGRID:65943 BioGRID:60366 numb    BioGRID  PubMed Two-hybrid 
    BioGRID:65943 BioGRID:68723 prc    BioGRID  PubMed Two-hybrid 
    BioGRID:65943 BioGRID:62424 row    BioGRID  PubMed Two-hybrid 
    BioGRID:65943 BioGRID:59774 sec5    BioGRID  PubMed Two-hybrid 
    BioGRID:65943 BioGRID:63369 usnp    BioGRID  PubMed Two-hybrid 
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    General gene information

    Pathways from BioSystems

    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ATP-dependent RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    ATP-dependent RNA helicase activity NAS
    Non-traceable Author Statement
    more info
    		  
    mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    RNA interference IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    antimicrobial humoral response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		  
    nuclear mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    regulation of alternative nuclear mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		  
    polytene chromosome puff IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    precatalytic spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG10279 gene product from transcript CG10279-RK
    Names
    CG10279-PA
    CG10279-PB
    CG10279-PC
    CG10279-PD
    CG10279-PE
    CG10279-PF
    CG10279-PH
    CG10279-PI
    CG10279-PJ
    CG10279-PK
    CG10279-PL
    CG10279-PM
    Lighten-up
    Rm62
    Rm62-PA
    Rm62-PB
    Rm62-PC
    Rm62-PD
    Rm62-PE
    Rm62-PF
    Rm62-PH
    Rm62-PI
    Rm62-PJ
    Rm62-PK
    Rm62-PL
    Rm62-PM
    lighten up
    NP_001163528.1
    NP_001189182.1
    NP_001246938.1
    NP_001246939.1
    NP_001246940.1
    NP_001246941.1
    NP_524243.2
    NP_731031.1
    NP_731032.1
    NP_731033.1
    NP_731034.1
    NP_731035.2
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      1826148..1834301, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260010.1 → NP_001246939.1  Rm62, isoform K [Drosophila melanogaster]

      Status: REVIEWED

    2. NM_001202253.2 → NP_001189182.1  Rm62, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAE4
      UniProtKB/Swiss-Prot
      P19109
      Conserved Domains (3) summary
      cd00268
      Location:142 – 347
      Blast Score: 732
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      cd00079
      Location:358 – 492
      Blast Score: 341
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      PTZ00424
      Location:139 – 515
      Blast Score: 597
      PTZ00424; helicase 45; Provisional

    3. NM_001260012.1 → NP_001246941.1  Rm62, isoform M [Drosophila melanogaster]

      Status: REVIEWED

    4. NM_001260009.1 → NP_001246938.1  Rm62, isoform J [Drosophila melanogaster]

      Status: REVIEWED

    5. NM_169118.1 → NP_731031.1  Rm62, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJ68
      UniProtKB/Swiss-Prot
      P19109
      Related
      FBpp0078299, FBtr0078650
      Conserved Domains (3) summary
      cd00268
      Location:139 – 344
      Blast Score: 733
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      cd00079
      Location:355 – 489
      Blast Score: 341
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      PTZ00424
      Location:136 – 512
      Blast Score: 597
      PTZ00424; helicase 45; Provisional

    6. NM_001260011.1 → NP_001246940.1  Rm62, isoform L [Drosophila melanogaster]

      Status: REVIEWED

    7. NM_169120.1 → NP_731033.1  Rm62, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P19109
      Related
      FBpp0078298, FBtr0078649
      Conserved Domains (3) summary
      cd00268
      Location:142 – 347
      Blast Score: 731
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      cd00079
      Location:358 – 492
      Blast Score: 342
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      PTZ00424
      Location:139 – 515
      Blast Score: 596
      PTZ00424; helicase 45; Provisional

    8. NM_001170057.1 → NP_001163528.1  Rm62, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJ68
      UniProtKB/Swiss-Prot
      P19109
      Related
      FBpp0291159, FBtr0301947
      Conserved Domains (3) summary
      cd00268
      Location:139 – 344
      Blast Score: 733
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      cd00079
      Location:355 – 489
      Blast Score: 341
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      PTZ00424
      Location:136 – 512
      Blast Score: 597
      PTZ00424; helicase 45; Provisional

    9. NM_079519.2 → NP_524243.2  Rm62, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P19109
      Related
      FBpp0078301, FBtr0078652
      Conserved Domains (3) summary
      cd00268
      Location:283 – 488
      Blast Score: 733
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      cd00079
      Location:499 – 633
      Blast Score: 343
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      PTZ00424
      Location:280 – 656
      Blast Score: 597
      PTZ00424; helicase 45; Provisional

    10. NM_169122.1 → NP_731035.2  Rm62, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P19109
      Related
      FBpp0078300, FBtr0078651
      Conserved Domains (3) summary
      cd00268
      Location:142 – 347
      Blast Score: 731
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      cd00079
      Location:358 – 492
      Blast Score: 342
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      PTZ00424
      Location:139 – 515
      Blast Score: 596
      PTZ00424; helicase 45; Provisional

    11. NM_169119.3 → NP_731032.1  Rm62, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAE4
      UniProtKB/Swiss-Prot
      P19109
      Related
      FBpp0078302
      Conserved Domains (3) summary
      cd00268
      Location:142 – 347
      Blast Score: 732
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      cd00079
      Location:358 – 492
      Blast Score: 341
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      PTZ00424
      Location:139 – 515
      Blast Score: 597
      PTZ00424; helicase 45; Provisional

    12. NM_169121.1 → NP_731034.1  Rm62, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P19109
      Related
      FBpp0078303, FBtr0078654
      Conserved Domains (3) summary
      cd00268
      Location:142 – 347
      Blast Score: 731
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      cd00079
      Location:358 – 492
      Blast Score: 342
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      PTZ00424
      Location:139 – 515
      Blast Score: 596
      PTZ00424; helicase 45; Provisional
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014297.2 AFH06258.1
    genomic AE014297.2 ADV37273.1
    genomic AE014297.2 AAF51927.2
    mRNA BT099694.1 ACV53058.1
    genomic AE014297.2 AFH06260.1
    genomic AE014297.2 AFH06257.1
    genomic AE014297.2 ACZ94826.1
    mRNA BT015209.1 AAT94438.1
    genomic AE014297.2 AAN14331.1
    genomic AE014297.2 AFH06259.1
    genomic HC746255.1 CBM36361.1
    genomic AE014297.2 AAN14332.1
    mRNA BT001716.1 AAN71471.1
    genomic AE014297.2 AAG22212.1
    genomic AE014297.2 AAF51926.2
    genomic HC746441.1 CBM36454.1
    mRNA BT011476.1 AAR99134.1
    genomic AE014297.2 AAG22213.2
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AWN9.1 GenPept
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    Additional Links

    Gene LinkOut

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