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Sec20 Secretory 20 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40724, updated on 4-Apr-2024

Summary

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Official Symbol
Sec20provided by FlyBase
Official Full Name
Secretory 20provided by FlyBase
Primary source
FLYBASE:FBgn0037383
Locus tag
Dmel_CG2023
See related
AllianceGenome:FB:FBgn0037383
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cg2023; CG2023; Dmel\CG2023; lincRNA.683
Summary
Predicted to enable SNAP receptor activity. Involved in regulation of autophagy and regulation of vesicle-mediated transport. Predicted to be part of SNARE complex. Predicted to be active in endoplasmic reticulum. Is expressed in adult head and adult heart. Orthologous to human BNIP1 (BCL2 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Sec20 in Genome Data Viewer
Location:
83C4-83C4; 3-47.5 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5822026..5824532, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1647748..1650254, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Hpr1 Neighboring gene uncharacterized protein Neighboring gene degringolade Neighboring gene globin 3 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sec20 is Required for Autophagic and Endocytic Degradation Independent of Golgi-ER Retrograde Transport. Lakatos Z, et al. Cells, 2019 Jul 24. PMID 31344970, Free PMC Article
  2. Comparative genomic analysis of multi-subunit tethering complexes demonstrates an ancient pan-eukaryotic complement and sculpting in Apicomplexa. Klinger CM, et al. PLoS One, 2013. PMID 24086721, Free PMC Article
  3. Misexpression screen in Drosophila melanogaster aiming to reveal novel factors involved in formation of body parts. Grieder NC, et al. Genetics, 2007 Apr. PMID 17179072, Free PMC Article
  4. RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway. Asensio CS, et al. J Cell Biol, 2010 Dec 13. PMID 21149569, Free PMC Article
  5. SNAREing the basis of multicellularity: consequences of protein family expansion during evolution. Kloepper TH, et al. Mol Biol Evol, 2008 Sep. PMID 18621745

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c5823541-5822435 mobile_element_type = transposon:1360{}1226

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables SNAP receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum membrane fusion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
secretory 20
Names
CG2023-PA
CG2023-PB
Sec20-PA
Sec20-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5822026..5824532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141338.3 → NP_649595.1  secretory 20, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649595.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNI9
    Related
    FBpp0078315
    Conserved Domains (1) summary
    pfam03908
    Location:135 → 226
    Sec20; Sec20

  2. NM_001300258.1 → NP_001287187.1  secretory 20, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287187.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNI9
    Conserved Domains (1) summary
    pfam03908
    Location:135 → 226
    Sec20; Sec20
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VNI9 Q9VNI9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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