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EPCAM epithelial cell adhesion molecule [ Homo sapiens (human) ]

Gene ID: 4072, updated on 21-Jul-2014
Official Symbol
EPCAMprovided by HGNC
Official Full Name
epithelial cell adhesion moleculeprovided by HGNC
Primary source
HGNC:11529
See related
Ensembl:ENSG00000119888; HPRD:01709; MIM:185535; Vega:OTTHUMG00000128853
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1
Summary
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
See EPCAM in Epigenomics, MapViewer
Location:
2p21
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (47369148..47387028)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (47596287..47614167)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927043 Neighboring gene calmodulin 2 (phosphorylase kinase, delta) Neighboring gene brain cytoplasmic RNA 1 Neighboring gene microRNA 559 Neighboring gene mutS homolog 2 Neighboring gene potassium channel, subfamily K, member 12

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • GA733-2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
tight junction IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
epithelial cell adhesion molecule
Names
epithelial cell adhesion molecule
epithelial glycoprotein 314
human epithelial glycoprotein-2
cell surface glycoprotein Trop-1
adenocarcinoma-associated antigen
tumor-associated calcium signal transducer 1
major gastrointestinal tumor-associated protein GA733-2
membrane component, chromosome 4, surface marker (35kD glycoprotein)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012352.2 

    Range
    28986..46866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_215

mRNA and Protein(s)

  1. NM_002354.2NP_002345.2  epithelial cell adhesion molecule precursor

    See proteins identical to NP_002345.2

    Status: REVIEWED

    Source sequence(s)
    AW050533, BC014785, BP262680, DA963872, DB044092
    Consensus CDS
    CCDS1833.1
    UniProtKB/Swiss-Prot
    P16422
    Related
    ENSP00000263735, OTTHUMP00000159073, ENST00000263735, OTTHUMT00000250792
    Conserved Domains (1) summary
    cd00191
    Location:65125
    Blast Score: 151
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 

    Range
    47369148..47387028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000134.1 

    Range
    47332819..47350813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 

    Range
    47526380..47544227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)