FASLG Fas ligand [Bos taurus (cattle)] - Gene

Summary

Official Symbol: FASLGprovided by VGNC
Official Full Name: Fas ligandprovided by VGNC
Primary source: VGNC:VGNC:28870
See related: BGD:BT11771; Ensembl:ENSBTAG00000032808
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	16	NC_037343.1 (40161402..40169422)

Chromosome 16 - NC_037343.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It was concluded that the Fas-FasL signaling pathway was involved in regulation of bovine oocyte apoptosis, perhaps related to B cell lymphoma/leukemia-2 associated X upregulation.
Title: FasL-induced apoptosis in bovine oocytes via the Bax signal.
activation of the Fas pathway and presence of FSH during in vitro maturation increased the incidence of apoptosis in cumulus cells
Title: Role of Fas-mediated apoptosis and follicle-stimulating hormone on the developmental capacity of bovine cumulus oocyte complexes in vitro.

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General gene information

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Markers

IDVGA-49 (e-PCR), detects polymorphism
- UniSTS:251458

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor ligand superfamily member 6

Names: APO-1 ligand; CD95 ligand; TNF superfamily, member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098859.2 → NP_001092329.1 tumor necrosis factor ligand superfamily member 6

See identical proteins and their annotated locations for NP_001092329.1

Status: PROVISIONAL

Source sequence(s)

BC146056

UniProtKB/TrEMBL

A6H6Z6, G9HQC2

Related

ENSBTAP00000043860.3, ENSBTAT00000046575.4

Conserved Domains (1) summary

cd00184
Location:142 → 275

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...