MIR33A microRNA 33a [Homo sapiens (human)] - Gene

Summary

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Official Symbol: MIR33Aprovided by HGNC
Official Full Name: microRNA 33aprovided by HGNC
Primary source: HGNC:31634
See related: MIM:612156; miRBase:MI0000091
Gene type: miscRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIR33; MIRN33; miR-33; MIRN33A; miRNA33A; hsa-mir-33; hsa-mir-33a
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Genomic context

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Location :: 22q13.2

Sequence :: Chromosome: 22; NC_000022.10 (42296948..42297016)

See MIR33A in Epigenomics, MapViewer

Chromosome 22 - NC_000022.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

The miR-33 regulates post-transcriptional CDK6 and CCND1 expression.
Title: Mir-33 regulates cell proliferation and cell cycle progression.
After epithelial-mesenchymal transition, miR-33a and mir-193a were downregulated in A549 cells.
Title: [Epithelial-mesenchymal transition (EMT) and its effect on microRNA expression in lung cancer].
Data show that miR-33a has potential tumor suppressor activity, acting through inhibition of Pim-1.
Title: The proto-oncogene Pim-1 is a target of miR-33a.
Inhibition of miR-33a expression in apolipoprotein E knockout islets and ABCA1 overexpression in beta-cell-specific ABCA1 knockout islets rescued normal insulin secretion and reduced islet cholesterol
Title: miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets.
miR-33a and -b regulate pathways controlling three of the risk factors of metabolic syndrome: levels of HDL, triglycerides, and insulin signaling
Title: miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling.
miR-33 expression from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation
Title: Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation.
Data show that miR-33 is encoded within SREBP-2 and that both mRNAs are coexpressed.
Title: miR-33 links SREBP-2 induction to repression of sterol transporters.
miR-33a/b embedded within introns of SREBP genes targets ABCA1, a regulator of HDL synthesis and reverse cholesterol transport, for posttranscriptional repression; indicates miR-33 acts in concert with SREBP host genes to control cholesterol homeostasis
Title: MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Pathways from BioSystems

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Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystem (from WikiPathways)
Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystemNuclear receptors are transcription factors that are activated upon binding to its ligands. Initially, they had been classified as classic endocrine nuclear hormone receptors and orphan receptors. Ho...
SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystem (from WikiPathways)
SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystemThis pathway describes transcription factor-microRNA circuits governing cholesterol and lipid homeostasis. It is based on a seminar by Dr. Anders N??r.
SREBP signalling, organism-specific biosystem (from WikiPathways)
SREBP signalling, organism-specific biosystemSterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcript...
Statin Pathway, organism-specific biosystem (from WikiPathways)
Statin Pathway, organism-specific biosystemStatins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in...

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

NR_029507.1 RNA Sequence

Status: PROVISIONAL

Source sequence(s)

Z99716

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000022.10 Reference GRCh37.p10 Primary Assembly

Range

42296948..42297016

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000154.1 Alternate HuRef

Range

25262647..25262715

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018933.1 Alternate CHM1_1.0

Range

26213055..26213123

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GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01055655.1 (48509..48577)	None
genomic	AMYH01012804.1 (252872..252940)	None
genomic	Z99716.4 (44184..44252)	None
mRNA	AJ421755.1	None