ARR3 arrestin 3, retinal (X-arrestin) [Homo sapiens] - Gene

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Summary

Official Symbol: ARR3provided by HGNC
Official Full Name: arrestin 3, retinal (X-arrestin)provided by HGNC
Primary source: HGNC:710
Locus tag: RP13-26D14.6
See related: Ensembl:ENSG00000120500; HPRD:02358; MIM:301770; Vega:OTTHUMG00000021768
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ARRX

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Genomic context

Location :: Xcen-q21

Sequence :: Chromosome: X; NC_000023.10 (69488185..69501690)

See ARR3 in Epigenomics, MapViewer

Chromosome X - NC_000023.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PP2A inhibits association between the Na+,K+-ATPase and arrestin, and diminishes the effect of arrestin on Na+,K+-ATPase trafficking.
Title: Protein phosphatase 2A interacts with the Na,K-ATPase and modulates its trafficking by inhibition of its association with arrestin.
upon ligand activation, CysLT(1)R is tyrosine-phosphorylated and released from heterodimers with CysLT(2)R and, subsequently, internalizes from the plasma membrane to the nuclear membrane in a clathrin-, arrestin-3-, and Rab-5-dependent manner
Title: Ligand-induced tyrosine phosphorylation of cysteinyl leukotriene receptor 1 triggers internalization and signaling in intestinal epithelial cells.
The agonist-induced internalization of GPR109A receptors is regulated by GRK2 and arrestin3 in a pertussis toxin-sensitive manner and that internalized receptor recycling is independent of endosomal acidification.
Title: Internalization of the human nicotinic acid receptor GPR109A is regulated by G(i), GRK2, and arrestin3.
two non-visual arrestins, arrestin2 and arrestin3, localize to the centrosome, a key organelle involved in microtubule nucleation and bipolar mitotic spindle assembly
Title: Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function.
the molecular interactions of arrestin2 and arrestin3 and their individual domains with the components of the two MAPK cascades, ASK1-MKK4-JNK3 and c-Raf-1-MEK1-ERK2
Title: How does arrestin assemble MAPKs into a signaling complex?
Arrestin 3 but not arrestin 2 is required for internalization of C-C chemokine receptor CCR7 when bound to C-C chemokine ligand CCL19. In contrast, arrestins are not required for internalization of CCR7/CCL21.
Title: Arrestin 3 mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21.
The light-dependent translocation of cone arrestin suggests a role in light-dark adaptation of cones.
Title: Identification and light-dependent translocation of a cone-specific antigen, cone arrestin, recognized by monoclonal antibody 7G6.
Arrestin in all conformations binds JNK3 comparably, whereas Mdm2 preferentially binds cone arrestin 'frozen' in the basal state.
Title: Cone arrestin binding to JNK3 and Mdm2: conformational preference and localization of interaction sites.
Regulation of arrestin-3 phosphorylation by casein kinase II.
Title: Regulation of arrestin-3 phosphorylation by casein kinase II.
association of arrestin-3 with the FSHR is dependent on receptor phosphorylation, however phosphorylation of the third intracellular loop residues is not needed for arrestin-3 association.
Title: The association of arrestin-3 with the follitropin receptor depends on receptor activation and phosphorylation.

Submit: New GeneRIF Correction See all (11)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P36575	P07550	ADRB2	HPRD	PubMed
P36575	O00203	AP3B1	HPRD	PubMed
P36575	P36575	ARR3	HPRD	PubMed
P36575	P04632	CAPNS1	HPRD	PubMed
P36575	Q00610	CLTC	HPRD	PubMed
P36575	P68400	CSNK2A1	HPRD	PubMed
P36575	O14641	DVL2	HPRD	PubMed
P36575	P23945	FSHR	HPRD	PubMed
P36575	Q14749	GNMT	HPRD	PubMed
P36575	O14733	MAP2K7	HPRD	PubMed
P36575	P04001	OPN1MW2	HPRD	PubMed
P36575	Q9UHM6	OPN4	HPRD	PubMed
P36575	P25105	PTAFR	HPRD	PubMed
P36575	Q8IZ40	RCOR2	HPRD	PubMed
P36575	P08100	RHO	HPRD	PubMed
P36575	Q93091	RNASE6	HPRD	PubMed
P36575	P12931	SRC	HPRD	PubMed
P36575	Q96IT1	ZNF496	HPRD	PubMed
BioGRID:106900	BioGRID:106671	AP1B1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106900	BioGRID:106672	AP2B1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106900	BioGRID:113788	AP3B2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106900	BioGRID:106901	ARRB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106900	BioGRID:107276	CAPNS1	BioGRID	PubMed	Two-hybrid
BioGRID:106900	BioGRID:107841	CSNK2A1	BioGRID	PubMed	Biochemical Activity
BioGRID:106900	BioGRID:107842	CSNK2A2	BioGRID	PubMed	Biochemical Activity
BioGRID:106900	BioGRID:108189	DVL2	BioGRID	PubMed	Two-hybrid
BioGRID:106900	BioGRID:118081	GNMT	BioGRID	PubMed	Two-hybrid
BioGRID:106900	BioGRID:114593	HGS	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106900	BioGRID:123747	ITCH	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106900	BioGRID:110358	MDM2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106900	BioGRID:111105	PARK2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106900	BioGRID:111696	PTAFR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106900	BioGRID:111942	RHO	BioGRID	PubMed	Reconstituted Complex
BioGRID:106900	BioGRID:111968	RNASE6	BioGRID	PubMed	Two-hybrid
BioGRID:106900	BioGRID:112592	SRC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106900	BioGRID:113722	STAM	BioGRID	PubMed	Co-localization
BioGRID:106900	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106900	BioGRID:124291	ZNF496	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid

Function	Evidence Code	Pubs
opsin binding	IEA Inferred from Electronic Annotation more info
phosphoprotein binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein domain specific binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
endocytosis	IEA Inferred from Electronic Annotation more info
regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
response to stimulus	IEA Inferred from Electronic Annotation more info
signal transduction	IEA Inferred from Electronic Annotation more info
visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	TAS Traceable Author Statement more info	PubMed
photoreceptor outer segment	IEA Inferred from Electronic Annotation more info
soluble fraction	TAS Traceable Author Statement more info	PubMed
synapse	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: arrestin-C

Names: arrestin-C; cArr; C-arrestin; X-arrestin; arrestin 4; cone arrestin; retinal cone arrestin-3

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004312.2 → NP_004303.2 arrestin-C

Status: VALIDATED

Source sequence(s)

AF033105, BC012096, BG472156

Consensus CDS

CCDS14399.1

UniProtKB/Swiss-Prot

P36575

Related

ENSP00000311538, OTTHUMP00000023467, ENST00000307959, OTTHUMT00000057055

Conserved Domains (1) summary

cl02844
Location:14 – 171
Blast Score: 274

Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000023.10 Reference GRCh37.p5 Primary Assembly

Range

69488185..69501690

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000155.1 Alternate HuRef

Range

63309253..63322604

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF076512.1	AAC27524.1
genomic	AL357752.19	CAI41490.1
		CAI41491.1
genomic	CH471132.2	EAX05348.1
		EAX05349.1
		EAX05350.1
		EAX05351.1
mRNA	AF033105.1	AAB84302.1
mRNA	BC012096.1	AAH12096.1
mRNA	BG472156.1	None
mRNA	CR456849.1	CAG33130.1
mRNA	EU883571.1	ACG60645.1
mRNA	U03626.1	AAC78395.1
other-genetic	DQ892243.2	ABM83169.1
other-genetic	DQ895444.2	ABM86370.1