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ARR3 arrestin 3 retinal (X-arrestin) [ Homo sapiens (human) ]

Gene ID: 407, updated on 18-May-2016
Official Symbol
ARR3provided by HGNC
Official Full Name
arrestin 3 retinal (X-arrestin)provided by HGNC
Primary source
HGNC:HGNC:710
See related
Ensembl:ENSG00000120500 HPRD:02358; MIM:301770; Vega:OTTHUMG00000021768
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARRX; cArr
Summary
The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016]
Orthologs
Location:
Xcen-q21
Exon count:
17
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (70263503..70281840)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (69488185..69501691)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373243 Neighboring gene RNA, 5S ribosomal pseudogene 507 Neighboring gene pyrimidinergic receptor P2Y4 Neighboring gene RAB41, member RAS oncogene family Neighboring gene PDZ domain containing 11 Neighboring gene kinesin family member 4A Neighboring gene trafficking protein particle complex 2-like pseudogene

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
opsin binding IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
endocytosis IEA
Inferred from Electronic Annotation
more info
 
regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
photoreceptor inner segment IDA
Inferred from Direct Assay
more info
PubMed 
photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
arrestin-C
Names
C-arrestin
X-arrestin
arrestin 3, retinal (X-arrestin)
arrestin 4
cone arrestin
retinal cone arrestin-3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004312.2NP_004303.2  arrestin-C

    See identical proteins and their annotated locations for NP_004303.2

    Status: REVIEWED

    Source sequence(s)
    AF033105, BC012096, BG472156
    Consensus CDS
    CCDS14399.1
    UniProtKB/Swiss-Prot
    P36575
    Related
    ENSP00000311538, OTTHUMP00000023467, ENST00000307959, OTTHUMT00000057055
    Conserved Domains (2) summary
    smart01017
    Location:193353
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:14171
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    70263503..70281840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530956.1XP_011529258.1  

    Conserved Domains (2) summary
    smart01017
    Location:231339
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:52209
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    69382163..69395648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)