MTA1-like [Drosophila melanogaster] - Gene

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Summary

Official Symbol: MTA1-likeprovided by Flybase
Primary source: FLYBASE:FBgn0027951
Locus tag: Dmel_CG2244
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2244; Dmel\CG2244; dMTA; dMTA-1; dMTA1-like; MTA-like; p120

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Genomic context

Location :: 83B7-83B7

Sequence :: Chromosome: 3R; NT_033777.2 (1464377..1474459, complement)

See MTA1-like in Epigenomics, MapViewer

Chromosome 3R - NT_033777.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:65899	BioGRID:624807	CG34340	BioGRID	PubMed	Two-hybrid
BioGRID:65899	BioGRID:66900	Caf1	BioGRID	PubMed	Two-hybrid
BioGRID:65899	BioGRID:69651	E5	BioGRID	PubMed	Two-hybrid
BioGRID:65899	BioGRID:66310	MBD-like	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:65899	BioGRID:64037	Rpd3	BioGRID	PubMed	Affinity Capture-MS

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General gene information

Homology

Homologs of the MTA1-like gene: The MTA1-like gene is conserved in human, , dog, mouse, rat, chicken, zebrafish, and mosquito.

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
histone deacetylase complex	IDA Inferred from Direct Assay more info	PubMed

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General protein information

Preferred Names: CG2244 gene product from transcript CG2244-RC

Names: CG2244-PA; CG2244-PB; CG2244-PC; MTA-like; MTA1-like; MTA1-like-PA; MTA1-like-PB; MTA1-like-PC; metastasis-associated-1-like-protein

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.2

Range

1464377..1474459, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001144539.2 → NP_001138011.1 MTA1-like, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

B7Z0T5

Related

FBpp0288645

Conserved Domains (5) summary

cd00202
Location:431 – 473
Blast Score: 125

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:19 – 226
Blast Score: 586

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

smart00717
Location:326 – 371
Blast Score: 109

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam01448
Location:205 – 257
Blast Score: 157

ELM2; ELM2 domain

cl15779
Location:326 – 369
Blast Score: 102

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_141309.3 → NP_649566.2 MTA1-like, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9VNF7

Related

FBpp0078383

Conserved Domains (5) summary

cd00202
Location:422 – 464
Blast Score: 124

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:3 – 217
Blast Score: 621

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

smart00717
Location:317 – 362
Blast Score: 108

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam01448
Location:196 – 248
Blast Score: 157

ELM2; ELM2 domain

cl15779
Location:317 – 360
Blast Score: 101

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_169086.2 → NP_730976.1 MTA1-like, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9VNF6

Related

FBpp0078382

Conserved Domains (6) summary

cd00202
Location:458 – 500
Blast Score: 125

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:155 – 253
Blast Score: 402

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

smart00717
Location:353 – 398
Blast Score: 108

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam01448
Location:232 – 284
Blast Score: 157

ELM2; ELM2 domain

cl02608
Location:3 – 74
Blast Score: 275

BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...

cl15779
Location:353 – 396
Blast Score: 101

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...