asl asterless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: aslprovided by FlyBase
Official Full Name: asterlessprovided by FlyBase
Primary source: FLYBASE:FBgn0261004
Locus tag: Dmel_CG2919
See related: AllianceGenome:FB:FBgn0261004
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Asl; ASL; Cep152; CG2919; DmAsl; Dmel\CG2919; mecD; MecD; sdu
Summary: Involved in several processes, including asymmetric cell division; negative regulation of centriole elongation; and organelle assembly. Located in centriole; ciliary basal body; and pericentriolar material. Human ortholog(s) of this gene implicated in Seckel syndrome 5 and primary autosomal recessive microcephaly 9. Orthologous to human CEP152 (centrosomal protein 152). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 83B4-83B5; 3-47.5 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (5603236..5606543, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (1428958..1432265, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

By halfway through pupal life, the centriole number decreases and structural defects, ranging from being incomplete or lacking B-tubules, are detected. Asl, Ana1 and Sas-4 are still present, suggesting that the centriole integrity does not depend on these proteins.
Title: The developing Drosophila eye - a new model to study centriole reduction.
ana1 mutants lack detectable centrosomes in vivo, that Ana1 is irreversibly incorporated into centrioles during their assembly and appears to play a more important role in maintaining Asl at centrioles than in initially recruiting Asl to centrioles...the N-terminal region of Ana1 (amino acids 1-935) is required to target Ana1 to centrioles through a direct interaction with Cep135, whereas the C-terminal region of Ana1.
Title: Drosophila Ana1 is required for centrosome assembly and centriole elongation.
Asl is not incorporated into daughter centrioles as they assemble during S phase but is only incorporated once mother and daughter separate at the end of mitosis.
Title: Asterless licenses daughter centrioles to duplicate for the first time in Drosophila embryos.
Asl not only targets Plk4 to centrioles but also modulates Plk4 stability and activity, explaining the ability of overexpressed Asl to drive centriole amplification.
Title: Two Polo-like kinase 4 binding domains in Asterless perform distinct roles in regulating kinase stability.
Data indicate that interphase centrioles are closely associated with Sas-4, Spd-2, Polo kinase, Pericentrin-like protein (Dplp), Asterless (Asl), Plk4 kinase, Centrosomin (Cnn) and gamma-tubulin.
Title: Structured illumination of the interface between centriole and peri-centriolar material.
Drosophila Asl and human CEP152 are required for the centrosomal loading of Plk4 in Drosophila and CPAP in human cells, respectively
Title: Asterless is a scaffold for the onset of centriole assembly.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in asymmetric cell division	IDA Inferred from Direct Assay more info	PubMed
involved_in centriole replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of centriole elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
located_in pericentriolar material	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: asterless

Names: CG2919-PA; asl-PA; mechanosensory D; mechanosensory mutant D; star dust

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

5603236..5606543 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_141300.2 → NP_649557.2 asterless [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649557.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7YTY4, Q9VNE4

Related

FBpp0078392

Conserved Domains (3) summary

TIGR02168
Location:97 → 709

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl14813
Location:484 → 629

GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

cl19219
Location:428 → 503

DUF342; Protein of unknown function (DUF342)