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    Snr1 Snf5-related 1 [ Drosophila melanogaster ]

    Gene ID: 40657, updated on 10-May-2012
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    Summary

    Official Symbol
    Snr1provided by Flybase
    Official Full Name
    Snf5-related 1provided by Flybase
    Primary source
    FLYBASE:FBgn0011715
    Locus tag
    Dmel_CG1064
    Gene type
    protein coding
    RNA name
    Snf5-related 1
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BAP45; CG1064; Dmel\CG1064; l(3)01319; snr; snr1; SNR1; Snr1/BAP45
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    Genomic context

    Location :
    83A4-83A4
    Sequence :
    Chromosome: 3R; NT_033777.2 (1296639..1298476)
    See Snr1 in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L35A Neighboring gene CG12162 gene product from transcript CG12162-RA Neighboring gene mitochondrial ribosomal protein L44 Neighboring gene Histone deacetylase 3 Neighboring gene Holocarboxylase synthetase Neighboring gene kinase suppressor of ras

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. The chromatin remodeling factor Bap55 functions through the TIP60 complex to regulate olfactory projection neuron dendrite targeting. Tea JS, et al. Neural Dev, 2011 Feb 1. PMID 21284845.
    3. Functional antagonism between histone H3K4 demethylases in vivo. Di Stefano L, et al. Genes Dev, 2011 Jan 1. PMID 21205864.
    4. Histone lysine demethylases function as co-repressors of SWI/SNF remodeling activities during Drosophila wing development. Curtis BJ, et al. Dev Biol, 2011 Feb 15. PMID 21146519.
    5. Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Reddy BA, et al. Mol Cell Biol, 2010 Nov. PMID 20733004.

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. our results support the view that SNR1, and specifically the repeat 2 region, has a critical role in mediating cell growth control functions of the metazoan SWI/SNF complexes.
      Title: The Drosophila SNR1 (SNF5/INI1) subunit directs essential developmental functions of the Brahma chromatin remodeling complex.
    2. Mutations in genes encoding other Brm complex components, including snr1 (BAP45), osa and deficiencies that remove BAP60 and BAP111 can also suppress the DmcycE(JP) eye phenotype.
      Title: Drosophila cyclin E interacts with components of the Brahma complex.
    3. This is the first instance of phosphorylation of SNR1 or any of its homologues and implicates the DYRK family of kinases with a role in chromatin remodelling.
      Title: dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX.
    4. SNR1 helps mediate associations between the Brm complex and DmcycE/CDK2 both in vitro and in vivo.
      Title: SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex.
    5. SNR1 is essential for some, but not all Brm functions, and it likely serves as an optional subunit, directing Brm complex activity to specific gene loci or cellular processes.
      Title: SNR1 is an essential subunit in a subset of Drosophila brm complexes, targeting specific functions during development.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:65866 BioGRID:68608 Ank    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:66033 Antp    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:65866 BioGRID:62650 Bap55    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65866 BioGRID:58653 Bap60    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:65866 BioGRID:61401 CG10465    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:58257 CG12065    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:59058 CG12432    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:65746 CG12581    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:61521 CG12835    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:59096 CG12985    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:62970 CG13423    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:65227 CG13728    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:59255 CG14207    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65866 BioGRID:58746 CG1461    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:59605 CG15356    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65866 BioGRID:60755 CG15482    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:58851 CG15646    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:58489 CG1737    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:65353 CG18135    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:59177 CG18259    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:58421 CG1826    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:65937 CG2017    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65866 BioGRID:64786 CG4069    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:57987 CG4119    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:67873 CG42331    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:62107 CG42700    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:63849 CG43444    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:62573 CG5065    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:60718 CG5525    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:64355 CG7185    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65866 BioGRID:66178 CG7352    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:66319 CG8301    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:65773 Cont    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:65193 Cpr73D    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:60939 CycE    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:65866 BioGRID:60646 CycY    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:66262 D1    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:64582 E(z)    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:65866 BioGRID:64332 ERR    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:63407 Gadd34    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:60006 H2.0    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:68056 HLHm3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65866 BioGRID:63105 HmgZ    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:68623 Lin29    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:63628 MED14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65866 BioGRID:67196 MED17    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65866 BioGRID:57686 MED18    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65866 BioGRID:66432 MED7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65866 BioGRID:62960 MED8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65866 BioGRID:68813 Mcr    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:63783 Mfap1    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:68499 Npc2g    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:67960 Nup358    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:61102 Pde11    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:68606 RpS3A    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:67562 SKIP    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:65996 Zif    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:58305 Zpr1    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:63665 bab1    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:65055 brm    BioGRID  PubMed Affinity Capture-MS; Phenotypic Enhancement 
    BioGRID:65866 BioGRID:61289 bru    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:63026 cpa    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:58301 dalao    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65866 BioGRID:58490 dsh    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65866 BioGRID:58076 dx    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:59261 e(y)3    BioGRID  PubMed Co-purification 
    BioGRID:65866 BioGRID:59468 ebi    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65866 BioGRID:59819 ed    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:65132 fax    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:67817 jar    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:66850 l(3)L1231    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:65145 mbf1    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:66996 mor    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:65866 BioGRID:67162 osa    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:65866 BioGRID:66104 pyd3    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:61073 rdo    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:63218 robo    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:58480 sisA    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:68777 sol    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:65151 tra    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:66813 trx    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:65866 BioGRID:58695 tth    BioGRID  PubMed Two-hybrid 
    BioGRID:65866 BioGRID:61926 whd    BioGRID  PubMed Two-hybrid 
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    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    SET domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to transcription coactivator activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    ATP-dependent chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    dendrite guidance IMP
    Inferred from Mutant Phenotype
    more info
    		  
    dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    embryonic development via the syncytial blastoderm NAS
    Non-traceable Author Statement
    more info
    		  
    epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    imaginal disc-derived wing margin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    imaginal disc-derived wing vein morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    imaginal disc-derived wing vein specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    instar larval or pupal development NAS
    Non-traceable Author Statement
    more info
    		  
    muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    brahma complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    brahma complex NAS
    Non-traceable Author Statement
    more info
    		  
    brahma complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nuclear chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CG1064 gene product from transcript CG1064-RA
    Names
    CG1064-PA
    Snf5-related 1
    Snr1-PA
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      1296639..1298476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169055.2 → NP_730935.1  Snf5-related 1 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24090
      Related
      FBpp0078331, FBtr0078682
      Conserved Domains (1) summary
      pfam04855
      Location:162 – 349
      Blast Score: 609
      SNF5; SNF5 / SMARCB1 / INI1
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014297.2 AAF52024.1
    mRNA U28485.1 AAC77830.1
    mRNA AY070501.1 AAL47972.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24090.1 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content