CD180 CD180 molecule [Homo sapiens] - Gene

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Summary

Official Symbol: CD180provided by HGNC
Official Full Name: CD180 moleculeprovided by HGNC
Primary source: HGNC:6726
See related: Ensembl:ENSG00000134061; HPRD:03749; MIM:602226; Vega:OTTHUMG00000131229
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LY64; Ly78; RP105; MGC126233; MGC126234
Summary: CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 5q12

Sequence :: Chromosome: 5; NC_000005.9 (66478103..66492617, complement)

See CD180 in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Both mouse and human RP105/MD-1 exhibit dimerization of the 1:1 RP105/MD-1 complex, demonstrating a novel organization.
Title: Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Lower mRNA expression of LY64 was detected in gingival tissue of chronic periodontitis patients compared to healthy controls.
Title: In vivo expression of Toll-like receptor 2, Toll-like receptor 4, CSF2 and LY64 in Chinese chronic periodontitis patients.
Data show that CD180, CD284 and CD14 expression is higher on normal B cells than on CD19+ B-cell chronic lymphocytic leukaemia cells.
Title: Different expression of CD180, CD284 and CD14 receptors on the CD19+ subpopulation of normal and B-CLL lymphocytes.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and risk of childhood leukemia.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
RP105 cross-linkaage enhanced B-lymphocyte proliferation, TLR9 expression, and growth.
Title: Potentiation of TLR9 responses for human naïve B-cell growth through RP105 signaling.
Observational study of gene-disease association. (HuGE Navigator)
Title: Risk of meningioma and common variation in genes related to innate immunity.
Expression of RP105 and TLR4 is altered on PBC monocytes, which appear to be hypersensitive to LPS, resulting in increased secretion of pro-inflammatory cytokines.
Title: Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis.
RP105 regulated TLR4 signaling in dendritic cells
Title: Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat downregulates the expression of many proteins, including RP105, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_005573.1	NP_004262.1	LY86	BIND	PubMed	MD-1 interacts with RP105
Q99467	O95711	LY86	HPRD	PubMed
BioGRID:110242	BioGRID:114839	LY86	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110242	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
inflammatory response	IEA Inferred from Electronic Annotation more info
innate immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
integral to membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: CD180 antigen

Names: CD180 antigen; lymphocyte antigen 64; radioprotective 105 kDa protein; lymphocyte antigen-64, radioprotective, 105kDa

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005582.2 → NP_005573.2 CD180 antigen precursor

Status: VALIDATED

Source sequence(s)

AL544501, AL570708, AW512119, BC109069, BP344300

Consensus CDS

CCDS3992.1

UniProtKB/Swiss-Prot

Q99467

Related

ENSP00000256447, OTTHUMP00000161890, ENST00000256447, OTTHUMT00000253973

Conserved Domains (4) summary

smart00082
Location:577 – 626
Blast Score: 90

LRRCT; Leucine rich repeat C-terminal domain

cl15309
Location:345 – 541
Blast Score: 103

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

pfam12799
Location:125 – 165
Blast Score: 78

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:421 – 481
Blast Score: 108

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p5 Primary Assembly

Range

66478103..66492617, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

63436781..63451299, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC026445.5 (66150..80646)	None
genomic	CH471137.2	EAW51318.1
mRNA	AK313177.1	BAG35994.1
mRNA	AL544501.3	None
mRNA	AL570708.3	None
mRNA	AW512119.1	None
mRNA	BC109069.1	AAI09070.1
mRNA	BC109070.1	AAI09071.1
mRNA	BP344300.1	None
mRNA	D83597.1	BAA12019.1