cno canoe [Drosophila melanogaster] - Gene

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Summary

Official Symbol: cnoprovided by Flybase
Official Full Name: canoeprovided by Flybase
Primary source: FLYBASE:FBgn0259212
Locus tag: Dmel_CG42312
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AF-6; anon-WO0172774.47; Canoe; CG2534; CG31537; CG42312; Cno; dlhA; Dmel\CG42312; lip; mis

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Genomic context

Location :: 82F4-82F6; 3-49 cM

Sequence :: Chromosome: 3R; NT_033777.2 (998392..1043147, complement)

See cno in Epigenomics, MapViewer

Chromosome 3R - NT_033777.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation
Title: Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation.
Canoe (Cno) and Pyd are required for proper Ena localization during dorsal closure, and strong genetic interactions suggest that Cno, Pyd, and Ena act together in regulating or anchoring the actin cytoskeleton during dorsal closure
Title: The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled.
Cno is required for maintaining attachment of the apical actomyosin network adherens junction in a planar-polarized way.
Title: A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension.
Cno function as a novel regulator of neuron-glia interactions, forming a complex with Shg, Wrapper and Neurexin IV.
Title: Canoe functions at the CNS midline glia in a complex with Shotgun and Wrapper-Nrx-IV during neuron-glia interactions.
repressive effect of Cno/AF-6 on these three signaling pathways through physical interactions with Ras, N and the cytoplasmic protein Dishevelled (Dsh), a key Wg effector
Title: The PDZ protein Canoe/AF-6 links Ras-MAPK, Notch and Wingless/Wnt signaling pathways by directly interacting with Ras, Notch and Dishevelled.
Cno regulates linkage between adherens junctions and the actin cytoskeleton during morphogenesis.
Title: The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction.
regulates key processes during asymmetric neuroblast division: the localization of cell-fate determinants, the orientation of the mitotic spindle, and the generation of unequal-sized daughter cells
Title: The PDZ protein Canoe regulates the asymmetric division of Drosophila neuroblasts and muscle progenitors.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:65834	BioGRID:67421	H	BioGRID	PubMed	Phenotypic Suppression
BioGRID:65834	BioGRID:57823	N	BioGRID	PubMed	Phenotypic Suppression
BioGRID:65834	BioGRID:64741	Nrx-IV	BioGRID	PubMed	Two-hybrid
BioGRID:65834	BioGRID:63773	R	BioGRID	PubMed	Two-hybrid
BioGRID:65834	BioGRID:63429	Rap2l	BioGRID	PubMed	Two-hybrid
BioGRID:65834	BioGRID:63974	Ras64B	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:65834	BioGRID:66301	Ras85D	BioGRID	PubMed	Phenotypic Enhancement; Two-hybrid
BioGRID:65834	BioGRID:72726	RecQ4	BioGRID	PubMed	Two-hybrid
BioGRID:65834	BioGRID:69288	bsk	BioGRID	PubMed	Phenotypic Suppression
BioGRID:65834	BioGRID:68605	ci	BioGRID	PubMed	Two-hybrid
	NP_523469.2	ed	BIND	PubMed	Ed interacts with an unspecified isoform of Cno.
BioGRID:65834	BioGRID:69588	kn	BioGRID	PubMed	Two-hybrid

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General gene information

Homology

Homologs of the cno gene: The cno gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, and mosquito.

Pathways from BioSystems

Adherens junctions interactions, organism-specific biosystem (from REACTOME)
Adherens junctions interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell junction organization, organism-specific biosystem (from REACTOME)
Cell junction organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell-Cell communication, organism-specific biosystem (from REACTOME)
Cell-Cell communication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell-cell junction organization, organism-specific biosystem (from REACTOME)
Cell-cell junction organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
actin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
JNK cascade	NAS Non-traceable Author Statement more info	PubMed
Notch signaling pathway	TAS Traceable Author Statement more info	PubMed
Ras protein signal transduction	TAS Traceable Author Statement more info	PubMed
compound eye development	IGI Inferred from Genetic Interaction more info	PubMed
dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
dorsal closure	TAS Traceable Author Statement more info	PubMed
dorsal closure, elongation of leading edge cells	NAS Non-traceable Author Statement more info	PubMed
embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
epidermis morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
establishment or maintenance of cell polarity	NAS Non-traceable Author Statement more info	PubMed
ommatidial rotation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of JNK cascade	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
adherens junction	IDA Inferred from Direct Assay more info	PubMed
adherens junction	NAS Non-traceable Author Statement more info	PubMed
adherens junction	TAS Traceable Author Statement more info	PubMed
cell cortex	IDA Inferred from Direct Assay more info	PubMed
connecting hemi-adherens junction	IDA Inferred from Direct Assay more info	PubMed
zonula adherens	TAS Traceable Author Statement more info	PubMed

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General protein information

Preferred Names: CG42312 gene product from transcript CG42312-RC

Names: CG42312-PC; CG42312-PD; CG42312-PE; afadin; canoe; cno-PC; cno-PD; cno-PE; dorsal holes A; lips; misty

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.2

Range

998392..1043147, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169025.2 → NP_730891.1 canoe, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q8IPP4

Related

FBpp0288987, FBtr0299709

Conserved Domains (5) summary

cd00060
Location:377 – 469
Blast Score: 119

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd00992
Location:841 – 925
Blast Score: 175

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01781
Location:257 – 343
Blast Score: 400

AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat

cd01782
Location:20 – 131
Blast Score: 602

AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat

pfam01843
Location:634 – 731
Blast Score: 304

DIL; DIL domain
NM_079508.3 → NP_524232.2 canoe, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9VN82

Related

FBpp0289752, FBtr0300525

Conserved Domains (5) summary

cd00060
Location:377 – 469
Blast Score: 119

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd00992
Location:1010 – 1094
Blast Score: 175

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01781
Location:257 – 343
Blast Score: 399

AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat

cd01782
Location:20 – 131
Blast Score: 601

AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat

pfam01843
Location:803 – 900
Blast Score: 304

DIL; DIL domain
NM_169026.2 → NP_730892.2 canoe, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q8IPP3

Related

FBpp0288988, FBtr0299710

Conserved Domains (5) summary

cd00060
Location:377 – 469
Blast Score: 118

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd00992
Location:1010 – 1094
Blast Score: 177

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01782
Location:20 – 131
Blast Score: 607

AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat

pfam01843
Location:803 – 900
Blast Score: 302

DIL; DIL domain

cl00155
Location:257 – 343
Blast Score: 397

UBQ; Ubiquitin-like proteins