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smash smallish [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40583, updated on 27-Mar-2024

Summary

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Official Symbol
smashprovided by FlyBase
Official Full Name
smallishprovided by FlyBase
Primary source
FLYBASE:FBgn0263346
Locus tag
Dmel_CG43427
See related
AllianceGenome:FB:FBgn0263346
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.95; CG1054; CG1055; CG14653; CG18253; CG31531; CG31534; CG43427; Dmel\CG43427; Smash
Old locus tag
Dmel_CG31531; Dmel_CG31534
Summary
Involved in morphogenesis of embryonic epithelium and protein localization to cell-cell junction. Located in zonula adherens. Is expressed in several structures, including adult head; embryonic/larval digestive system; epithelium; muscle system; and presumptive embryonic/larval system. Orthologous to human LIMCH1 (LIM and calponin homology domains 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
82D1-82D2; 3-47.1 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4659579..4712193)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (485301..537915)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Karyopherin beta 3 Neighboring gene long non-coding RNA:CR44156 Neighboring gene spartin Neighboring gene long non-coding RNA:CR44157 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44923 Neighboring gene eukaryotic translation initiation factor 3 subunit f1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of the smallish gene during Drosophila eye development. Tanaka R, et al. Gene, 2019 Feb 5. PMID 30359736
  2. The adherens junction-associated LIM domain protein Smallish regulates epithelial morphogenesis. Beati H, et al. J Cell Biol, 2018 Mar 5. PMID 29358210, Free PMC Article
  3. NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila. Lee C, et al. Mol Cell Biol, 2008 May. PMID 18332113, Free PMC Article
  4. Dendritic filopodia, Ripped Pocket, NOMPC, and NMDARs contribute to the sense of touch in Drosophila larvae. Tsubouchi A, et al. Curr Biol, 2012 Nov 20. PMID 23103192, Free PMC Article
  5. Deficiency screening for genomic regions with effects on environmental sensitivity of the sensory bristles of Drosophila melanogaster. Takahashi KH, et al. Evolution, 2012 Sep. PMID 22946809

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 4690692-4691118 mobile_element_type = transposon:INE-1{}4475

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in morphogenesis of embryonic epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to cell-cell junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in zonula adherens IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
smallish
Names
CG43427-PE
CG43427-PF
CG43427-PG
CG43427-PH
CG43427-PI
CG43427-PJ
CG43427-PM
CG43427-PN
CG43427-PO
CG43427-PP
smash
smash-PE
smash-PF
smash-PG
smash-PH
smash-PI
smash-PJ
smash-PM
smash-PN
smash-PO
smash-PP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    4659579..4712193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259984.2 → NP_001246913.1  smallish, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246913.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6R6
    Conserved Domains (1) summary
    pfam15949
    Location:14 → 152
    DUF4757; Domain of unknown function (DUF4757)

  2. NM_001259983.2 → NP_001246912.1  smallish, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246912.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K615
    Conserved Domains (2) summary
    pfam00412
    Location:1494 → 1530
    LIM; LIM domain
    pfam15949
    Location:14 → 152
    DUF4757; Domain of unknown function (DUF4757)

  3. NM_001259982.2 → NP_001246911.1  smallish, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246911.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K5Z4
    Conserved Domains (1) summary
    pfam15949
    Location:14 → 152
    DUF4757; Domain of unknown function (DUF4757)

  4. NM_001144532.3 → NP_001138004.2  smallish, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138004.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0T2
    Conserved Domains (1) summary
    pfam15949
    Location:14 → 152
    DUF4757; Domain of unknown function (DUF4757)

  5. NM_001144533.3 → NP_001138005.2  smallish, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138005.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0T1
    Conserved Domains (2) summary
    smart00132
    Location:1463 → 1521
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    pfam15949
    Location:14 → 152
    DUF4757; Domain of unknown function (DUF4757)

  6. NM_169015.3 → NP_730865.1  smallish, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730865.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5RIU0, Q0KIC3, Q8SX99
    UniProtKB/TrEMBL
    E2QCZ8
    Related
    FBpp0301005
    Conserved Domains (1) summary
    pfam15949
    Location:14 → 152
    DUF4757; Domain of unknown function (DUF4757)

  7. NM_176399.3 → NP_788576.1  smallish, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788576.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5RIU0, Q0KIC3, Q8SX99
    UniProtKB/TrEMBL
    E2QCZ8
    Related
    FBpp0301006
    Conserved Domains (1) summary
    pfam15949
    Location:14 → 152
    DUF4757; Domain of unknown function (DUF4757)

  8. NM_169014.3 → NP_730864.1  smallish, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730864.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5RIU0, Q0KIC3, Q8SX99
    UniProtKB/TrEMBL
    E2QCZ8
    Related
    FBpp0301004
    Conserved Domains (1) summary
    pfam15949
    Location:14 → 152
    DUF4757; Domain of unknown function (DUF4757)

  9. NM_176400.1 → NP_788577.1  smallish, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788577.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86BB6, Q8T0J7
    Conserved Domains (1) summary
    PRK13335
    Location:66 → 160
    PRK13335; superantigen-like protein; Reviewed

  10. NM_141231.4 → NP_649488.2  smallish, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649488.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0J7, Q9VN49
    Conserved Domains (1) summary
    smart00132
    Location:819 → 877
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K5Z4 A0A0B4K5Z4
A0A0B4K615 A0A0B4K615
A0A0B4K6R6 A0A0B4K6R6
B7Z0T1 B7Z0T1
B7Z0T2 B7Z0T2
E2QCZ8 E2QCZ8
Q0KIC3.1 Q0KIC3
Q86BB6 Q86BB6
Q8T0J7 Q8T0J7
Q9VN49 Q9VN49

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