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    LTK leukocyte receptor tyrosine kinase [ Homo sapiens ]

    Gene ID: 4058, updated on 11-May-2012
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    Summary

    Official Symbol
    LTKprovided by HGNC
    Official Full Name
    leukocyte receptor tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:6721
    See related
    Ensembl:ENSG00000062524; HPRD:01052; MIM:151520; Vega:OTTHUMG00000130339
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TYK1
    Summary
    The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
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    Genomic context

    Location :
    15q15.1-q21.1
    Sequence :
    Chromosome: 15; NC_000015.9 (41795840..41806085, complement)
    See LTK in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) Neighboring gene inositol-trisphosphate 3-kinase A Neighboring gene RNA polymerase II associated protein 1 Neighboring gene transcription elongation factor B (SIII), polypeptide 1 pseudogene 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen. Yamada S, et al. Biochem Biophys Res Commun, 2007 Nov 30. PMID 17910947.
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
    3. Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. Li N, et al. Hum Mol Genet, 2004 Jan 15. PMID 14695357.
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
    5. The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities. Espanel X, et al. Protein Sci, 2002 Oct. PMID 12237455.

    See all (18) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. polymorphic LTKs cause up-regulation of the PI3K pathway and possibly form one genetic component of susceptibility to abnormal proliferation of self-reactive B cells in systemic lupus erythematosus
      Title: Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P29376 P22681 CBL    HPRD  PubMed  
    P29376 O00750 PIK3C2B    HPRD  PubMed  
    P29376 P18031 PTPN1    HPRD  PubMed  
    P29376 P29353 SHC1    HPRD  PubMed  
    BioGRID:110236 BioGRID:107315 CBL    BioGRID  PubMed Biochemical Activity 
    BioGRID:110236 BioGRID:111313 PIK3R1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110236 BioGRID:111351 PLCG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110236 BioGRID:111736 PTPN1    BioGRID  PubMed Protein-peptide 
    BioGRID:110236 BioGRID:111831 RAF1    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular response to retinoic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    phosphatidylinositol 3-kinase cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    soluble fraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    leukocyte tyrosine kinase receptor
    Names
    leukocyte tyrosine kinase receptor
    protein tyrosine kinase 1
    NP_001129157.1
    NP_002335.2
    NP_996844.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135685.1 → NP_001129157.1  leukocyte tyrosine kinase receptor isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two internal coding exons and uses an alternate splice site in the central coding region, compared to variant 1. The resulting isoform (3) is missing two internal segments and has a short segment in an alternate reading frame but with the same N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AC016134, AK296892, CA394397
      Consensus CDS
      CCDS45237.1
      UniProtKB/TrEMBL
      B4DL89
      UniProtKB/TrEMBL
      E9PFX4
      Related
      ENSP00000392196, OTTHUMP00000248925, ENST00000453182, OTTHUMT00000419601
      Conserved Domains (1) summary
      cl09925
      Location:414 – 649
      Blast Score: 1263
      PKc_like; Protein Kinases, catalytic domain

    2. NM_002344.5 → NP_002335.2  leukocyte tyrosine kinase receptor isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK296892, CA394397, D16105
      Consensus CDS
      CCDS10077.1
      UniProtKB/TrEMBL
      B4DL89
      UniProtKB/Swiss-Prot
      P29376
      Related
      ENSP00000263800, OTTHUMP00000160858, ENST00000263800, OTTHUMT00000252690
      Conserved Domains (2) summary
      cd05036
      Location:503 – 779
      Blast Score: 1448
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
      pfam07714
      Location:510 – 777
      Blast Score: 971
      Pkinase_Tyr; Protein tyrosine kinase

    3. NM_206961.3 → NP_996844.1  leukocyte tyrosine kinase receptor isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is lacking one of the internal coding exons compared to variant 1. This results in an isoform (2) that is missing a 61 aa segment compared to isoform 1.
      Source sequence(s)
      AC016134, AK296892, CA394397, X60702
      Consensus CDS
      CCDS10078.1
      UniProtKB/TrEMBL
      B4DL89
      UniProtKB/Swiss-Prot
      P29376
      Related
      ENSP00000347293, OTTHUMP00000160859, ENST00000355166, OTTHUMT00000252691
      Conserved Domains (2) summary
      cd05036
      Location:442 – 718
      Blast Score: 1447
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
      pfam07714
      Location:449 – 716
      Blast Score: 968
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p5 Primary Assembly

      Range
      41795840..41806085, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      18644053..18654294, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC016134.7 (5310..9655) None
    genomic AC087721.4 (190711..196602) None
    genomic CH471125.1 EAW92494.1
      EAW92495.1
      EAW92496.1
      EAW92497.1
      EAW92498.1
      EAW92499.1
      EAW92500.1
      EAW92501.1
    genomic CS542498.1 CAM91186.1
    mRNA AK296892.1 BAG59451.1
    mRNA AK314006.1 None
    mRNA BC045607.1 AAH45607.1
    mRNA BC143903.1 None
    mRNA BX329448.2 None
    mRNA CA394397.1 None
    mRNA D16105.1 BAA03679.1
    mRNA DA452723.1 None
    mRNA DB331746.1 None
    mRNA X52213.1 CAA36460.1
    mRNA X60702.1 CAA43113.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29376.3 GenPept UniProtKB/Swiss-Prot:P29376
    Q4G0N3 GenPept UniProtKB/TrEMBL:Q4G0N3
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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