LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) [Homo sapiens] - Gene

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Summary

Official Symbol: LTBRprovided by HGNC
Official Full Name: lymphotoxin beta receptor (TNFR superfamily, member 3)provided by HGNC
Primary source: HGNC:6718
See related: Ensembl:ENSG00000111321; HPRD:02988; MIM:600979; Vega:OTTHUMG00000168356
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD18; TNFCR; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III
Summary: The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis. [provided by RefSeq, Jul 2008]
Annotation information: Annotation category: partial on reference assembly

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Genomic context

Location :: 12p13

Sequence :: Chromosome: 12; NC_000012.11 (6493357..6500734)

See LTBR in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Kidney-Tonifying plus Blood-Promoting Recipe regulates CD11b/CD18 and Bcl-2/Bax expression in blood leukocytes and improves microcirculatory status in aged patients with kidney deficiency and blood stasis syndrome.
Title: [Effect of Kidney-Tonifying and Blood-Promoting Recipe on the expression of CD11b/CD18 and Bcl-2/Bax in aged patients with kidney deficiency and blood stasis syndrome].
show that a cognate interaction between LTalphabeta on CD4(+) helper T cells and LTbeta receptor on DCs results in unique signals that are necessary for optimal CD8(+) T-cell expansion via a type I IFN-dependent mechanism
Title: LTβR signaling in dendritic cells induces a type I IFN response that is required for optimal clonal expansion of CD8+ T cells.
These results indicated that AdipoR1 interacted with LTBR and mediated the inhibition of LTBR-activated NF-kappaB pathway.
Title: Adiponectin inhibits lymphotoxin-β receptor-mediated NF-κB signaling in human umbilical vein endothelial cells.
LTbetaR levels are independently associated with atherosclerosis in multiple vascular beds
Title: Circulating lymphotoxin β receptor and atherosclerosis: observations from the Dallas Heart Study.
Increased potential for LTbeta receptor signaling, coupled with increased bioavailability due to lower decoy receptor-3 (DcR3) avidity, provides a mechanism for polymorphic variants in LIGHT to contribute to the pathogenesis of inflammatory diseases.
Title: Polymorphic variants of LIGHT (TNF superfamily-14) alter receptor avidity and bioavailability.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and risk of childhood leukemia.
the LTbetaR modifies the ubiquitin:NIK E3 ligase, and also acts as an allosteric regulator of the ubiquitin:TRAF E3 ligase
Title: Allosteric regulation of the ubiquitin:NIK and ubiquitin:TRAF3 E3 ligases by the lymphotoxin-beta receptor.
Modulation of cellular TRAF3 levels may thus contribute to regulation of NFkappaB-dependent gene expression by LTBR by affecting the balance of LTBR-dependent activation of canonical and non-canonical NFkappaB pathways.
Title: TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor.
Observational study of gene-disease association. (HuGE Navigator)
Title: Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.
Sustained LT signaling represents a pathway involved in hepatitis-induced hepatocellular carcinoma.
Title: A lymphotoxin-driven pathway to hepatocellular carcinoma.

Submit: New GeneRIF Correction See all (28)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_002333.1	NP_001157.1	BIRC2	BIND	PubMed	cIAP1 interacts with LTBR.
NP_002333.1	NP_063940.1	DIABLO	BIND	PubMed	Smac interacts with LTBR.
NP_002333.1	NP_751919.1	HCVgp1	BIND	PubMed	HCV core interacts with lymphotoxin-beta receptor.
NP_002333.1	NP_002333.1	LTBR	BIND	PubMed	LT-betaR interacts with LT-betaR.
NP_002333.1	NP_066961.2	TRAF2	BIND	PubMed	TRAF2 interacts with LTBR.
NP_002333.1	NP_663777.1	TRAF3	BIND	PubMed	TRAF3 interacts with LTBR.
NP_002333.1	BAA00452.1		BIND	PubMed	HCV core interacts with LT-betaR.
P36941	Q13489	BIRC3	HPRD	PubMed
P36941	Q9NR28	DIABLO	HPRD	PubMed
P36941	P01374	LTA	HPRD	PubMed
P36941	Q06643	LTB	HPRD	PubMed
P36941	P36941	LTBR	HPRD	PubMed
P36941	O43557	TNFSF14	HPRD	PubMed
P36941	Q12933	TRAF2	HPRD	PubMed
P36941	Q13114	TRAF3	HPRD	PubMed
P36941	Q9BUZ4	TRAF4	HPRD	PubMed
P36941	O00463	TRAF5	HPRD	PubMed
BioGRID:110233	BioGRID:121157	DIABLO	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110233	BioGRID:110233	LTBR	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:110233	BioGRID:114277	TNFSF14	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110233	BioGRID:113037	TRAF1	BioGRID	PubMed	Reconstituted Complex
BioGRID:110233	BioGRID:113038	TRAF2	BioGRID	PubMed	Reconstituted Complex
BioGRID:110233	BioGRID:113039	TRAF3	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex
BioGRID:110233	BioGRID:114979	TRAF4	BioGRID	PubMed	Reconstituted Complex
BioGRID:110233	BioGRID:113040	TRAF5	BioGRID	PubMed	Reconstituted Complex
BioGRID:110233	BioGRID:110678	TRIM37	BioGRID	PubMed	Reconstituted Complex
BioGRID:110233	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
identical protein binding	IPI Inferred from Physical Interaction more info
protein binding	IPI Inferred from Physical Interaction more info
receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
apoptotic process	IEA Inferred from Electronic Annotation more info
cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
interspecies interaction between organisms	IEA Inferred from Electronic Annotation more info
positive regulation of I-kappaB kinase/NF-kappaB cascade	IEP Inferred from Expression Pattern more info	PubMed
positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info
positive regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info
signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: tumor necrosis factor receptor superfamily member 3

Names: tumor necrosis factor receptor superfamily member 3; TNF-RIII; TNFR-III; lymphotoxin B receptor; lymphotoxin-beta receptor; TNFR superfamily, member 3; tumor necrosis factor C receptor; tumor necrosis factor receptor type III; tumor necrosis factor receptor 2-related protein; tumor necrosis factor receptor superfamily, member 3

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002342.1 → NP_002333.1 tumor necrosis factor receptor superfamily member 3 precursor

Status: REVIEWED

Source sequence(s)

L04270

Consensus CDS

CCDS8544.1

UniProtKB/Swiss-Prot

P36941

Related

ENSP00000228918, OTTHUMP00000238626, ENST00000228918, OTTHUMT00000399422

Conserved Domains (3) summary

cd00185
Location:51 – 146
Blast Score: 229

TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...

PRK03427
Location:264 – 342
Blast Score: 87

PRK03427; cell division protein ZipA; Provisional

cl12111
Location:132 – 210
Blast Score: 100

TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p5 Primary Assembly

Range

6493357..6500734

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

6347225..6354606

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB125676.1	BAD01488.1
genomic	AC005840.2 (93178..100553)	None
genomic	CH471116.2	EAW88801.1
		EAW88802.1
genomic	JA362588.1	CCA94576.1
mRNA	AK027080.1	None
mRNA	AK095418.1	BAG53051.1
mRNA	AK128019.1	None
mRNA	AK293187.1	BAH11468.1
mRNA	BC026262.1	AAH26262.1
mRNA	BX648074.1	None
mRNA	L04270.1	AAA36757.1
other-genetic	DQ891995.2	ABM82921.1
other-genetic	DQ895185.2	ABM86111.1