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Nepl11 Neprilysin-like 11 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40540, updated on 4-Apr-2024

Summary

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Official Symbol
Nepl11provided by FlyBase
Official Full Name
Neprilysin-like 11provided by FlyBase
Primary source
FLYBASE:FBgn0037230
Locus tag
Dmel_CG9780
See related
AllianceGenome:FB:FBgn0037230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9780; Dmel\CG9780
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be active in plasma membrane. Is expressed in adult head and embryonic/larval fat body. Orthologous to human KEL (Kell metallo-endopeptidase (Kell blood group)). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
82A1-82A1; 3-47.1 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4292274..4294840, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (117996..120562, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene flippy Neighboring gene long non-coding RNA:CR45597 Neighboring gene complexin Neighboring gene mir-929 stem loop Neighboring gene Vacuolar protein sorting 24 Neighboring gene Melanization Protease 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Binding of SU(VAR)3-9 Partially Depends on SETDB1 in the Chromosomes of Drosophila melanogaster. Maksimov DA, et al. Cells, 2019 Sep 5. PMID 31491894, Free PMC Article
  2. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
  3. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
  4. Juvenile hormone counteracts the bHLH-PAS transcription factors MET and GCE to prevent caspase-dependent programmed cell death in Drosophila. Liu Y, et al. Development, 2009 Jun. PMID 19465595
  5. Identification of circadian-clock-regulated enhancers and genes of Drosophila melanogaster by transposon mobilization and luciferase reporting of cyclical gene expression. Stempfl T, et al. Genetics, 2002 Feb. PMID 11861563, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Neprilysin-like 11
Names
CG9780-PA
Nepl11-PA
neprilysin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    4292274..4294840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141192.3 → NP_649449.1  Neprilysin-like 11 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649449.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VN01
    Related
    FBpp0078599
    Conserved Domains (1) summary
    cl14813
    Location:45 → 589
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VN01 Q9VN01

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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