mael maelstrom [Drosophila melanogaster] - Gene

Summary

Official Symbol: maelprovided by Flybase
Official Full Name: maelstromprovided by Flybase
Primary source: FLYBASE:FBgn0016034
Locus tag: Dmel_CG11254
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11254; Dmel\CG11254; mae1; MAEL

Chromosome 3L - NT_037436.3 Genomic Context describing neighboring genes

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Mael serves as a platform that nucleates other microtubule-organizing center components to form a functional MTOC in early oocyte development
Title: Maelstrom coordinates microtubule organization during Drosophila oogenesis through interaction with components of the MTOC.
Mael ensures proper differentiation in the germline stem cell lineage by repressing miR-7
Title: Drosophila maelstrom ensures proper germline stem cell lineage differentiation by repressing microRNA-7.
characterized a null allele of maelstrom (mael) and showed that
Title: Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage.

Submit: New GeneRIF Correction

Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:65723	BioGRID:66215	CG8159	BioGRID	PubMed	Two-hybrid
BioGRID:65723	BioGRID:58929	CG9911	BioGRID	PubMed	Two-hybrid
BioGRID:65723	BioGRID:61489	koi	BioGRID	PubMed	Two-hybrid
BioGRID:65723	BioGRID:78013	rl	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
intracellular mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
intracellular mRNA localization	TAS Traceable Author Statement more info	PubMed
negative regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
oocyte anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
oocyte microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
oocyte nucleus migration involved in oocyte dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
pole plasm mRNA localization	NAS Non-traceable Author Statement more info	PubMed
protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of pole plasm oskar mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
P granule	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

Names: CG11254-PA; CG11254-PB; CG11254-PC; mael-PA; mael-PB; mael-PC; maelstrom

The following sections contain reference sequences that belong to a specific genome build. Explain