LRPAP1 low density lipoprotein receptor-related protein associated protein 1 [Homo sapiens] - Gene

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Summary

Official Symbol: LRPAP1provided by HGNC
Official Full Name: low density lipoprotein receptor-related protein associated protein 1provided by HGNC
Primary source: HGNC:6701
Locus tag: RP11-529E10.3
See related: Ensembl:ENSG00000163956; HPRD:00082; MIM:104225; Vega:OTTHUMG00000090299
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RAP; MRAP; A2RAP; HBP44; A2MRAP; MGC138272

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Genomic context

Location :: 4p16.3

Sequence :: Chromosome: 4; NC_000004.11 (3505324..3534224, complement)

See LRPAP1 in Epigenomics, MapViewer

Chromosome 4 - NC_000004.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LRP1-C/T, A2M-Ile/Val and APOE-epsilon 2/epsilon 3/epsilon 4 polymorphisms are associated with AD.
Title: Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Findings reveal that RAP is a novel Abeta-binding protein that promotes cellular internalization of Abeta.
Title: Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake.
Our study suggests that LRPAP1-D and APOE E4 alleles significantly increase the susceptibility to degenerative dementias.
Title: LRP-associated protein gene (LRPAP1) and susceptibility to degenerative dementia.
Low-density lipoprotein receptor-related protein associated protein (LRPAP1) insertion/deletion polymorphism is associated with gallstone disease and gallbladder carcinoma
Title: Lipoprotein receptor associated protein (LRPAP1) insertion/deletion polymorphism: association with gallbladder cancer susceptibility.
Low-density lipoprotein receptor-related protein-associated protein (LRPAP1) gene IVS5 insertion/deletion polymorphism is not a risk factor for gallstone disease in a Polish population.
Title: Low-density lipoprotein receptor-related protein-associated protein (LRPAP1) gene IVS5 insertion/deletion polymorphism is not a risk factor for gallstone disease in a Polish population.
Observational study of genotype prevalence. (HuGE Navigator)
Title: ACE and LRPAP1 insertion-deletion polymorphisms in a northern Ivory Coast population.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Alpha2-macroglobulin, lipoprotein receptor-related protein and lipoprotein receptor-associated protein and the genetic risk for developing Alzheimer's disease.
Observational study of gene-disease association. (HuGE Navigator)
Title: Cholesterol metabolism gene polymorphisms and the risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China.
LRP-1/LDLR-mediated uptake of A beta results in degeneration of perivascular cells.
Title: Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells.

Submit: New GeneRIF Correction See all (20)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P30533	P01130	LDLR	HPRD	PubMed
P30533	Q07954	LRP1	HPRD	PubMed
P30533	Q9NZR2	LRP1B	HPRD	PubMed
P30533	P98164	LRP2	HPRD	PubMed
P30533	Q14114	LRP8	HPRD	PubMed
P30533	P28482	MAPK1	HPRD	PubMed
P30533	P27361	MAPK3	HPRD	PubMed
P30533	Q14181	POLA2	HPRD	PubMed
P30533	O15355	PPM1G	HPRD	PubMed
P30533	Q9NQC3	RTN4	HPRD	PubMed
P30533	Q92673	SORL1	HPRD	PubMed
P30533	Q99523	SORT1	HPRD	PubMed
P30533	P98155	VLDLR	HPRD	PubMed
BioGRID:110221	BioGRID:108293	EIF4EBP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110221	BioGRID:110141	LDLR	BioGRID	PubMed	Reconstituted Complex
BioGRID:110221	BioGRID:110215	LRP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:110221	BioGRID:110216	LRP2	BioGRID	PubMed	Reconstituted Complex
BioGRID:110221	BioGRID:113579	LRP8	BioGRID	PubMed	Reconstituted Complex
BioGRID:110221	BioGRID:108757	MTOR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110221	BioGRID:117176	POLA2	BioGRID	PubMed	Two-hybrid
BioGRID:110221	BioGRID:111831	RAF1	BioGRID	PubMed	Two-hybrid
BioGRID:110221	BioGRID:111834	RALA	BioGRID	PubMed	Reconstituted Complex
BioGRID:110221	BioGRID:111836	RALGDS	BioGRID	PubMed	Two-hybrid
BioGRID:110221	BioGRID:111839	RANBP2	BioGRID	PubMed	Two-hybrid
BioGRID:110221	BioGRID:121400	RTN4	BioGRID	PubMed	Two-hybrid
BioGRID:110221	BioGRID:112536	SORL1	BioGRID	PubMed	Co-purification; Reconstituted Complex
BioGRID:110221	BioGRID:112180	SORT1	BioGRID	PubMed	Reconstituted Complex
BioGRID:110221	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110221	BioGRID:113277	VLDLR	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
asialoglycoprotein receptor activity	TAS Traceable Author Statement more info	PubMed
heparin binding	IEA Inferred from Electronic Annotation more info
lipase binding	IEA Inferred from Electronic Annotation more info
low-density lipoprotein particle receptor binding	IDA Inferred from Direct Assay more info	PubMed
receptor antagonist activity	IDA Inferred from Direct Assay more info	PubMed
unfolded protein binding	TAS Traceable Author Statement more info	PubMed
very-low-density lipoprotein particle receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
negative regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
negative regulation of signal transduction	IDA Inferred from Direct Assay more info	PubMed
negative regulation of very-low-density lipoprotein particle clearance	IDA Inferred from Direct Assay more info	PubMed
protein folding	TAS Traceable Author Statement more info	PubMed
vesicle-mediated transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cell surface	IEA Inferred from Electronic Annotation more info
cytoplasm	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	TAS Traceable Author Statement more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
rough endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
vesicle	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: alpha-2-macroglobulin receptor-associated protein

Names: alpha-2-macroglobulin receptor-associated protein; alpha-2-MRAP; lipoprotein receptor associated protein; alpha-2-macroglobulin receptor-associated protein 1; low density lipoprotein receptor-related protein-associated protein 1; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002337.3 → NP_002328.1 alpha-2-macroglobulin receptor-associated protein precursor

Status: VALIDATED

Source sequence(s)

AK222504, AL590235, BC112067, BX647984, DB035408

Consensus CDS

CCDS3371.1

UniProtKB/Swiss-Prot

P30533

Related

ENSP00000421922, OTTHUMP00000115346, ENST00000500728, OTTHUMT00000206659

Conserved Domains (2) summary

pfam06400
Location:26 – 134
Blast Score: 452

Alpha-2-MRAP_N; Alpha-2-macroglobulin RAP, N-terminal domain

pfam06401
Location:144 – 357
Blast Score: 694

Alpha-2-MRAP_C; Alpha-2-macroglobulin RAP, C-terminal domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000004.11 Reference GRCh37.p5 Primary Assembly

Range

3505324..3534224, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000136.1 Alternate HuRef

Range

3444900..3473683, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF035767.1	AAC67373.1
genomic	AL590235.23	CAM21451.1
genomic	CH471131.2	EAW82460.1
		EAW82461.1
genomic	CS101462.1	CAJ00723.1
genomic	U06976.1	AAA87889.1
mRNA	AK222504.1	BAD96224.1
mRNA	AK222527.1	BAD96247.1
mRNA	AK292321.1	BAF85010.1
mRNA	AK310598.1	None
mRNA	AK310851.1	None
mRNA	AK311600.1	None
mRNA	AK312698.1	BAG35576.1
mRNA	AL365520.1	None
mRNA	AL365522.1	None
mRNA	BC007841.1	AAH07841.1
mRNA	BC105074.1	AAI05075.1
mRNA	BC112067.1	AAI12068.1
mRNA	BX647984.1	None
mRNA	DB035408.1	None
mRNA	M63959.1	AAA51553.1