CycH Cyclin H [Drosophila melanogaster] - Gene

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Summary

Official Symbol: CycHprovided by Flybase
Official Full Name: Cyclin Hprovided by Flybase
Primary source: FLYBASE:FBgn0022936
Locus tag: Dmel_CG7405
Gene type: protein coding
RNA name: cyclin H
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 142767_at; CG7405; Dmel\CG7405

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Genomic context

Location :: 78F3-78F3

Sequence :: Chromosome: 3L; NT_037436.3 (21815101..21816509)

See CycH in Epigenomics, MapViewer

Chromosome 3L - NT_037436.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:65669	BioGRID:63648	CG13900	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:64811	CG14119	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:59148	CG15043	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:63098	CG15676	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:72486	CG17508	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:57563	CG18273	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:68004	CG4673	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:68226	CG5003	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:60478	CG5375	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:64118	CG5568	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:60452	CG5708	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:60446	CG5731	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:60545	CG7296	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:58854	CG8128	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:62567	Cdk4	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:57951	Cdk7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:65669	BioGRID:66871	CycC	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:61444	EcR	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:61939	Mat1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:65669	BioGRID:67630	Nup133	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:57689	Pgam5	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:62820	SP2637	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:60495	cdc2	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:67428	cdc2c	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:60833	cenG1A	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:64513	fry	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:61396	gus	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:71508	heph	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:68607	pan	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:65883	rev7	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:65300	skl	BioGRID	PubMed	Two-hybrid
BioGRID:65669	BioGRID:68433	spn-A	BioGRID	PubMed	Two-hybrid

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General gene information

Homology

Homologs of the CycH gene: The CycH gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, A.thaliana, and rice.

Pathways from BioSystems

Basal transcription factors, organism-specific biosystem (from KEGG)
Basal transcription factors, organism-specific biosystem
Basal transcription factors
Basal transcription factors, conserved biosystem (from KEGG)
Basal transcription factors, conserved biosystem
Basal transcription factors
Cell cycle, organism-specific biosystem (from WikiPathways)
Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
DNA Repair, organism-specific biosystem (from REACTOME)
DNA Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dual incision reaction in GG-NER, organism-specific biosystem (from REACTOME)
Dual incision reaction in GG-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dual incision reaction in TC-NER, organism-specific biosystem (from REACTOME)
Dual incision reaction in TC-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Eukaryotic Transcription Initiation, organism-specific biosystem (from WikiPathways)
Eukaryotic Transcription Initiation, organism-specific biosystemIn eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the pre...
Formation of RNA Pol II elongation complex, organism-specific biosystem (from REACTOME)
Formation of RNA Pol II elongation complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Formation of incision complex in GG-NER, organism-specific biosystem (from REACTOME)
Formation of incision complex in GG-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Formation of the Early Elongation Complex, organism-specific biosystem (from REACTOME)
Formation of the Early Elongation Complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Global Genomic NER (GG-NER), organism-specific biosystem (from REACTOME)
Global Genomic NER (GG-NER), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Holo-TFIIH complex, organism-specific biosystem (from KEGG)
Holo-TFIIH complex, organism-specific biosystemStructural complex; Genetic information processing; Repair system
Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
Nucleotide Excision Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nucleotide excision repair, organism-specific biosystem (from KEGG)
Nucleotide excision repair, organism-specific biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
Nucleotide excision repair, conserved biosystem (from KEGG)
Nucleotide excision repair, conserved biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
RNA Pol II CTD phosphorylation and interaction with CE, organism-specific biosystem (from REACTOME)
RNA Pol II CTD phosphorylation and interaction with CE, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Pre-transcription Events, organism-specific biosystem (from REACTOME)
RNA Polymerase II Pre-transcription Events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Promoter Escape, organism-specific biosystem (from REACTOME)
RNA Polymerase II Promoter Escape, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Elongation, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Elongation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Initiation, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Initiation And Promoter Clearance, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Initiation And Promoter Clearance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transcription-coupled NER (TC-NER), organism-specific biosystem (from REACTOME)
Transcription-coupled NER (TC-NER), organism-specific biosystemcomputationally inferred pathway (not manually curated)
mRNA Capping, organism-specific biosystem (from REACTOME)
mRNA Capping, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
contributes_to RNA polymerase II carboxy-terminal domain kinase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to cyclin-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
cyclin-dependent protein kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info
protein kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
regulation of cyclin-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
transcription initiation from RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
carboxy-terminal domain protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
holo TFIIH complex	IDA Inferred from Direct Assay more info	PubMed
holo TFIIH complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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General protein information

Preferred Names: CG7405 gene product from transcript CG7405-RA

Names: CG7405-PA; CycH-PA; CyclinH; cyclin H; cyclin-H

NP_524207.1

EC 2.7.1.-

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.3

Range

21815101..21816509

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079483.2 → NP_524207.1 cyclin H [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

O76513

UniProtKB/TrEMBL

Q32KG2

Related

FBpp0078093, FBtr0078439

Conserved Domains (2) summary

cd00043
Location:63 – 127
Blast Score: 129

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

TIGR00569
Location:2 – 307
Blast Score: 1188

ccl1; cyclin ccl1