GALC galactosylceramidase [Canis lupus familiaris (dog)] - Gene

Summary

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Gene symbol: GALC
Gene description: galactosylceramidase
See related: Ensembl:ENSCAFG00000017337
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis

Genomic context

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Location :: chromosome: 8

Sequence :: Chromosome: 8; NC_006590.3 (59267816..59324825, complement)

See GALC in MapViewer

Chromosome 8 - NC_006590.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from BioSystems

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Glycosphingolipid metabolism, organism-specific biosystem (from REACTOME)
Glycosphingolipid metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Lysosome, organism-specific biosystem (from KEGG)
Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
Lysosome, conserved biosystem (from KEGG)
Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Sphingolipid metabolism, organism-specific biosystem (from KEGG)
Sphingolipid metabolism, organism-specific biosystem
Sphingolipid metabolism
Sphingolipid metabolism, organism-specific biosystem (from REACTOME)
Sphingolipid metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Sphingolipid metabolism, conserved biosystem (from KEGG)
Sphingolipid metabolism, conserved biosystem
Sphingolipid metabolism

General gene information

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Homology

Homologs of the GALC gene: The GALC gene is conserved in human, chimpanzee, Rhesus monkey, cow, mouse, rat, chicken, and zebrafish.
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

General protein information

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Preferred Names: galactocerebrosidase

Names: galactocerebrosidase; GALCERase; galactocerebroside beta-galactosidase; galactosylceramidase (Krabbe disease); galactosylceramide beta-galactosidase

NP_001003238.1

EC 3.2.1.46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003238.1 → NP_001003238.1 galactocerebrosidase precursor

Status: PROVISIONAL

Source sequence(s)

L76184

UniProtKB/Swiss-Prot

P54804

Related

ENSCAFP00000025549, ENSCAFT00000027473

Conserved Domains (1) summary

pfam02057
Location:27 – 669
Blast Score: 3304

Glyco_hydro_59; Glycosyl hydrolase family 59