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    LRP3 low density lipoprotein receptor-related protein 3 [ Homo sapiens ]

    Gene ID: 4037, updated on 11-May-2012

    Summary

    Official Symbol
    LRP3provided by HGNC
    Official Full Name
    low density lipoprotein receptor-related protein 3provided by HGNC
    Primary source
    HGNC:6695
    See related
    Ensembl:ENSG00000130881; HPRD:04406; MIM:603159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

    Genomic context

    Location :
    19q13.11
    Sequence :
    Chromosome: 19; NC_000019.9 (33685599..33699773)
    See LRP3 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene G patch domain containing 1 Neighboring gene WD repeat domain 88 Neighboring gene solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 Neighboring gene uncharacterized LOC80054 Neighboring gene CCAAT/enhancer binding protein (C/EBP), alpha

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O75074 Q9UJY5 GGA1    HPRD  PubMed  
    O75074 Q9UJY4 GGA2    HPRD  PubMed  

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    receptor-mediated endocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    low-density lipoprotein receptor-related protein 3
    Names
    low-density lipoprotein receptor-related protein 3
    LRP-3
    hLRp105
    105 kDa low-density lipoprotein receptor-related protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002333.3NP_002324.2  low-density lipoprotein receptor-related protein 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AB009462, AC008738, AK126750, BC007408, BU739456, DA496540
      Consensus CDS
      CCDS12430.1
      UniProtKB/Swiss-Prot
      O75074
      Related
      ENSP00000253193, ENST00000253193
      Conserved Domains (2) summary
      cd00041
      Location:43156
      Blast Score: 262
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:166200
      Blast Score: 129
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      33685599..33699773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      30187589..30201641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC008738.7 (63701..77982) None
    mRNA AB009462.1 BAA32330.1
    mRNA AF085860.1 None
    mRNA AK074751.1 BAG51998.1
    mRNA AK126750.1 None
    mRNA AK129963.1 BAC85262.1
    mRNA AK295505.1 BAG58424.1
    mRNA AK296536.1 BAG59164.1
    mRNA AK316314.1 BAH14685.1
    mRNA BC007408.2 AAH07408.1
    mRNA BU739456.1 None
    mRNA DA496540.1 None
    mRNA DR002806.1 None
    other-genetic EU176387.1 ABW03838.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75074.2 GenPept UniProtKB/Swiss-Prot:O75074

      Supplemental Content

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