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    LRP1 low density lipoprotein receptor-related protein 1 [ Homo sapiens (human) ]

    Gene ID: 4035, updated on 14-May-2013
    Official Symbol
    LRP1provided by HGNC
    Official Full Name
    low density lipoprotein receptor-related protein 1provided by HGNC
    Primary source
    HGNC:6692
    See related
    Ensembl:ENSG00000123384; HPRD:00138; MIM:107770; Vega:OTTHUMG00000044412
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APR; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R
    Summary
    The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. [provided by RefSeq, Jan 2010]
    Location :
    12q13.3
    Sequence :
    Chromosome: 12; NC_000012.11 (57522282..57607142)
    See LRP1 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 194A Neighboring gene NGFI-A binding protein 2 (EGR1 binding protein 2) Neighboring gene signal transducer and activator of transcription 6, interleukin-4 induced Neighboring gene microRNA 1228 Neighboring gene neurexophilin 4 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 Neighboring gene serine hydroxymethyltransferase 2 (mitochondrial)

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Protein Gene Interaction Pubs
    Tat, p14 tat HIV-1 Tat and TGF-beta secretion enhance parasite entry in human macrophages by upregulating surface expression of CD91/LRP-1 PubMed
    tat HIV-1 Tat treatment induces the formation of complexes involving the low-density lipoprotein receptor-related protein (LRP), postsynaptic density protein-95 (PSD-95), and N-methyl-d-aspartic acid (NMDA) receptors at the neuron surface PubMed
    tat HIV-1 Tat decreases the scaffolding protein postsynaptic density 95 (PSD95) in synapses via the low-density lipoprotein receptor-related protein (LRP); Tat decreases PSD95 in a concentration-dependent manner PubMed
    tat Binding of HIV-1 Tat to LRP inhibits neuronal binding, uptake and degradation of physiological ligands for LRP, including alpha2-macroglobulin, apolipoprotein E4, amyloid precursor and amyloid beta-protein PubMed
    tat LRP binds to the core domain of HIV-1 Tat (amino acids 37-48) and promotes the efficient uptake of Tat into neurons, suggesting Tat may mediate HIV-1 induced neuropathology through disruption of LRP ligands and activation of neuronal genes PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002323.1 NP_001902.1 CTSG    BIND  PubMed LRP interacts with Cathepsin G. 
    NP_002323.1 NP_001963.1 ELANE    BIND  PubMed LRP interacts with Elastase 2. 
    NP_002323.1 NP_000286.3 SERPINA1    BIND  PubMed LRP interacts with alpha-1-PI. 
    NP_002323.1 NP_001076.1 SERPINA3    BIND  PubMed LRP interacts with alpha-1-ACT. 
    NP_002323.1     BIND  PubMed Alpha-1 ACT/cathepsin G complex interacts with LRP. 
    NP_002323.1     BIND  PubMed Alpha-1 PI/cathepsin G complex interacts with LRP. 
    NP_002323.1     BIND  PubMed Alpha-1 PI/neutrophil elastase complex interacts with LRP. 
    Q07954 P01023 A2M    HPRD  PubMed  
    Q07954 Q9UM13 ANAPC10    HPRD  PubMed  
    Q07954 Q99767 APBA2    HPRD  PubMed  
    Q07954 O00213 APBB1    HPRD  PubMed  
    Q07954 P02649 APOE    HPRD  PubMed  
    Q07954 P05067 APP    HPRD  PubMed  
    Q07954 P56817 BACE1    HPRD  PubMed  
    Q07954 P01024 C3    HPRD  PubMed  
    Q07954 P04003 C4BPA    HPRD  PubMed  
    Q07954 P27797 CALR    HPRD  PubMed  
    Q07954 P27824 CANX    HPRD  PubMed  
    Q07954 Q03135 CAV1    HPRD  PubMed  
    Q07954 P27701 CD82    HPRD  PubMed  
    Q07954 P29279 CTGF    HPRD  PubMed  
    Q07954 P08311 CTSG    HPRD  PubMed  
    Q07954 O75553 DAB1    HPRD  PubMed  
    Q07954 P78352 DLG4    HPRD  PubMed  
    Q07954 P08246 ELANE    HPRD  PubMed  
    Q07954 P00451 F8    HPRD  PubMed  
    Q07954 P00740 F9    HPRD  PubMed  
    Q07954 P09958 FURIN    HPRD  PubMed  
    Q07954 O14908 GIPC1    HPRD  PubMed  
    Q07954 O00178 GTPBP1    HPRD  PubMed  
    Q07954 CED6 GULP1    HPRD  PubMed  
    Q07954 P14625 HSP90B1    HPRD  PubMed  
    Q07954 O14713 ITGB1BP1    HPRD  PubMed  
    Q07954 Q92993 KAT5    HPRD  PubMed  
    Q07954 P11150 LIPC    HPRD  PubMed  
    Q07954 P06858 LPL    HPRD  PubMed  
    Q07954 Q07954 LRP1    HPRD  PubMed  
    Q07954 P30533 LRPAP1    HPRD  PubMed  
    Q07954 P02788 LTF    HPRD  PubMed  
    Q07954 Q9UQF2 MAPK8IP1    HPRD  PubMed  
    Q07954 Q13387 MAPK8IP2    HPRD  PubMed  
    Q07954 P21741 MDK    HPRD  PubMed  
    Q07954 P45452 MMP13    HPRD  PubMed  
    Q07954 P50281 MMP14    HPRD  PubMed  
    Q07954 P51511 MMP15    HPRD  PubMed  
    Q07954 P51512 MMP16    HPRD  PubMed  
    Q07954 Q9ULZ9 MMP17    HPRD  PubMed  
    Q07954 O75052 NOS1AP    HPRD  PubMed  
    Q07954 P01127 PDGFB    HPRD  PubMed  
    Q07954 P00750 PLAT    HPRD  PubMed  
    Q07954 Q03405 PLAUR    HPRD  PubMed  
    Q07954 P17612 PRKACA    HPRD  PubMed  
    Q07954 Q9NY46 SCN3A    HPRD  PubMed  
    Q07954 P01009 SERPINA1    HPRD  PubMed  
    Q07954 P05121 SERPINE1    HPRD  PubMed  
    Q07954 P29353 SHC1    HPRD  PubMed  
    Q07954 P12757 SKIL    HPRD  PubMed  
    Q07954 Q15036 SNX17    HPRD  PubMed  
    Q07954 P12931 SRC    HPRD  PubMed  
    Q07954 P57105 SYNJ2BP    HPRD  PubMed  
    Q07954 P07996 THBS1    HPRD  PubMed  
    Q07954 P56704 WNT3A    HPRD  PubMed  
    BioGRID:110215 BioGRID:106524 A2M    BioGRID  PubMed Co-crystal Structure 
    BioGRID:110215 BioGRID:115665 ANAPC10    BioGRID  PubMed Two-hybrid 
    BioGRID:110215 BioGRID:121229 ANKS1B    BioGRID  PubMed Two-hybrid 
    BioGRID:110215 BioGRID:106818 APBA2    BioGRID  PubMed Two-hybrid 
    BioGRID:110215 BioGRID:106819 APBB1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110215 BioGRID:106845 APOE    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110215 BioGRID:107227 CACNA1A    BioGRID  PubMed Two-hybrid 
    BioGRID:110215 BioGRID:107250 CALCR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110215 BioGRID:107262 CALR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110215 BioGRID:107271 CANX    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110215 BioGRID:120212 CC2D1A    BioGRID  PubMed Two-hybrid 
    BioGRID:110215 BioGRID:120861 CHFR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110215 BioGRID:113724 CUBN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110215 BioGRID:107970 DAB1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110215 BioGRID:107971 DAB2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110215 BioGRID:108086 DLG4    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110215 BioGRID:108455 F8    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110215 BioGRID:108456 F9    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110215 BioGRID:117654 FBXO6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110215 BioGRID:115978 GIPC1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110215 BioGRID:119550 GULP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110215 BioGRID:115308 HNRPDL    BioGRID  PubMed Two-hybrid 
    BioGRID:110215 BioGRID:114689 ITGB1BP1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110215 BioGRID:115779 KAT5    BioGRID  PubMed FRET 
    BioGRID:110215 BioGRID:110178 LIPC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110215 BioGRID:110205 LPL    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110215 BioGRID:110221 LRPAP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110215 BioGRID:114864 MAPK8IP1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110215 BioGRID:117086 MAPK8IP2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110215 BioGRID:116581 MAPRE1    BioGRID  PubMed Two-hybrid 
    BioGRID:110215 BioGRID:110357 MDK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110215 BioGRID:110466 MMP14    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110215 BioGRID:115071 NOS1AP    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110215 BioGRID:111181 PDGFB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110215 BioGRID:122240 PDIA2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110215 BioGRID:120352 PID1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110215 BioGRID:111343 PLAT    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110215 BioGRID:111345 PLAUR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110215 BioGRID:120486 RIC8B    BioGRID  PubMed Two-hybrid 
    BioGRID:110215 BioGRID:112233 SCN3A    BioGRID  PubMed Two-hybrid 
    BioGRID:110215 BioGRID:111091 SERPINE1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110215 BioGRID:112361 SHC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110215 BioGRID:112389 SKIL    BioGRID  PubMed Two-hybrid 
    BioGRID:110215 BioGRID:112509 SNRNP70    BioGRID  PubMed Two-hybrid 
    BioGRID:110215 BioGRID:115128 SNX17    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110215 BioGRID:112592 SRC    BioGRID  PubMed Biochemical Activity 
    BioGRID:110215 BioGRID:120614 SYNJ2BP    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110215 BioGRID:112915 THBS1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110215 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110215 BioGRID:115285 USP3    BioGRID  PubMed Affinity Capture-MS 
    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimers Disease, organism-specific biosystem (from WikiPathways)
      Alzheimers Disease, organism-specific biosystemThis pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondria...
    • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
      Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemScavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). So...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases associated with visual transduction, organism-specific biosystem (from REACTOME)
      Diseases associated with visual transduction, organism-specific biosystemThe process of vision involves two stages; the retinoid cycle which supplies and regenerates the visual chromophore required for vision and phototransduction which propagates the light signal. Defect...
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • PDGFR-beta signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      PDGFR-beta signaling pathway, organism-specific biosystem
      PDGFR-beta signaling pathway
    • Retinoid metabolism and transport, organism-specific biosystem (from REACTOME)
      Retinoid metabolism and transport, organism-specific biosystemVitamin A (all-trans-retinol) must be taken up, either as carotenes from plants, or as retinyl esters from animal food. The most prominent carotenes are alpha-carotene, lycopene, lutein, beta-cryptox...
    • Scavenging of Heme from Plasma, organism-specific biosystem (from REACTOME)
      Scavenging of Heme from Plasma, organism-specific biosystemFree heme is damaging to tissues as it intercalates into biologic membranes, perturbing lipid bilayers and promoting the conversion of low-density lipoprotein to cytotoxic oxidized products. Moreover...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Statin Pathway, organism-specific biosystem (from WikiPathways)
      Statin Pathway, organism-specific biosystemStatins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in...
    • Visual phototransduction, organism-specific biosystem (from REACTOME)
      Visual phototransduction, organism-specific biosystemVisual phototransduction is the process by which photon absorption by visual pigment molecules in photoreceptor cells is converted to an electrical cellular response. The events in this process are p...
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
      amb2 Integrin signaling, organism-specific biosystem
      amb2 Integrin signaling

    Markers

    Homology

    Clone Names

    • FLJ16451, MGC88725

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    apolipoprotein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apolipoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lipoprotein particle receptor binding IC
    Inferred by Curator
    more info
    PubMed 
    lipoprotein transporter activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    aorta morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    apoptotic cell clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    beta-amyloid clearance TAS
    Traceable Author Statement
    more info
    PubMed 
    cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipoprotein transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of Wnt receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of platelet-derived growth factor receptor-beta signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of smooth muscle cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phototransduction, visible light TAS
    Traceable Author Statement
    more info
     
    positive regulation of cholesterol efflux ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of lipid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cholesterol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of phospholipase A2 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    retinoid metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    integral to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    prolow-density lipoprotein receptor-related protein 1
    Names
    prolow-density lipoprotein receptor-related protein 1
    LRP-1
    type V tgf-beta receptor
    apolipoprotein E receptor
    alpha-2-macroglobulin receptor
    TbetaR-V/LRP-1/IGFBP-3 receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016444.1 RefSeqGene

      Range
      5001..89861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002332.2NP_002323.2  prolow-density lipoprotein receptor-related protein 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AB209498, AC137834, BU502641, X13916
      Consensus CDS
      CCDS8932.1
      UniProtKB/Swiss-Prot
      Q07954
      UniProtKB/TrEMBL
      Q59FG2
      Related
      ENSP00000243077, OTTHUMP00000245726, ENST00000243077, OTTHUMT00000412772
      Conserved Domains (9) summary
      cd00054
      Location:29823014
      Blast Score: 94
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00112
      Location:35753609
      Blast Score: 136
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      COG3386
      Location:22532438
      Blast Score: 120
      COG3386; Gluconolactonase [Carbohydrate transport and metabolism]
      COG3391
      Location:39144115
      Blast Score: 124
      COG3391; Uncharacterized conserved protein [Function unknown]
      smart00135
      Location:30943136
      Blast Score: 158
      LY; Low-density lipoprotein-receptor YWTD domain
      pfam00058
      Location:40134054
      Blast Score: 161
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam12662
      Location:29622985
      Blast Score: 102
      cEGF; Complement Clr-like EGF-like
      cl00057
      Location:145187
      Blast Score: 104
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl00104
      Location:934955
      Blast Score: 87
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p10 Primary Assembly

      Range
      57522282..57607142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      54560642..54624427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018923.1 Alternate CHM1_1.0

      Range
      57356187..57441043
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

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