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ppl pumpless [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40349, updated on 4-Apr-2024

Summary

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Official Symbol
pplprovided by FlyBase
Official Full Name
pumplessprovided by FlyBase
Primary source
FLYBASE:FBgn0027945
Locus tag
Dmel_CG7758
See related
AllianceGenome:FB:FBgn0027945
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7758; Dmel\CG7758; l(3)00217; l(3)78Cb
Summary
Predicted to be involved in glycine decarboxylation via glycine cleavage system and protein lipoylation. Predicted to be part of glycine cleavage complex. Predicted to be active in mitochondrion. Is expressed in several structures, including adult heart; anterior endoderm; anterior endoderm anlage; fat body; and germ layer derivative. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human GCSH (glycine cleavage system protein H). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ppl in Genome Data Viewer
Location:
78C4-78C4; 3-47 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21280491..21281506, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21273591..21274606, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45162 Neighboring gene uncharacterized protein Neighboring gene Acetyl Coenzyme A synthase Neighboring gene uncharacterized protein Neighboring gene putzig

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Synphilin-1 alters metabolic homeostasis in a novel Drosophila obesity model. Liu J, et al. Int J Obes (Lond), 2012 Dec. PMID 22828940, Free PMC Article
  2. Suppression of food intake and growth by amino acids in Drosophila: the role of pumpless, a fat body expressed gene with homology to vertebrate glycine cleavage system. Zinke I, et al. Development, 1999 Dec. PMID 10556053
  3. Drosophila ALS regulates growth and metabolism through functional interaction with insulin-like peptides. Arquier N, et al. Cell Metab, 2008 Apr. PMID 18396139
  4. The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection. Zaidman-Rémy A, et al. Immunity, 2006 Apr. PMID 16618604
  5. Orbit, a novel microtubule-associated protein essential for mitosis in Drosophila melanogaster. Inoue YH, et al. J Cell Biol, 2000 Apr 3. PMID 10747094, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in glycine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycine decarboxylation via glycine cleavage system IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine decarboxylation via glycine cleavage system IEA
Inferred from Electronic Annotation
more info
  
involved_in protein lipoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glycine cleavage complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
pumpless
Names
CG7758-PA
ppl-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21280491..21281506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079473.4 → NP_524197.1  pumpless [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524197.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U616, Q9VP59
    Related
    FBpp0078066
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U616.1 Q9U616

Gene LinkOut

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Chemical Information
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