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    LRMP lymphoid-restricted membrane protein [ Homo sapiens ]

    Gene ID: 4033, updated on 11-May-2012
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    Summary

    Official Symbol
    LRMPprovided by HGNC
    Official Full Name
    lymphoid-restricted membrane proteinprovided by HGNC
    Primary source
    HGNC:6690
    See related
    Ensembl:ENSG00000118308; HPRD:03593; MIM:602003; Vega:OTTHUMG00000170192
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JAW1
    Summary
    The protein encode dby this gene is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. The protein is localized to the cytoplasmic face of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    12p12.1
    Sequence :
    Chromosome: 12; NC_000012.11 (25205181..25261269)
    See LRMP in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene chromosome 12 open reading frame 77 Neighboring gene uncharacterized LOC645177 Neighboring gene MLF1 interacting protein pseudogene Neighboring gene cancer susceptibility candidate 1 Neighboring gene LYR motif containing 5 Neighboring gene v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A human MAP kinase interactome. Bandyopadhyay S, et al. Nat Methods, 2010 Oct. PMID 20936779.
    2. Genome-wide association analysis identifies multiple loci related to resting heart rate. Eijgelsheim M, et al. Hum Mol Genet, 2010 Oct 1. PMID 20639392.
    3. A Large-scale genetic association study of esophageal adenocarcinoma risk. Liu CY, et al. Carcinogenesis, 2010 Jul. PMID 20453000.
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    5. New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide association analysis identifies multiple loci related to resting heart rate.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    3. Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
      Title: A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: A Large-scale genetic association study of esophageal adenocarcinoma risk.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:110213 BioGRID:113363 YWHAE    BioGRID  PubMed Two-hybrid 
    BioGRID:110213 BioGRID:113366 YWHAZ    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    vesicle fusion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    vesicle targeting TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    lymphoid-restricted membrane protein
    Names
    lymphoid-restricted membrane protein
    protein Jaw1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204126.1 → NP_001191055.1  lymphoid-restricted membrane protein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC023510, AW206014, BC144164, DB135324
      Consensus CDS
      CCDS8701.1
      UniProtKB/Swiss-Prot
      Q12912
      Related
      ENSP00000450246, OTTHUMP00000243185, ENST00000547044, OTTHUMT00000407872
      Conserved Domains (1) summary
      pfam05781
      Location:1 – 499
      Blast Score: 1854
      MRVI1; MRVI1 protein

    2. NM_001204127.1 → NP_001191056.1  lymphoid-restricted membrane protein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC023510, AK303256, AW206014, DB135324
      Consensus CDS
      CCDS8701.1
      UniProtKB/Swiss-Prot
      Q12912
      Related
      ENSP00000446496, OTTHUMP00000243183, ENST00000548766, OTTHUMT00000407869
      Conserved Domains (1) summary
      pfam05781
      Location:1 – 499
      Blast Score: 1854
      MRVI1; MRVI1 protein

    3. NM_006152.3 → NP_006143.2  lymphoid-restricted membrane protein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC023510, AW206014, BC126417, DB135324
      Consensus CDS
      CCDS8701.1
      UniProtKB/Swiss-Prot
      Q12912
      Related
      ENSP00000346442, OTTHUMP00000243184, ENST00000354454, OTTHUMT00000407870
      Conserved Domains (1) summary
      pfam05781
      Location:1 – 499
      Blast Score: 1854
      MRVI1; MRVI1 protein

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      25205181..25261269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      24975144..25031962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC023510.16 (29284..85312) None
    genomic CH471094.1 EAW96503.1
      EAW96504.1
      EAW96505.1
    genomic JA738685.1 CCF76995.1
    mRNA AI949664.1 None
    mRNA AK303103.1 BAG64212.1
    mRNA AK303256.1 BAG64339.1
    mRNA AW206014.1 None
    mRNA AW408383.1 None
    mRNA BC029391.1 AAH29391.1
    mRNA BC100277.1 None
    mRNA BC126417.1 AAI26418.1
    mRNA BC144164.1 None
    mRNA BC144165.1 None
    mRNA BC144170.1 None
    mRNA BG505192.1 None
    mRNA BM466207.1 None
    mRNA BQ220483.1 None
    mRNA BQ420905.1 None
    mRNA BU679233.1 None
    mRNA DB135324.1 None
    mRNA U10485.1 AAA21604.1
    other-genetic HQ258271.1 ADR83025.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12912.3 GenPept UniProtKB/Swiss-Prot:Q12912
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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