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akt2l v-akt murine thymoma viral oncogene homolog 2, like [ Danio rerio (zebrafish) ]

Gene ID: 403146, updated on 11-Apr-2024

Summary

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Official Symbol
akt2lprovided by ZNC
Official Full Name
v-akt murine thymoma viral oncogene homolog 2, likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040121-5
See related
AllianceGenome:ZFIN:ZDB-GENE-040121-5
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Predicted to act upstream of or within protein phosphorylation. Is expressed in digestive system; lens; pectoral fin musculature; solid lens vesicle; and yolk syncytial layer. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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Location:
chromosome: 10
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (311721..322852, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (311721..321124, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene EMSY transcriptional repressor, BRCA2 interacting Neighboring gene wu:fj39h09 Neighboring gene vasodilator stimulated phosphoprotein a Neighboring gene zgc:171929

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Developmental toxicity and apoptosis in zebrafish embryos induced by low-dose γ-ray irradiation. Zhao W, et al. Environ Sci Pollut Res Int, 2019 Feb. PMID 30539402
  2. Akt1 mediates neuronal differentiation in zebrafish via a reciprocal interaction with notch signaling. Cheng YC, et al. PLoS One, 2013. PMID 23342113, Free PMC Article
  3. FACS-assisted microarray profiling implicates novel genes and pathways in zebrafish gastrointestinal tract development. Stuckenholz C, et al. Gastroenterology, 2009 Oct. PMID 19563808, Free PMC Article
  4. Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model. Michailidou C, et al. Dis Model Mech, 2009 Jul-Aug. PMID 19470611
  5. Rapamycin reduces mortality in acute-stage paraquat-induced toxicity in zebrafish. Feng N, et al. Singapore Med J, 2019 May. PMID 30402654, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RAC-alpha serine/threonine-protein kinase; v-akt murine thymoma viral oncogene homolog 2, like
NP_997980.1
XP_021334818.1
XP_021334819.1
XP_021334820.1
XP_021334821.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212815.2 → NP_997980.1  v-akt murine thymoma viral oncogene homolog 2, like

    See identical proteins and their annotated locations for NP_997980.1

    Status: PROVISIONAL

    Source sequence(s)
    BC046892
    UniProtKB/TrEMBL
    Q802Y3
    Conserved Domains (4) summary
    cd05595
    Location:153 → 475
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    smart00220
    Location:149 → 406
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    pfam00169
    Location:6 → 106
    PH; PH domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    311721..322852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479143.1 → XP_021334818.1  RAC-alpha serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8M9QBX9
    Conserved Domains (3) summary
    smart00133
    Location:553 → 621
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cl21453
    Location:153 → 462
    PKc_like; Protein Kinases, catalytic domain

  2. XM_021479144.1 → XP_021334819.1  RAC-alpha serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8M9QBX9
    Conserved Domains (3) summary
    smart00133
    Location:553 → 621
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cl21453
    Location:153 → 462
    PKc_like; Protein Kinases, catalytic domain

  3. XM_021479145.1 → XP_021334820.1  RAC-alpha serine/threonine-protein kinase isoform X2

    UniProtKB/TrEMBL
    A0A8M9QKM2
    Conserved Domains (1) summary
    cl21453
    Location:1 → 237
    PKc_like; Protein Kinases, catalytic domain

  4. XM_021479146.1 → XP_021334821.1  RAC-alpha serine/threonine-protein kinase isoform X3

    UniProtKB/TrEMBL
    A0A8M9QGH5
    Conserved Domains (1) summary
    cl21453
    Location:1 → 184
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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