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    CSN3 COP9 complex homolog subunit 3 [ Drosophila melanogaster ]

    Gene ID: 40308, updated on 10-May-2012
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    Summary

    Official Symbol
    CSN3provided by Flybase
    Official Full Name
    COP9 complex homolog subunit 3provided by Flybase
    Primary source
    FLYBASE:FBgn0027055
    Locus tag
    Dmel_CG18332
    Gene type
    protein coding
    RNA name
    COP9 complex homolog subunit 3
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18332; CH3; Csn3; Dch3; DCH3; dCSN3; Dmel\CG18332; FBgn0027055
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    Genomic context

    Location :
    77F1-77F1
    Sequence :
    Chromosome: 3L; NT_037436.3 (20832194..20834675, complement)
    See CSN3 in Epigenomics, MapViewer

    Chromosome 3L - NT_037436.3Genomic Context describing neighboring genes Neighboring gene CG3288 gene product from transcript CG3288-RA Neighboring gene CG13255 gene product from transcript CG13255-RA Neighboring gene CG11456 gene product from transcript CG11456-RB Neighboring gene CG32432 gene product from transcript CG32432-RA Neighboring gene Seminal fluid protein 77F

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Drosophila histone locus bodies form by hierarchical recruitment of components. White AE, et al. J Cell Biol, 2011 May 16. PMID 21576393.
    3. A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint. Kondo S, et al. Sci Signal, 2011 Jan 4. PMID 21205937.
    4. Some novel intron positions in conserved Drosophila genes are caused by intron sliding or tandem duplication. Lehmann J, et al. BMC Evol Biol, 2010 May 26. PMID 20500887.
    5. Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer JL, et al. Nature, 2009 Apr 23. PMID 19363474.

    See all (22) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data revealed that MLF interacts with CSN3 in vivo and that the PCI domain of the dCSN3 protein is sufficient for this to occur, possibly functioning as a structural scaffold for assembly of the COP9 signalosome complex.
      Title: The myeloid leukemia factor interacts with COP9 signalosome subunit 3 in Drosophila melanogaster.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:65565 BioGRID:67510 C15    BioGRID  PubMed Two-hybrid 
    BioGRID:65565 BioGRID:60579 CG14071    BioGRID  PubMed Two-hybrid 
    BioGRID:65565 BioGRID:72598 CG17059    BioGRID  PubMed Two-hybrid 
    BioGRID:65565 BioGRID:57754 CG2865    BioGRID  PubMed Two-hybrid 
    BioGRID:65565 BioGRID:58854 CG8128    BioGRID  PubMed Two-hybrid 
    BioGRID:65565 BioGRID:63706 CG9173    BioGRID  PubMed Two-hybrid 
    BioGRID:65565 BioGRID:60757 CG9426    BioGRID  PubMed Two-hybrid 
    BioGRID:65565 BioGRID:61669 CSN7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:65565 BioGRID:302275 CSN8    BioGRID  PubMed Two-hybrid 
    BioGRID:65565 BioGRID:62567 Cdk4    BioGRID  PubMed Two-hybrid 
    BioGRID:65565 BioGRID:64793 Klc    BioGRID  PubMed Two-hybrid 
    BioGRID:65565 BioGRID:62960 MED8    BioGRID  PubMed Two-hybrid 
    BioGRID:65565 BioGRID:77789 Pp2A-29B    BioGRID  PubMed Two-hybrid 
    BioGRID:65565 BioGRID:65884 noi    BioGRID  PubMed Two-hybrid 
    BioGRID:65565 BioGRID:58172 p115    BioGRID  PubMed Two-hybrid 
    BioGRID:65565 BioGRID:65883 rev7    BioGRID  PubMed Two-hybrid 
    BioGRID:65565 BioGRID:58031 rux    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the CSN3 gene: The CSN3 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, A.thaliana, and rice.

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    lateral inhibition IMP
    Inferred from Mutant Phenotype
    more info
    		  
    mitotic cell cycle G2/M transition DNA damage checkpoint IGI
    Inferred from Genetic Interaction
    more info
    		  
    protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    signalosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    signalosome NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CG18332 gene product from transcript CG18332-RA
    Names
    CG18332-PA
    COP9 complex homolog subunit 3
    CSN3-PA
    drosophila COP9 signalosome homolog 3
    NP_524190.2
    • unusual splice
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.3

      Range
      20832194..20834675, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079466.2 → NP_524190.2  COP9 complex homolog subunit 3 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SYG2
      Related
      FBpp0077927, FBtr0078269
      Conserved Domains (1) summary
      cl02111
      Location:276 – 376
      Blast Score: 180
      PCI; PCI domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014296.4 AAF51652.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYG2.2 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content