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egf epidermal growth factor [ Danio rerio (zebrafish) ]

Gene ID: 403045, updated on 7-May-2016
Official Symbol
egfprovided by ZNC
Official Full Name
epidermal growth factorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070922-1
See related
Ensembl:ENSDARG00000052739 Vega:OTTDARG00000028045
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
Orthologs
Location:
chromosome: 14
Exon count:
24
Annotation release Status Assembly Chr Location
104 current GRCz10 (GCF_000002035.5) 14 NC_007125.6 (35939512..35985425, complement)
103 previous assembly Zv9 (GCF_000002035.4) 14 NC_007125.5 (37499208..37546191, complement)

Chromosome 14 - NC_007125.6Genomic Context describing neighboring genes Neighboring gene paired-like homeodomain 2 Neighboring gene ELOVL fatty acid elongase 6 Neighboring gene info leucine-rich repeat, immunoglobulin-like and transmembrane domains 3a Neighboring gene glycoprotein M6Aa

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
Wnt-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Wnt signaling pathway involved in dorsal/ventral axis specification IBA
Inferred from Biological aspect of Ancestor
more info
 
blood circulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
pro-epidermal growth factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205731.1NP_991294.1  pro-epidermal growth factor

    See identical proteins and their annotated locations for NP_991294.1

    Status: PROVISIONAL

    Source sequence(s)
    AY332224
    UniProtKB/TrEMBL
    Q6VQA2
    Related
    ENSDARP00000069126, OTTDARP00000030455, ENSDART00000074639, OTTDART00000037999
    Conserved Domains (5) summary
    PHA03099
    Location:896995
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    smart00135
    Location:571613
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00054
    Location:840875
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam14670
    Location:378413
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:288331
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz10 Primary Assembly

Genomic

  1. NC_007125.6 Reference GRCz10 Primary Assembly

    Range
    35939512..35985425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009291103.1XP_009289378.1  

    Related
    ENSDARP00000142359, OTTDARP00000049094, ENSDART00000172783, OTTDART00000062802
    Conserved Domains (7) summary
    PHA03099
    Location:9581057
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    smart00135
    Location:634676
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00054
    Location:903938
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam14670
    Location:441476
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cd05819
    Location:4777
    NHL; NHL repeat [structural motif]
    cl00057
    Location:351394
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl18310
    Location:34197
    NHL; NHL repeat unit of beta-propeller proteins
  2. XM_005157314.2XP_005157371.1  

    UniProtKB/TrEMBL
    F1QGQ2
    Related
    ENSDARP00000111809, ENSDART00000126178
    Conserved Domains (7) summary
    PHA03099
    Location:9591058
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    smart00135
    Location:634676
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00054
    Location:903938
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam14670
    Location:441476
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cd05819
    Location:4777
    NHL; NHL repeat [structural motif]
    cl00057
    Location:351394
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl18310
    Location:34197
    NHL; NHL repeat unit of beta-propeller proteins