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ARL2 ADP-ribosylation factor-like 2 [ Homo sapiens (human) ]

Gene ID: 402, updated on 7-Aug-2014
Official Symbol
ARL2provided by HGNC
Official Full Name
ADP-ribosylation factor-like 2provided by HGNC
Primary source
HGNC:693
See related
Ensembl:ENSG00000213465; HPRD:11869; MIM:601175; Vega:OTTHUMG00000165728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARFL2
Summary
This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008]
See ARL2 in Epigenomics, MapViewer
Location:
11q13
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (65014113..65022185)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64781585..64789657)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 11 open reading frame 85 Neighboring gene basic leucine zipper transcription factor, ATF-like 2 Neighboring gene ARL2-SNX15 readthrough (NMD candidate) Neighboring gene microRNA 6879 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 18 Neighboring gene sorting nexin 15

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-chaperonin tubulin folding pathway, organism-specific biosystem (from REACTOME)
    Post-chaperonin tubulin folding pathway, organism-specific biosystemAlpha and beta tubulin folding intermediates are formed through ATP-dependent interaction with TriC/CCT. In order to form a functional heterodimer, these folding intermediates undergo a series of i...
  • Protein folding, organism-specific biosystem (from REACTOME)
    Protein folding, organism-specific biosystemDue to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough ARL2-SNX15

Readthrough gene: ARL2-SNX15, Included gene: SNX15

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
GTPase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
GTP catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
centrosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of protein location in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell-substrate adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
tight junction assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
tubulin complex assembly TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
lateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
ADP-ribosylation factor-like protein 2
Names
ADP-ribosylation factor-like protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199745.1NP_001186674.1  ADP-ribosylation factor-like protein 2 isoform 2

    See proteins identical to NP_001186674.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AI631767, BC002530, BG706294, CN338497
    Consensus CDS
    CCDS55770.1
    UniProtKB/Swiss-Prot
    P36404
    Related
    ENSP00000432971, OTTHUMP00000230838, ENST00000533729, OTTHUMT00000385967
    Conserved Domains (2) summary
    cd04154
    Location:3148
    Blast Score: 739
    Arl2; Arf-like 2 (Arl2) GTPase
    COG1100
    Location:13120
    Blast Score: 205
    COG1100; GTPase SAR1 and related small G proteins [General function prediction only]
  2. NM_001667.3NP_001658.2  ADP-ribosylation factor-like protein 2 isoform 1

    See proteins identical to NP_001658.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI631767, BC002530, BG706294
    Consensus CDS
    CCDS8088.1
    UniProtKB/Swiss-Prot
    P36404
    UniProtKB/TrEMBL
    Q53YD8
    Related
    ENSP00000246747, OTTHUMP00000230835, ENST00000246747, OTTHUMT00000385963
    Conserved Domains (2) summary
    cd04154
    Location:3175
    Blast Score: 915
    Arl2; Arf-like 2 (Arl2) GTPase
    COG1100
    Location:13138
    Blast Score: 242
    COG1100; GTPase SAR1 and related small G proteins [General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    65014113..65022185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    61108599..61116672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    64665310..64673383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)